Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           20     509
NP_000240                                                              20     509
NP_001161089                                                           20     509
XP_005265218                                                           20     509
NP_001171953                                                           17    4312
XP_006724302                                                           17    4312
NP_037505                                                              17    4312
NP_001257292                                                           16    5631
NP_001257291                                                           16    5631
NP_005044                                                              16    5631
NP_001120867                                                           16    5631
NP_660323                                                              16    5631
XP_005246443                                                           16    5631
XP_005246440                                                           16    5631
XP_006712429                                                           16    5631
XP_005246398                                                           16    5631
XP_005246397                                                           16    5631
XP_006712392                                                           16    5631
XP_005246396                                                           16    5631
XP_006712391                                                           16    5631
XP_006712390                                                           16    5631
XP_005246395                                                           16    5631
XP_005246394                                                           16    5631
XP_005246393                                                           16    5631
NP_006419                                                              16    7355
NP_001177716                                                           16    7355
XP_005255098                                                           16    7355
XP_005255097                                                           16    7355
NP_002205                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_660350                                                              15    9605
NP_596870                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001189336                                                           15    9605
NP_001189335                                                           15    9605
NP_115886                                                              15    9605
NP_060883                                                              15    9605
XP_006717758                                                           15    9605
XP_005249809                                                           15    9605
XP_005249808                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001167453                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_001245200
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           AHVTIT KT
Sbjct: 111 AHVTITTKT 119
>NP_000240
          Length = 756

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           AHVTIT KT
Sbjct: 111 AHVTITTKT 119
>NP_001161089
          Length = 658

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AHVTITMKT 9
          AHVTIT KT
Sbjct: 13 AHVTITTKT 21
>XP_005265218
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           AHVTIT KT
Sbjct: 111 AHVTITTKT 119
>NP_001171953
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AHVTITM 7
           AH TITM
Sbjct: 181 AHTTITM 187
>XP_006724302
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AHVTITM 7
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_037505
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AHVTITM 7
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_001257292
          Length = 308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 VTITMKT 9
         VTIT+KT
Sbjct: 3 VTITLKT 9
>NP_001257291
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 VTITMKT 9
         VTIT+KT
Sbjct: 3 VTITLKT 9
>NP_005044
          Length = 363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 VTITMKT 9
         VTIT+KT
Sbjct: 3 VTITLKT 9
>NP_001120867
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>NP_660323
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246443
          Length = 506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 HVTITMKT 9
         H T+TM+T
Sbjct: 2 HCTLTMET 9
>XP_005246440
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 HVTITMKT 9
         H T+TM+T
Sbjct: 2 HCTLTMET 9
>XP_006712429
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 HVTITMKT 9
         H T+TM+T
Sbjct: 2 HCTLTMET 9
>XP_005246398
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246397
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712392
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246396
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AHVTIT 6
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712391
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AHVTIT 6
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_006712390
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AHVTIT 6
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246395
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AHVTIT 6
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246394
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AHVTIT 6
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246393
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AHVTIT 6
           AHVTIT
Sbjct: 106 AHVTIT 111
>NP_006419
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VTITMKT 9
           VT+TM+T
Sbjct: 125 VTVTMRT 131
>NP_001177716
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HVTITMK 8
           HVT+T K
Sbjct: 204 HVTLTQK 210
>XP_005255098
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VTITMKT 9
           VT+TM+T
Sbjct: 125 VTVTMRT 131
>XP_005255097
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VTITMKT 9
           VT+TM+T
Sbjct: 156 VTVTMRT 162
>NP_002205
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVTITMK 8
           +VT+TMK
Sbjct: 431 NVTVTMK 437
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2837 HITKTMK 2843
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2837 HITKTMK 2843
>NP_660350
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           AH T+T+++
Sbjct: 237 AHTTLTLES 245
>NP_596870
          Length = 5604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_001189336
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           +H+T+ M+T
Sbjct: 324 SHLTVHMRT 332
>NP_001189335
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           +H+T+ M+T
Sbjct: 430 SHLTVHMRT 438
>NP_115886
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           +H+T+ M+T
Sbjct: 366 SHLTVHMRT 374
>NP_060883
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AHVTITMKT 9
           AHV+  +KT
Sbjct: 155 AHVSANLKT 163
>XP_006717758
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AHVTITMKT 9
           AH T+T+++
Sbjct: 237 AHTTLTLES 245
>XP_005249809
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVTITMK 8
           +VT+TMK
Sbjct: 296 NVTVTMK 302
>XP_005249808
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVTITMK 8
           +VT+TMK
Sbjct: 296 NVTVTMK 302
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2884 HITKTMK 2890
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2884 HITKTMK 2890
>NP_001167453
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AHVTITMKT 9
           AHV+  +KT
Sbjct: 150 AHVSANLKT 158
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HVTITMK 8
            H+T TMK
Sbjct: 2837 HITKTMK 2843
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.117    0.316 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 422,960
Number of extensions: 672
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package