Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           19     869
NP_036462                                                              19     869
NP_001243397                                                           19     869
XP_005269721                                                           19     869
XP_006726853                                                           18    1935
XP_006723596                                                           18    1935
XP_006710111                                                           18    1935
XP_005276813                                                           17    2528
XP_005248455                                                           17    2528
NP_001790                                                              17    2528
NP_079366                                                              17    3301
XP_005257601                                                           17    3301
XP_005257599                                                           17    3301
XP_005257600                                                           17    3301
NP_056507                                                              17    4312
NP_758441                                                              17    4312
NP_055444                                                              16    5631
NP_653191                                                              16    5631
NP_001258652                                                           16    5631
NP_110420                                                              16    5631
XP_006725174                                                           16    5631
XP_006725173                                                           16    5631
XP_006725172                                                           16    5631
XP_006725171                                                           16    5631
XP_006725170                                                           16    5631
XP_006725169                                                           16    5631
XP_006725168                                                           16    5631
XP_006725167                                                           16    5631
XP_005266099                                                           16    5631
XP_006716304                                                           16    5631
XP_006716303                                                           16    5631
XP_006716302                                                           16    5631
XP_005266098                                                           16    5631
XP_005266097                                                           16    5631
XP_005266096                                                           16    5631
XP_006716301                                                           16    5631
XP_006714860                                                           16    5631
XP_006714859                                                           16    5631
XP_005268570                                                           16    5631
NP_003048                                                              16    7355
NP_694857                                                              16    7355
NP_001070650                                                           16    7355
NP_036550                                                              16    7355
NP_003260                                                              16    7355
NP_001273031                                                           16    7355
XP_005257253                                                           16    7355
XP_005257252                                                           16    7355
XP_005267162                                                           16    7355
XP_005267161                                                           16    7355
XP_006715615                                                           16    7355
XP_005267160                                                           16    7355
XP_005267159                                                           16    7355
NP_001230913                                                           15    9605
NP_068810                                                              15    9605
NP_001138610                                                           15    9605
NP_001230914                                                           15    9605
NP_001009                                                              15    9605
NP_000982                                                              15    9605
NP_689497                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           AIKRKR FV
Sbjct: 828 AIKRKRPFV 836
>NP_036462
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AIKRKRTFV 9
            AIKRKR FV
Sbjct: 1120 AIKRKRPFV 1128
>NP_001243397
          Length = 1890

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           AIKRKR FV
Sbjct: 937 AIKRKRPFV 945
>XP_005269721
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AIKRKRTFV 9
            AIKRKR FV
Sbjct: 1120 AIKRKRPFV 1128
>XP_006726853
          Length = 707

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AIKRKRTFV 9
           ++KR+RTFV
Sbjct: 221 SLKRQRTFV 229
>XP_006723596
          Length = 707

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AIKRKRTFV 9
           ++KR+RTFV
Sbjct: 221 SLKRQRTFV 229
>XP_006710111
          Length = 566

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  AIKRKRTFV 9
          ++KR+RTFV
Sbjct: 80 SLKRQRTFV 88
>XP_005276813
          Length = 289

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           AIKRKRT
Sbjct: 269 AIKRKRT 275
>XP_005248455
          Length = 289

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           AIKRKRT
Sbjct: 269 AIKRKRT 275
>NP_001790
          Length = 346

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           AIKRKRT
Sbjct: 326 AIKRKRT 332
>NP_079366
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KRKRTFV 9
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257601
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KRKRTFV 9
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257599
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KRKRTFV 9
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257600
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KRKRTFV 9
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>NP_056507
          Length = 1932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KRKRTF 8
           KRKRTF
Sbjct: 788 KRKRTF 793
>NP_758441
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IKRKRTF 8
           IK+KRTF
Sbjct: 210 IKQKRTF 216
>NP_055444
          Length = 1344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 342 AVKRGRSFI 350
>NP_653191
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AIKRKRTFV 9
          A+K+K TF+
Sbjct: 80 AVKKKFTFI 88
>NP_001258652
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           A+KRKRT
Sbjct: 649 AMKRKRT 655
>NP_110420
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           A+KRKRT
Sbjct: 819 AMKRKRT 825
>XP_006725174
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 304 AVKRGRSFI 312
>XP_006725173
          Length = 1328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_006725172
          Length = 1329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 327 AVKRGRSFI 335
>XP_006725171
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 328 AVKRGRSFI 336
>XP_006725170
          Length = 1345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 343 AVKRGRSFI 351
>XP_006725169
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_006725168
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 366 AVKRGRSFI 374
>XP_006725167
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_005266099
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 304 AVKRGRSFI 312
>XP_006716304
          Length = 1328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_006716303
          Length = 1329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 327 AVKRGRSFI 335
>XP_006716302
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 328 AVKRGRSFI 336
>XP_005266098
          Length = 1345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 343 AVKRGRSFI 351
>XP_005266097
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_005266096
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 366 AVKRGRSFI 374
>XP_006716301
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIKRKRTFV 9
           A+KR R+F+
Sbjct: 367 AVKRGRSFI 375
>XP_006714860
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           A+KRKRT
Sbjct: 852 AMKRKRT 858
>XP_006714859
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           A+KRKRT
Sbjct: 894 AMKRKRT 900
>XP_005268570
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AIKRKRT 7
           A+KRKRT
Sbjct: 894 AMKRKRT 900
>NP_003048
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 344 RKRTFI 349
>NP_694857
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 344 RKRTFI 349
>NP_001070650
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  AIKRKRTFV 9
          ++KRK+T+V
Sbjct: 39 SLKRKQTWV 47
>NP_036550
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  AIKRKRTFV 9
          ++KRK+T+V
Sbjct: 39 SLKRKQTWV 47
>NP_003260
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AIKRKRTFV 9
          +I+R RT+V
Sbjct: 43 SIRRNRTYV 51
>NP_001273031
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AIKRKRTFV 9
          +I+R RT+V
Sbjct: 80 SIRRNRTYV 88
>XP_005257253
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  AIKRKRTFV 9
          ++KRK+T+V
Sbjct: 39 SLKRKQTWV 47
>XP_005257252
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  AIKRKRTFV 9
          ++KRK+T+V
Sbjct: 39 SLKRKQTWV 47
>XP_005267162
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 152 RKRTFI 157
>XP_005267161
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 152 RKRTFI 157
>XP_006715615
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 344 RKRTFI 349
>XP_005267160
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 344 RKRTFI 349
>XP_005267159
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RKRTFV 9
           RKRTF+
Sbjct: 344 RKRTFI 349
>NP_001230913
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KRKRTF 8
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_068810
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KRKRTF 8
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_001138610
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KRKRTF 8
           KRKRT+
Sbjct: 298 KRKRTY 303
>NP_001230914
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KRKRTF 8
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_001009
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  KRKRTF 8
          K+KRTF
Sbjct: 7  KKKRTF 12
>NP_000982
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IKRKRT 7
           +KRKRT
Sbjct: 126 VKRKRT 131
>NP_689497
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AIKRKRTF 8
          A+KRK+ F
Sbjct: 68 ALKRKKRF 75
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.143    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 474,353
Number of extensions: 498
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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