Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     509
NP_001276866                                                           20     509
NP_004439                                                              20     509
NP_001276865                                                           20     509
NP_001005862                                                           20     509
XP_005257197                                                           20     509
XP_006721828                                                           20     509
NP_001036064                                                           19     665
NP_005226                                                              19     665
NP_001973                                                              19     665
XP_005246434                                                           19     665
XP_005246433                                                           19     665
XP_005246432                                                           19     665
XP_006712427                                                           19     665
NP_079284                                                              16    7355
NP_061905                                                              16    7355
NP_001275537                                                           16    7355
NP_001275536                                                           16    7355
NP_002198                                                              16    7355
XP_006711452                                                           16    7355
NP_061028                                                              15    9605
NP_001138409                                                           15    9605
NP_001273358                                                           15    9605
NP_001156685                                                           15    9605
NP_000133                                                              15    9605
NP_075254                                                              15    9605
NP_079093                                                              15    9605
NP_065928                                                              15    9605
XP_005256527                                                           15    9605
XP_006720755                                                           15    9605
XP_006713936                                                           15    9605
XP_006713935                                                           15    9605
XP_006713934                                                           15    9605
XP_006713933                                                           15    9605
XP_006713932                                                           15    9605
XP_006713931                                                           15    9605
XP_005270607                                                           15    9605
>NP_005219
          Length = 1210

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 941 IDVYMIMV 948
>NP_001276866
          Length = 1055

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 949 IDVYMIMV 956
>NP_004439
          Length = 1255

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 949 IDVYMIMV 956
>NP_001276865
          Length = 1240

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 934 IDVYMIMV 941
>NP_001005862
          Length = 1225

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 919 IDVYMIMV 926
>XP_005257197
          Length = 1225

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYMIMV
Sbjct: 919 IDVYMIMV 926
>XP_006721828
          Length = 1336

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IDVYMIMV 9
            IDVYMIMV
Sbjct: 1030 IDVYMIMV 1037
>NP_001036064
          Length = 1292

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 947 IDVYMVMV 954
>NP_005226
          Length = 1308

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 947 IDVYMVMV 954
>NP_001973
          Length = 1342

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 938 IDVYMVMV 945
>XP_005246434
          Length = 1282

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 937 IDVYMVMV 944
>XP_005246433
          Length = 1298

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 937 IDVYMVMV 944
>XP_005246432
          Length = 1307

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 962 IDVYMVMV 969
>XP_006712427
          Length = 1323

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   IDVYMIMV 9
           IDVYM+MV
Sbjct: 962 IDVYMVMV 969
>NP_079284
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 580 VDVYMI 585
>NP_061905
          Length = 1074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 580 VDVYMI 585
>NP_001275537
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 603 VDVYMI 608
>NP_001275536
          Length = 1035

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 603 VDVYMI 608
>NP_002198
          Length = 1035

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IDVYMIM 8
           ID+YM++
Sbjct: 916 IDIYMLL 922
>XP_006711452
          Length = 805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 580 VDVYMI 585
>NP_061028
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AIDVYMIM 8
           AID+Y+++
Sbjct: 327 AIDIYILV 334
>NP_001138409
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVYMIMV 9
           DVY +MV
Sbjct: 688 DVYTVMV 694
>NP_001273358
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 148 LDVYMI 153
>NP_001156685
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 724 DLYMIM 729
>NP_000133
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 722 DLYMIM 727
>NP_075254
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 610 DLYMIM 615
>NP_079093
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 508 LDVYMI 513
>NP_065928
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AIDVYMI 7
           A+D+YM+
Sbjct: 512 AVDLYML 518
>XP_005256527
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AIDVYMI 7
           A+D+YM+
Sbjct: 512 AVDLYML 518
>XP_006720755
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IDVYMI 7
           +DVYMI
Sbjct: 508 LDVYMI 513
>XP_006713936
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 722 DLYMIM 727
>XP_006713935
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 723 DLYMIM 728
>XP_006713934
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 724 DLYMIM 729
>XP_006713933
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 725 DLYMIM 730
>XP_006713932
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 726 DLYMIM 731
>XP_006713931
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVYMIM 8
           D+YMIM
Sbjct: 726 DLYMIM 731
>XP_005270607
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVYMIMV 9
           DVY +MV
Sbjct: 455 DVYTVMV 461
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.152    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 319,821
Number of extensions: 264
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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