Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              18    1135
NP_001166028                                                           17    3301
NP_005886                                                              17    3301
XP_006719801                                                           17    3301
XP_006719800                                                           17    3301
XP_006719799                                                           17    3301
XP_005266219                                                           17    3301
NP_001007026                                                           16    7355
NP_004862                                                              16    7355
NP_001007025                                                           16    7355
NP_997646                                                              16    7355
XP_005258129                                                           16    7355
XP_005258128                                                           16    7355
XP_005258127                                                           16    7355
XP_005263918                                                           16    7355
XP_005263917                                                           16    7355
XP_006712266                                                           16    7355
XP_006712265                                                           16    7355
XP_005263913                                                           16    7355
NP_000436                                                              15    9605
NP_958780                                                              15    9605
NP_958781                                                              15    9605
NP_958785                                                              15    9605
NP_958783                                                              15    9605
NP_958786                                                              15    9605
NP_001258463                                                           15    9605
NP_001380                                                              15    9605
NP_958782                                                              15    9605
NP_004543                                                              15    9605
NP_958784                                                              15    9605
NP_001171908                                                           15    9605
NP_003738                                                              15    9605
NP_443179                                                              15    9605
NP_001034663                                                           15    9605
XP_006724038                                                           15    9605
XP_005266703                                                           15    9605
XP_005251041                                                           15    9605
XP_005251040                                                           15    9605
XP_006716653                                                           15    9605
XP_006716652                                                           15    9605
XP_005251039                                                           15    9605
XP_005251038                                                           15    9605
XP_005251036                                                           15    9605
XP_005251037                                                           15    9605
XP_005251035                                                           15    9605
XP_006716651                                                           15    9605
XP_005251034                                                           15    9605
XP_005251033                                                           15    9605
XP_006716326                                                           15    9605
XP_006710690                                                           15    9605
>NP_003290
          Length = 803

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AGSIRKEAE 9
           AGS RKEAE
Sbjct: 542 AGSSRKEAE 550
>NP_001166028
          Length = 1134

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>NP_005886
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>XP_006719801
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>XP_006719800
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>XP_006719799
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>XP_005266219
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSIRKEA 8
           GS+RKEA
Sbjct: 114 GSVRKEA 120
>NP_001007026
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSIRKEAE 9
           GS+RK+ E
Sbjct: 138 GSVRKDIE 145
>NP_004862
          Length = 250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSIRKEAE 9
           GS+RK+ E
Sbjct: 140 GSVRKDIE 147
>NP_001007025
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSIRKEAE 9
          GS+RK+ E
Sbjct: 75 GSVRKDIE 82
>NP_997646
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 323 GSLREEAQ 330
>XP_005258129
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSIRKEAE 9
          GS+RK+ E
Sbjct: 75 GSVRKDIE 82
>XP_005258128
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSIRKEAE 9
           GS+RK+ E
Sbjct: 188 GSVRKDIE 195
>XP_005258127
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSIRKEAE 9
           GS+RK+ E
Sbjct: 190 GSVRKDIE 197
>XP_005263918
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 159 GSLREEAQ 166
>XP_005263917
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 159 GSLREEAQ 166
>XP_006712266
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 271 GSLREEAQ 278
>XP_006712265
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 322 GSLREEAQ 329
>XP_005263913
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+R+EA+
Sbjct: 376 GSLREEAQ 383
>NP_000436
          Length = 4574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2162 AEKLRKEAE 2170
>NP_958780
          Length = 4533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2121 AEKLRKEAE 2129
>NP_958781
          Length = 4525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2113 AEKLRKEAE 2121
>NP_958785
          Length = 4551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2139 AEKLRKEAE 2147
>NP_958783
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2103 AEKLRKEAE 2111
>NP_958786
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2135 AEKLRKEAE 2143
>NP_001258463
          Length = 1994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AGSIRKEAE 9
            AGS+ KE++
Sbjct: 1776 AGSVDKESD 1784
>NP_001380
          Length = 2012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AGSIRKEAE 9
            AGS+ KE++
Sbjct: 1776 AGSVDKESD 1784
>NP_958782
          Length = 4684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2272 AEKLRKEAE 2280
>NP_004543
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AGSIRKEAE 9
          AG+IRK+ +
Sbjct: 76 AGTIRKQRD 84
>NP_958784
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2135 AEKLRKEAE 2143
>NP_001171908
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AGSIRKEAE 9
          AG+IRK+ +
Sbjct: 76 AGTIRKQRD 84
>NP_003738
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            AG+ RKE E
Sbjct: 1015 AGTERKEGE 1023
>NP_443179
          Length = 2170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    GSIRKEAE 9
            GS+++EAE
Sbjct: 1473 GSMKQEAE 1480
>NP_001034663
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GSIRKE 7
           GS+RKE
Sbjct: 602 GSVRKE 607
>XP_006724038
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AGSIRKEAE 9
            AGS+ KE++
Sbjct: 1671 AGSVDKESD 1679
>XP_005266703
          Length = 1501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GSIRKEAE 9
           GS+++EAE
Sbjct: 804 GSMKQEAE 811
>XP_005251041
          Length = 4520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2108 AEKLRKEAE 2116
>XP_005251040
          Length = 4524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2112 AEKLRKEAE 2120
>XP_006716653
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2117 AEKLRKEAE 2125
>XP_006716652
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2117 AEKLRKEAE 2125
>XP_005251039
          Length = 4530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2118 AEKLRKEAE 2126
>XP_005251038
          Length = 4538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2126 AEKLRKEAE 2134
>XP_005251036
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2140 AEKLRKEAE 2148
>XP_005251037
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2140 AEKLRKEAE 2148
>XP_005251035
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2144 AEKLRKEAE 2152
>XP_006716651
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2167 AEKLRKEAE 2175
>XP_005251034
          Length = 4685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2273 AEKLRKEAE 2281
>XP_005251033
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            A  +RKEAE
Sbjct: 2277 AEKLRKEAE 2285
>XP_006716326
          Length = 1316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AGSIRKEAE 9
            AG+ RKE E
Sbjct: 1015 AGTERKEGE 1023
>XP_006710690
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GSIRKE 7
           GS+RKE
Sbjct: 602 GSVRKE 607
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.116    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,147
Number of extensions: 1056
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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