Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           18    1482
NP_000170                                                              18    1482
NP_001268422                                                           18    1482
NP_001268423                                                           18    1482
XP_005264328                                                           18    1482
NP_003874                                                              16    5631
XP_006714865                                                           16    5631
NP_689542                                                              16    5631
NP_057613                                                              16    7355
NP_005784                                                              16    7355
XP_006719897                                                           16    7355
XP_006719896                                                           16    7355
XP_006719895                                                           16    7355
XP_005266476                                                           16    7355
XP_005264851                                                           16    7355
XP_005264850                                                           16    7355
XP_005264849                                                           16    7355
XP_006712984                                                           16    7355
XP_005264847                                                           16    7355
XP_005264846                                                           16    7355
NP_004360                                                              15    9605
NP_476508                                                              15    9605
NP_476507                                                              15    9605
NP_002461                                                              15    9605
NP_683682                                                              15    9605
NP_001073922                                                           15    9605
NP_001268370                                                           15    9605
NP_110425                                                              15    9605
XP_006723202                                                           15    9605
XP_005258796                                                           15    9605
XP_006721591                                                           15    9605
XP_005246123                                                           15    9605
XP_005246122                                                           15    9605
XP_006712316                                                           15    9605
NP_055198                                                              15    9605
NP_659400                                                              15    9605
NP_076407                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AIAHSLVLV 9
            A AHSLVLV
Sbjct: 1074 ATAHSLVLV 1082
>NP_000170
          Length = 1360

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AIAHSLVLV 9
            A AHSLVLV
Sbjct: 1204 ATAHSLVLV 1212
>NP_001268422
          Length = 1058

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AIAHSLVLV 9
           A AHSLVLV
Sbjct: 902 ATAHSLVLV 910
>NP_001268423
          Length = 1058

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AIAHSLVLV 9
           A AHSLVLV
Sbjct: 902 ATAHSLVLV 910
>XP_005264328
          Length = 1261

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AIAHSLVLV 9
            A AHSLVLV
Sbjct: 1105 ATAHSLVLV 1113
>NP_003874
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+ HSLVL
Sbjct: 30 ALTHSLVL 37
>XP_006714865
          Length = 266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+ HSLVL
Sbjct: 30 ALTHSLVL 37
>NP_689542
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIAHSLVLV 9
           ++AH++VLV
Sbjct: 378 SVAHTVVLV 386
>NP_057613
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSL+L
Sbjct: 968 ALVHSLIL 975
>NP_005784
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+AH L+L
Sbjct: 30 AVAHPLIL 37
>XP_006719897
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSL+L
Sbjct: 928 ALVHSLIL 935
>XP_006719896
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSL+L
Sbjct: 785 ALVHSLIL 792
>XP_006719895
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSL+L
Sbjct: 862 ALVHSLIL 869
>XP_005266476
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSL+L
Sbjct: 928 ALVHSLIL 935
>XP_005264851
          Length = 163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+AH L+L
Sbjct: 22 AVAHPLIL 29
>XP_005264850
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+AH L+L
Sbjct: 30 AVAHPLIL 37
>XP_005264849
          Length = 186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AIAHSLVL 8
          A+AH L+L
Sbjct: 22 AVAHPLIL 29
>XP_006712984
          Length = 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+AH L+L
Sbjct: 180 AVAHPLIL 187
>XP_005264847
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+AH L+L
Sbjct: 180 AVAHPLIL 187
>XP_005264846
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+AH L+L
Sbjct: 180 AVAHPLIL 187
>NP_004360
          Length = 3177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 2561 AVGHALVL 2568
>NP_476508
          Length = 2971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 2355 AVGHALVL 2362
>NP_476507
          Length = 2570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 1954 AVGHALVL 1961
>NP_002461
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSLVL
Sbjct: 684 AMEHSLVL 691
>NP_683682
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHSLVL 8
           AHSLVL
Sbjct: 184 AHSLVL 189
>NP_001073922
          Length = 2190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AIAHSLVLV 9
            A+AH L+L+
Sbjct: 1870 AVAHPLLLL 1878
>NP_001268370
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHSLVL 8
           AHSLVL
Sbjct: 184 AHSLVL 189
>NP_110425
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHSLVL 8
           AHSLVL
Sbjct: 184 AHSLVL 189
>XP_006723202
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHSLVL 8
          AHSLVL
Sbjct: 42 AHSLVL 47
>XP_005258796
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHSLVL 8
          AHSLVL
Sbjct: 42 AHSLVL 47
>XP_006721591
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIAHSLVL 8
           A+ HSLVL
Sbjct: 684 AMEHSLVL 691
>XP_005246123
          Length = 2770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 2154 AVGHALVL 2161
>XP_005246122
          Length = 2977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 2361 AVGHALVL 2368
>XP_006712316
          Length = 3010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIAHSLVL 8
            A+ H+LVL
Sbjct: 2394 AVGHALVL 2401
>NP_055198
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHSLVL 8
          AHSLVL
Sbjct: 42 AHSLVL 47
>NP_659400
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AIAHSLVLV 9
           A+ HS VL+
Sbjct: 594 ALTHSAVLI 602
>NP_076407
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IAHSLVLV 9
           + HSL+L+
Sbjct: 279 LGHSLILI 286
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.138    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 497,294
Number of extensions: 624
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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