Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     229
NP_001073942                                                           17    3301
XP_005264358                                                           17    3301
NP_001269421                                                           17    4312
NP_001239049                                                           17    4312
NP_055963                                                              17    4312
NP_001239053                                                           17    4312
NP_001239051                                                           17    4312
NP_001239048                                                           17    4312
XP_005247048                                                           17    4312
XP_005247047                                                           17    4312
NP_002255                                                              16    5631
NP_001017408                                                           16    5631
NP_065132                                                              16    5631
NP_001129687                                                           16    5631
NP_476432                                                              16    5631
XP_005247496                                                           16    5631
XP_005247494                                                           16    5631
XP_006711087                                                           16    5631
XP_006711086                                                           16    5631
NP_476431                                                              16    5631
NP_001167565                                                           16    7355
NP_001167566                                                           16    7355
NP_110378                                                              16    7355
NP_001167567                                                           16    7355
NP_001167564                                                           16    7355
NP_001121600                                                           16    7355
XP_005252632                                                           16    7355
XP_005252633                                                           16    7355
XP_006717562                                                           16    7355
XP_006717561                                                           16    7355
XP_006717560                                                           16    7355
XP_005265863                                                           16    7355
NP_443131                                                              16    7355
NP_000245                                                              15    9605
NP_001539                                                              15    9605
NP_001257856                                                           15    9605
NP_001096082                                                           15    9605
NP_036300                                                              15    9605
NP_001070886                                                           15    9605
NP_061836                                                              15    9605
NP_001257859                                                           15    9605
NP_001161374                                                           15    9605
NP_001257857                                                           15    9605
NP_001257858                                                           15    9605
NP_689691                                                              15    9605
NP_653295                                                              15    9605
NP_065879                                                              15    9605
NP_387505                                                              15    9605
NP_001007247                                                           15    9605
XP_005261051                                                           15    9605
XP_005258624                                                           15    9605
XP_005258622                                                           15    9605
XP_005258616                                                           15    9605
XP_005258615                                                           15    9605
XP_006720463                                                           15    9605
XP_006711832                                                           15    9605
XP_005273200                                                           15    9605
XP_005273198                                                           15    9605
NP_001153332                                                           15    9605
NP_001153333                                                           15    9605
NP_981951                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AGVCRKAQ 8
           AGVCRKAQ
Sbjct: 692 AGVCRKAQ 699
>NP_001073942
          Length = 497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AGVCRKAQ 8
           AGVC++A+
Sbjct: 444 AGVCKQAE 451
>XP_005264358
          Length = 504

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AGVCRKAQ 8
           AGVC++A+
Sbjct: 444 AGVCKQAE 451
>NP_001269421
          Length = 230

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AGVCRKAQ 8
          AG+CR+ Q
Sbjct: 20 AGLCRRLQ 27
>NP_001239049
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 566 GLCQKAQ 572
>NP_055963
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 566 GLCQKAQ 572
>NP_001239053
          Length = 1143

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 566 GLCQKAQ 572
>NP_001239051
          Length = 1288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 531 GLCQKAQ 537
>NP_001239048
          Length = 1330

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 566 GLCQKAQ 572
>XP_005247048
          Length = 1107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 350 GLCQKAQ 356
>XP_005247047
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GVCRKAQ 8
           G+C+KAQ
Sbjct: 380 GLCQKAQ 386
>NP_002255
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AGVCRK 6
           AGVCR+
Sbjct: 295 AGVCRR 300
>NP_001017408
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AGVCRKAQS 9
          A +C KAQS
Sbjct: 78 AQLCHKAQS 86
>NP_065132
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AGVCRKAQS 9
          A +C KAQS
Sbjct: 78 AQLCHKAQS 86
>NP_001129687
          Length = 228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AGVCRKAQS 9
           +G CR+A+S
Sbjct: 159 SGSCRRARS 167
>NP_476432
          Length = 220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AGVCRKAQS 9
           +G CR+A+S
Sbjct: 151 SGSCRRARS 159
>XP_005247496
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  AGVCRK 6
          AGVCR+
Sbjct: 94 AGVCRR 99
>XP_005247494
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AGVCRK 6
           AGVCR+
Sbjct: 295 AGVCRR 300
>XP_006711087
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AGVCRKAQS 9
           +G CR+A+S
Sbjct: 168 SGSCRRARS 176
>XP_006711086
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AGVCRKAQS 9
           +G CR+A+S
Sbjct: 168 SGSCRRARS 176
>NP_476431
          Length = 228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AGVCRKAQS 9
           +G CR+A+S
Sbjct: 159 SGSCRRARS 167
>NP_001167565
          Length = 1107

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 918 GICKKA 923
>NP_001167566
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 868 GICKKA 873
>NP_110378
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 935 GICKKA 940
>NP_001167567
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 936 GICKKA 941
>NP_001167564
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 915 GICKKA 920
>NP_001121600
          Length = 1108

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 919 GICKKA 924
>XP_005252632
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 717 GICKKA 722
>XP_005252633
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 717 GICKKA 722
>XP_006717562
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 717 GICKKA 722
>XP_006717561
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 717 GICKKA 722
>XP_006717560
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GVCRKA 7
           G+C+KA
Sbjct: 717 GICKKA 722
>XP_005265863
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G CRKA+
Sbjct: 673 GSCRKAE 679
>NP_443131
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G CRKA+
Sbjct: 673 GSCRKAE 679
>NP_000245
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AGVCRKA 7
           AGV RKA
Sbjct: 122 AGVARKA 128
>NP_001539
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G+C KAQ
Sbjct: 292 GLCYKAQ 298
>NP_001257856
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G+C KAQ
Sbjct: 292 GLCYKAQ 298
>NP_001096082
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   AGVCRKA 7
           +GVC KA
Sbjct: 98  SGVCMKA 104
>NP_036300
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   CRKAQ 8
           CRKAQ
Sbjct: 176 CRKAQ 180
>NP_001070886
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          AG+C KA
Sbjct: 17 AGLCSKA 23
>NP_061836
          Length = 2320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          AG CR+A
Sbjct: 28 AGPCRRA 34
>NP_001257859
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G+C KAQ
Sbjct: 261 GLCYKAQ 267
>NP_001161374
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          +GVC KA
Sbjct: 44 SGVCMKA 50
>NP_001257857
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G+C KAQ
Sbjct: 261 GLCYKAQ 267
>NP_001257858
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVCRKAQ 8
           G+C KAQ
Sbjct: 261 GLCYKAQ 267
>NP_689691
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 412 VCRKAFS 418
>NP_653295
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 306 VCRKAFS 312
>NP_065879
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 565 VCRKAFS 571
>NP_387505
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          AG CR+A
Sbjct: 28 AGPCRRA 34
>NP_001007247
          Length = 120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          AG CR+A
Sbjct: 28 AGPCRRA 34
>XP_005261051
          Length = 2242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          AG CR+A
Sbjct: 28 AGPCRRA 34
>XP_005258624
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 103 VCRKAFS 109
>XP_005258622
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 362 VCRKAFS 368
>XP_005258616
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 369 VCRKAFS 375
>XP_005258615
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 413 VCRKAFS 419
>XP_006720463
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  AGVCRKA 7
          +GVC KA
Sbjct: 44 SGVCMKA 50
>XP_006711832
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AGVCRKA 7
           AGV RKA
Sbjct: 122 AGVARKA 128
>XP_005273200
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AGVCRKA 7
           AGV RKA
Sbjct: 122 AGVARKA 128
>XP_005273198
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AGVCRKA 7
           AGV RKA
Sbjct: 121 AGVARKA 127
>NP_001153332
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 412 VCRKAFS 418
>NP_001153333
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VCRKAQS 9
           VCRKA S
Sbjct: 412 VCRKAFS 418
>NP_981951
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AGVCRKAQS 9
           AG+C K  +
Sbjct: 251 AGICHKVST 259
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.122    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 577,593
Number of extensions: 476
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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