Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_006222                                                              18    1482
NP_001070254                                                           18    1482
XP_006718388                                                           18    1482
XP_006718387                                                           18    1482
XP_006718386                                                           18    1482
NP_004501                                                              17    3301
NP_004500                                                              17    3301
NP_536349                                                              17    3301
NP_056162                                                              17    3301
NP_001171944                                                           17    3301
XP_006712552                                                           17    3301
XP_006712551                                                           17    3301
XP_006712550                                                           17    3301
XP_006712549                                                           17    3301
XP_005246582                                                           17    3301
NP_001004106                                                           17    4312
NP_001004105                                                           17    4312
NP_002073                                                              17    4312
NP_689979                                                              17    4312
XP_006714923                                                           17    4312
XP_006714922                                                           17    4312
XP_006714921                                                           17    4312
NP_006599                                                              16    7355
XP_006710360                                                           16    7355
XP_005270444                                                           16    7355
XP_006710359                                                           16    7355
XP_005270442                                                           16    7355
XP_005270441                                                           16    7355
XP_005270440                                                           16    7355
NP_060897                                                              15    9605
NP_775822                                                              15    9605
NP_510880                                                              15    9605
NP_976063                                                              15    9605
XP_006725260                                                           15    9605
XP_005255432                                                           15    9605
XP_006717062                                                           15    9605
XP_006717061                                                           15    9605
XP_005251851                                                           15    9605
XP_005251850                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AFKRLGASV 9
            AFKRLGAS+
Sbjct: 1072 AFKRLGASL 1080
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AFKRLGASV 9
            AFKRLGAS+
Sbjct: 1072 AFKRLGASL 1080
>NP_006222
          Length = 2286

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    FKRLGASV 9
            FKRLG+SV
Sbjct: 1856 FKRLGSSV 1863
>NP_001070254
          Length = 1735

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AFKRLGASV 9
           AF+RLG+SV
Sbjct: 114 AFERLGSSV 122
>XP_006718388
          Length = 1331

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AFKRLGASV 9
           AF+RLG+SV
Sbjct: 177 AFERLGSSV 185
>XP_006718387
          Length = 1798

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AFKRLGASV 9
           AF+RLG+SV
Sbjct: 177 AFERLGSSV 185
>XP_006718386
          Length = 1822

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AFKRLGASV 9
           AF+RLG+SV
Sbjct: 177 AFERLGSSV 185
>NP_004501
          Length = 549

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 102 SFKRVGAS 109
>NP_004500
          Length = 689

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 102 SFKRVGAS 109
>NP_536349
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 102 SFKRVGAS 109
>NP_056162
          Length = 1052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKR GASV
Sbjct: 715 FKRRGASV 722
>NP_001171944
          Length = 555

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 108 SFKRVGAS 115
>XP_006712552
          Length = 648

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 108 SFKRVGAS 115
>XP_006712551
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 108 SFKRVGAS 115
>XP_006712550
          Length = 695

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 108 SFKRVGAS 115
>XP_006712549
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 102 SFKRVGAS 109
>XP_005246582
          Length = 719

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AFKRLGAS 8
           +FKR+GAS
Sbjct: 108 SFKRVGAS 115
>NP_001004106
          Length = 576

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 453 FKRLGAGM 460
>NP_001004105
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 453 FKRLGAGM 460
>NP_002073
          Length = 589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 453 FKRLGAGM 460
>NP_689979
          Length = 113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AFKRLGA 7
          AF+RLGA
Sbjct: 7  AFRRLGA 13
>XP_006714923
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 188 FKRLGAGM 195
>XP_006714922
          Length = 557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 421 FKRLGAGM 428
>XP_006714921
          Length = 559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKRLGASV 9
           FKRLGA +
Sbjct: 423 FKRLGAGM 430
>NP_006599
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 263 AFRRLGNGV 271
>XP_006710360
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 263 AFRRLGNGV 271
>XP_005270444
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 263 AFRRLGNGV 271
>XP_006710359
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 221 AFRRLGNGV 229
>XP_005270442
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 234 AFRRLGNGV 242
>XP_005270441
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 263 AFRRLGNGV 271
>XP_005270440
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           AF+RLG  V
Sbjct: 263 AFRRLGNGV 271
>NP_060897
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AFKRLGAS 8
          A K+LGAS
Sbjct: 20 AVKKLGAS 27
>NP_775822
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           A  RLGASV
Sbjct: 139 AQNRLGASV 147
>NP_510880
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    AFKRLG 6
            AFKR+G
Sbjct: 1925 AFKRIG 1930
>NP_976063
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    AFKRLG 6
            AFKR+G
Sbjct: 1925 AFKRIG 1930
>XP_006725260
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AFKRLGAS 8
          A K+LGAS
Sbjct: 20 AVKKLGAS 27
>XP_005255432
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AFKRLGAS 8
          A K+LGAS
Sbjct: 20 AVKKLGAS 27
>XP_006717062
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AFKRLGASV 9
          A  RLGASV
Sbjct: 81 AQNRLGASV 89
>XP_006717061
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           A  RLGASV
Sbjct: 139 AQNRLGASV 147
>XP_005251851
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           A  RLGASV
Sbjct: 139 AQNRLGASV 147
>XP_005251850
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AFKRLGASV 9
           A  RLGASV
Sbjct: 139 AQNRLGASV 147
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.136    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,763
Number of extensions: 534
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package