Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              18    1135
XP_006717990                                                           18    1135
XP_006717989                                                           18    1135
NP_001245210                                                           18    1482
NP_000242                                                              18    1482
XP_005264389                                                           18    1482
NP_056040                                                              17    2528
XP_005251811                                                           17    2528
XP_005251810                                                           17    2528
XP_005251809                                                           17    2528
XP_005251808                                                           17    2528
XP_005251807                                                           17    2528
XP_005251805                                                           17    2528
XP_005251803                                                           17    2528
XP_006717050                                                           17    2528
XP_005251802                                                           17    2528
XP_006717049                                                           17    2528
XP_006717048                                                           17    2528
XP_006717047                                                           17    2528
XP_006717046                                                           17    2528
XP_006717045                                                           17    2528
NP_733841                                                              17    4312
NP_004671                                                              17    4312
NP_001003895                                                           17    4312
XP_006719560                                                           17    4312
XP_005269075                                                           17    4312
NP_060458                                                              17    4312
NP_001003894                                                           17    4312
NP_037365                                                              16    5631
NP_036443                                                              16    5631
XP_006717498                                                           16    5631
XP_006717497                                                           16    5631
XP_005246522                                                           16    5631
NP_001171536                                                           16    7355
NP_000379                                                              16    7355
NP_001191762                                                           16    7355
NP_001191760                                                           16    7355
NP_060545                                                              16    7355
NP_001191761                                                           16    7355
NP_008862                                                              16    7355
NP_001273164                                                           16    7355
NP_001273166                                                           16    7355
NP_001273163                                                           16    7355
NP_001273162                                                           16    7355
NP_703150                                                              16    7355
XP_005253374                                                           16    7355
XP_005253372                                                           16    7355
XP_005247894                                                           16    7355
XP_006713853                                                           16    7355
XP_005247893                                                           16    7355
XP_006713852                                                           16    7355
XP_005265322                                                           16    7355
NP_057700                                                              15    9605
NP_001229792                                                           15    9605
NP_060463                                                              15    9605
NP_060530                                                              15    9605
NP_006382                                                              15    9605
NP_001032                                                              15    9605
NP_055769                                                              15    9605
NP_001137326                                                           15    9605
NP_001121087                                                           15    9605
NP_060487                                                              15    9605
NP_004816                                                              15    9605
XP_006719905                                                           15    9605
XP_006719904                                                           15    9605
XP_005266496                                                           15    9605
XP_005266495                                                           15    9605
XP_005269994                                                           15    9605
XP_005249361                                                           15    9605
NP_066551                                                              15    9605
NP_001001722                                                           15    9605
>NP_000305
          Length = 403

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AIIKEIVNR 9
          AIIKEIV+R
Sbjct: 3  AIIKEIVSR 11
>XP_006717990
          Length = 175

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AIIKEIVNR 9
          AIIKEIV+R
Sbjct: 3  AIIKEIVSR 11
>XP_006717989
          Length = 388

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AIIKEIVNR 9
          AIIKEIV+R
Sbjct: 3  AIIKEIVSR 11
>NP_001245210
          Length = 868

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           AI+KEIVN
Sbjct: 510 AIVKEIVN 517
>NP_000242
          Length = 934

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           AI+KEIVN
Sbjct: 576 AIVKEIVN 583
>XP_005264389
          Length = 921

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           AI+KEIVN
Sbjct: 576 AIVKEIVN 583
>NP_056040
          Length = 3088

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251811
          Length = 3060

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251810
          Length = 3062

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251809
          Length = 3063

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251808
          Length = 3075

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251807
          Length = 3088

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251805
          Length = 3090

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251803
          Length = 3091

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717050
          Length = 3092

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_005251802
          Length = 3092

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717049
          Length = 3100

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717048
          Length = 3101

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717047
          Length = 3101

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717046
          Length = 3103

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>XP_006717045
          Length = 3104

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IIKEIVNR 9
           ++KE++NR
Sbjct: 348 VVKEVINR 355
>NP_733841
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKEIVN
Sbjct: 313 VIKEIVN 319
>NP_004671
          Length = 554

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKEIVN
Sbjct: 313 VIKEIVN 319
>NP_001003895
          Length = 554

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKEIVN
Sbjct: 313 VIKEIVN 319
>XP_006719560
          Length = 826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           ++IKE++NR
Sbjct: 490 SVIKEMLNR 498
>XP_005269075
          Length = 929

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           ++IKE++NR
Sbjct: 593 SVIKEMLNR 601
>NP_060458
          Length = 929

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           ++IKE++NR
Sbjct: 593 SVIKEMLNR 601
>NP_001003894
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKEIVN
Sbjct: 313 VIKEIVN 319
>NP_037365
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           IIK IVNR
Sbjct: 149 IIKYIVNR 156
>NP_036443
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           AI+KE++++
Sbjct: 303 AIVKEVIDK 311
>XP_006717498
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           AI+KE++++
Sbjct: 197 AIVKEVIDK 205
>XP_006717497
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   AIIKEIVNR 9
           AI+KE++++
Sbjct: 303 AIVKEVIDK 311
>XP_005246522
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           IIK IVNR
Sbjct: 149 IIKYIVNR 156
>NP_001171536
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 279 LIKEIVRR 286
>NP_000379
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 279 LIKEIVRR 286
>NP_001191762
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AIIKEIVNR 9
           AI+ EI+NR
Sbjct: 256 AIVIEIMNR 264
>NP_001191760
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AIIKEIVNR 9
           AI+ EI+NR
Sbjct: 367 AIVIEIMNR 375
>NP_060545
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AIIKEIVNR 9
           AI+ EI+NR
Sbjct: 367 AIVIEIMNR 375
>NP_001191761
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AIIKEIVNR 9
           AI+ EI+NR
Sbjct: 301 AIVIEIMNR 309
>NP_008862
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 37 IIKEFINK 44
>NP_001273164
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 38 IIKEFINK 45
>NP_001273166
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 76 IIKEFINK 83
>NP_001273163
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 38 IIKEFINK 45
>NP_001273162
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 61 IIKEFINK 68
>NP_703150
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 61 IIKEFINK 68
>XP_005253374
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 38 IIKEFINK 45
>XP_005253372
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IIKEIVNR 9
          IIKE +N+
Sbjct: 38 IIKEFINK 45
>XP_005247894
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 118 LIKEIVRR 125
>XP_006713853
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 279 LIKEIVRR 286
>XP_005247893
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 279 LIKEIVRR 286
>XP_006713852
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           +IKEIV R
Sbjct: 279 LIKEIVRR 286
>XP_005265322
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AIIKEIVNR 9
           AI+ EI+NR
Sbjct: 367 AIVIEIMNR 375
>NP_057700
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KEIVNR 9
           KE+VNR
Sbjct: 575 KEVVNR 580
>NP_001229792
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>NP_060463
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>NP_060530
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           I+K+I NR
Sbjct: 131 ILKDIANR 138
>NP_006382
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           I+K +VNR
Sbjct: 231 ILKTVVNR 238
>NP_001032
          Length = 1827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IIKEIVNR 9
           ++KE+V R
Sbjct: 367 VVKEVVRR 374
>NP_055769
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KEIVNR 9
          KEI+NR
Sbjct: 51 KEIINR 56
>NP_001137326
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KEIVNR 9
          KEI+NR
Sbjct: 55 KEIINR 60
>NP_001121087
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>NP_060487
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KEIVNR 9
           KEI+NR
Sbjct: 523 KEIINR 528
>NP_004816
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKE+VN
Sbjct: 314 VIKEMVN 320
>XP_006719905
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>XP_006719904
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>XP_005266496
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 109 AVVKEIIH 116
>XP_005266495
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIIKEIVN 8
           A++KEI++
Sbjct: 144 AVVKEIIH 151
>XP_005269994
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KEIVNR 9
           KEI+NR
Sbjct: 523 KEIINR 528
>XP_005249361
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   IIKEIVNR 9
           IIKE  NR
Sbjct: 221 IIKEYTNR 228
>NP_066551
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   IIKEIVNR 9
           IIKE  NR
Sbjct: 221 IIKEYTNR 228
>NP_001001722
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIKEIVN 8
           +IKE+VN
Sbjct: 314 VIKEMVN 320
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.144    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 390,562
Number of extensions: 600
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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