Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              21     175
NP_001087241                                                           21     175
XP_006714101                                                           21     175
XP_005265799                                                           21     175
XP_005265798                                                           21     175
XP_005265797                                                           21     175
NP_001138462                                                           18    1482
NP_001670                                                              17    3301
NP_000149                                                              17    4312
NP_085153                                                              17    4312
XP_005246937                                                           17    4312
XP_005246936                                                           17    4312
XP_005246935                                                           17    4312
XP_006712846                                                           17    4312
NP_005517                                                              16    5631
NP_001165276                                                           16    5631
NP_004854                                                              16    5631
NP_004497                                                              16    5631
NP_000883                                                              16    5631
NP_001230023                                                           16    5631
XP_005272374                                                           16    5631
XP_005272373                                                           16    5631
XP_005272372                                                           16    5631
XP_006714276                                                           16    5631
XP_005263044                                                           16    5631
NP_001129036                                                           16    5631
NP_000528                                                              16    7355
NP_004848                                                              16    7355
NP_001161328                                                           16    7355
NP_060653                                                              16    7355
NP_006148                                                              16    7355
NP_963845                                                              16    7355
NP_001275643                                                           16    7355
NP_001275642                                                           16    7355
NP_001265577                                                           16    7355
NP_001138482                                                           16    7355
NP_073606                                                              16    7355
NP_001265576                                                           16    7355
NP_001036039                                                           16    7355
NP_005332                                                              16    7355
XP_005255025                                                           16    7355
XP_005253633                                                           16    7355
XP_005253632                                                           16    7355
XP_006719537                                                           16    7355
XP_006719536                                                           16    7355
XP_005253630                                                           16    7355
XP_005253629                                                           16    7355
XP_006710655                                                           16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_001128303                                                           15    9605
NP_150601                                                              15    9605
NP_001128304                                                           15    9605
NP_001245300                                                           15    9605
NP_001095                                                              15    9605
NP_071351                                                              15    9605
NP_859066                                                              15    9605
NP_006150                                                              15    9605
NP_958928                                                              15    9605
NP_060158                                                              15    9605
NP_001138582                                                           15    9605
NP_001138581                                                           15    9605
NP_001138580                                                           15    9605
NP_001138579                                                           15    9605
NP_009184                                                              15    9605
XP_005256694                                                           15    9605
XP_005268962                                                           15    9605
XP_005252119                                                           15    9605
XP_006717212                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
XP_006711262                                                           15    9605
XP_005245003                                                           15    9605
>NP_000213
          Length = 976

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 482 AFKHNGTVE 490
>NP_001087241
          Length = 972

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 482 AFKHNGTVE 490
>XP_006714101
          Length = 526

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 483 AFKHNGTVE 491
>XP_005265799
          Length = 973

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 483 AFKHNGTVE 491
>XP_005265798
          Length = 976

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 483 AFKHNGTVE 491
>XP_005265797
          Length = 977

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AFKHNGMVE 9
           AFKHNG VE
Sbjct: 483 AFKHNGTVE 491
>NP_001138462
          Length = 1742

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FKHNGMVE 9
            FKH G+VE
Sbjct: 1354 FKHEGIVE 1361
>NP_001670
          Length = 279

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FKHNGMVE 9
           + HNGM++
Sbjct: 204 YPHNGMID 211
>NP_000149
          Length = 702

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AFKHNG 6
           AF+HNG
Sbjct: 673 AFEHNG 678
>NP_085153
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           F HNGM
Sbjct: 280 FSHNGM 285
>XP_005246937
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           F HNGM
Sbjct: 162 FSHNGM 167
>XP_005246936
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           F HNGM
Sbjct: 205 FSHNGM 210
>XP_005246935
          Length = 381

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           F HNGM
Sbjct: 280 FSHNGM 285
>XP_006712846
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           F HNGM
Sbjct: 280 FSHNGM 285
>NP_005517
          Length = 529

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 61 FKHNNM 66
>NP_001165276
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   KHNGM 7
           KHNGM
Sbjct: 478 KHNGM 482
>NP_004854
          Length = 562

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FKHNGM 7
           FKHN M
Sbjct: 280 FKHNNM 285
>NP_004497
          Length = 536

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 53 FKHNNM 58
>NP_000883
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   KHNGM 7
           KHNGM
Sbjct: 585 KHNGM 589
>NP_001230023
          Length = 230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 53 FKHNNM 58
>XP_005272374
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 61 FKHNNM 66
>XP_005272373
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 61 FKHNNM 66
>XP_005272372
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 61 FKHNNM 66
>XP_006714276
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   KHNGM 7
           KHNGM
Sbjct: 547 KHNGM 551
>XP_005263044
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   KHNGM 7
           KHNGM
Sbjct: 577 KHNGM 581
>NP_001129036
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  FKHNGM 7
          FKHN M
Sbjct: 53 FKHNNM 58
>NP_000528
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   AFKHNG 6
           ++KHNG
Sbjct: 137 SYKHNG 142
>NP_004848
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FKHNGMVE 9
           FK NG+ E
Sbjct: 317 FKENGITE 324
>NP_001161328
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 387 KHNGSVK 393
>NP_060653
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 386 KHNGSVK 392
>NP_006148
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG V
Sbjct: 641 KHNGQV 646
>NP_963845
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG V
Sbjct: 594 KHNGQV 599
>NP_001275643
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG V
Sbjct: 584 KHNGQV 589
>NP_001275642
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG V
Sbjct: 669 KHNGQV 674
>NP_001265577
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AFKH G
Sbjct: 427 AFKHRG 432
>NP_001138482
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  FKHNGMVE 9
          F H GM+E
Sbjct: 75 FLHKGMLE 82
>NP_073606
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AF HNG
Sbjct: 251 AFPHNG 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KHNGMVE 9
          +H+G+VE
Sbjct: 90 RHHGLVE 96
>NP_001265576
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AFKH G
Sbjct: 427 AFKHRG 432
>NP_001036039
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AF HNG
Sbjct: 251 AFPHNG 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KHNGMVE 9
          +H+G+VE
Sbjct: 90 RHHGLVE 96
>NP_005332
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AFKH G
Sbjct: 427 AFKHRG 432
>XP_005255025
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   AFKHNG 6
           AF HNG
Sbjct: 250 AFPHNG 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KHNGMVE 9
          +H+G+VE
Sbjct: 90 RHHGLVE 96
>XP_005253633
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 386 KHNGSVK 392
>XP_005253632
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 386 KHNGSVK 392
>XP_006719537
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 387 KHNGSVK 393
>XP_006719536
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 387 KHNGSVK 393
>XP_005253630
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 387 KHNGSVK 393
>XP_005253629
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           KHNG V+
Sbjct: 387 KHNGSVK 393
>XP_006710655
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  AFKHNG 6
          AFKH G
Sbjct: 85 AFKHRG 90
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>NP_150601
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG V
Sbjct: 224 KHNGWV 229
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>NP_001245300
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           K NGM+E
Sbjct: 818 KQNGMME 824
>NP_001095
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KHNGMVE 9
           K NGM+E
Sbjct: 775 KQNGMME 781
>NP_071351
          Length = 2752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  AFKHNGM 7
          AF++NG+
Sbjct: 24 AFRYNGL 30
>NP_859066
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KHNGMVE 9
           +H+G+VE
Sbjct: 99  RHHGLVE 105
>NP_006150
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 647 KHNGQI 652
>NP_958928
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   FKHNGMVE 9
           +KH GM +
Sbjct: 144 YKHQGMFQ 151
>NP_060158
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   FKHNGMVE 9
           F HNG  E
Sbjct: 336 FSHNGQHE 343
>NP_001138582
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 670 KHNGQI 675
>NP_001138581
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 646 KHNGQI 651
>NP_001138580
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 647 KHNGQI 652
>NP_001138579
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 697 KHNGQI 702
>NP_009184
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  AFKHNG 6
          AF HNG
Sbjct: 40 AFYHNG 45
>XP_005256694
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   FKHNGMVE 9
           +KH GM +
Sbjct: 144 YKHQGMFQ 151
>XP_005268962
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   KHNGMV 8
           KHNG +
Sbjct: 647 KHNGQI 652
>XP_005252119
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   FKHNGMVE 9
           F HNG  E
Sbjct: 259 FSHNGQHE 266
>XP_006717212
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   FKHNGMVE 9
           F HNG  E
Sbjct: 335 FSHNGQHE 342
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   FKHNGMV 8
           F HNG +
Sbjct: 617 FSHNGRI 623
>XP_006711262
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KHNGMVE 9
          +H+G+VE
Sbjct: 90 RHHGLVE 96
>XP_005245003
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KHNGMVE 9
           +H+G+VE
Sbjct: 99  RHHGLVE 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 663,344
Number of extensions: 953
Number of successful extensions: 76
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package