Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           18    1482
NP_001138386                                                           18    1482
NP_001138387                                                           18    1482
NP_000132                                                              18    1482
NP_075259                                                              18    1482
NP_001138391                                                           18    1482
NP_001138385                                                           18    1482
NP_075418                                                              18    1482
XP_006717776                                                           18    1482
XP_006717774                                                           18    1482
XP_006717773                                                           18    1482
XP_006717772                                                           18    1482
XP_006717771                                                           18    1482
NP_055884                                                              17    4312
NP_071926                                                              17    4312
NP_001258549                                                           17    4312
NP_001399                                                              17    4312
XP_005255914                                                           17    4312
XP_005255913                                                           17    4312
XP_005255912                                                           17    4312
XP_006721234                                                           17    4312
XP_005268557                                                           17    4312
XP_006714856                                                           17    4312
XP_005268556                                                           17    4312
XP_006714855                                                           17    4312
XP_006714854                                                           17    4312
XP_005268555                                                           17    4312
XP_005268554                                                           17    4312
XP_006710468                                                           17    4312
XP_005270637                                                           17    4312
NP_061751                                                              16    5631
NP_115782                                                              16    5631
NP_006531                                                              16    7355
NP_001167558                                                           16    7355
NP_858045                                                              16    7355
NP_006525                                                              16    7355
NP_001167559                                                           16    7355
NP_001177925                                                           16    7355
NP_006400                                                              16    7355
NP_055486                                                              16    7355
NP_114088                                                              16    7355
NP_061721                                                              16    7355
NP_671766                                                              16    7355
NP_671756                                                              16    7355
NP_001265441                                                           16    7355
NP_001265440                                                           16    7355
NP_004635                                                              16    7355
NP_003734                                                              16    7355
NP_065810                                                              16    7355
XP_006720769                                                           16    7355
XP_006720768                                                           16    7355
XP_006720767                                                           16    7355
XP_006720684                                                           16    7355
XP_005251190                                                           16    7355
XP_005251188                                                           16    7355
XP_005251189                                                           16    7355
XP_005251187                                                           16    7355
XP_005251186                                                           16    7355
XP_005251185                                                           16    7355
XP_005249622                                                           16    7355
XP_005249621                                                           16    7355
XP_006712189                                                           16    7355
XP_005264685                                                           16    7355
XP_005264684                                                           16    7355
XP_005264683                                                           16    7355
XP_005264682                                                           16    7355
NP_001153221                                                           15    9605
NP_619636                                                              15    9605
NP_055061                                                              15    9605
NP_001431                                                              15    9605
NP_060813                                                              15    9605
XP_006724446                                                           15    9605
XP_006716365                                                           15    9605
XP_006714720                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 140 AEDFVSENS 148
>NP_001138386
          Length = 709

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 140 AEDFVSENS 148
>NP_001138387
          Length = 707

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AEVFVSENS 9
          AE FVSENS
Sbjct: 51 AEDFVSENS 59
>NP_000132
          Length = 821

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 140 AEDFVSENS 148
>NP_075259
          Length = 822

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 140 AEDFVSENS 148
>NP_001138391
          Length = 680

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AEVFVSENS 9
          AE FVSENS
Sbjct: 51 AEDFVSENS 59
>NP_001138385
          Length = 769

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 140 AEDFVSENS 148
>NP_075418
          Length = 732

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AEVFVSENS 9
          AE FVSENS
Sbjct: 51 AEDFVSENS 59
>XP_006717776
          Length = 806

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 159 AEDFVSENS 167
>XP_006717774
          Length = 752

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AEVFVSENS 9
          AE FVSENS
Sbjct: 70 AEDFVSENS 78
>XP_006717773
          Length = 807

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 159 AEDFVSENS 167
>XP_006717772
          Length = 838

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 159 AEDFVSENS 167
>XP_006717771
          Length = 839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           AE FVSENS
Sbjct: 159 AEDFVSENS 167
>NP_055884
          Length = 1284

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 302 EVFVDENT 309
>NP_071926
          Length = 1544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 716 EMFASENS 723
>NP_001258549
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 242 EVFVDENT 249
>NP_001399
          Length = 2923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           +VFV ENS
Sbjct: 927 DVFVEENS 934
>XP_005255914
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 185 EVFVDENT 192
>XP_005255913
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 242 EVFVDENT 249
>XP_005255912
          Length = 1286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 304 EVFVDENT 311
>XP_006721234
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 317 EVFVDENT 324
>XP_005268557
          Length = 934

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 716 EMFASENS 723
>XP_006714856
          Length = 1346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 518 EMFASENS 525
>XP_005268556
          Length = 1466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 638 EMFASENS 645
>XP_006714855
          Length = 1473

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 716 EMFASENS 723
>XP_006714854
          Length = 1486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 658 EMFASENS 665
>XP_005268555
          Length = 1524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 716 EMFASENS 723
>XP_005268554
          Length = 1531

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           E+F SENS
Sbjct: 716 EMFASENS 723
>XP_006710468
          Length = 2916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           +VFV ENS
Sbjct: 927 DVFVEENS 934
>XP_005270637
          Length = 2921

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           +VFV ENS
Sbjct: 927 DVFVEENS 934
>NP_061751
          Length = 938

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 461 EVFVPENN 468
>NP_115782
          Length = 871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVFV EN+
Sbjct: 461 EVFVPENN 468
>NP_006531
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>NP_001167558
          Length = 1423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 135 VFVSEN 140
>NP_858045
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 135 VFVSEN 140
>NP_006525
          Length = 1420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 135 VFVSEN 140
>NP_001167559
          Length = 1415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 135 VFVSEN 140
>NP_001177925
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVSENS 9
           FVSENS
Sbjct: 240 FVSENS 245
>NP_006400
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVSENS 9
           FVSENS
Sbjct: 254 FVSENS 259
>NP_055486
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVF SEN+
Sbjct: 173 EVFSSENT 180
>NP_114088
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EVFVSENS 9
           E+FV+EN+
Sbjct: 451 ELFVAENN 458
>NP_061721
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EVFVSENS 9
           E+FV+EN+
Sbjct: 451 ELFVAENN 458
>NP_671766
          Length = 1440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>NP_671756
          Length = 1399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>NP_001265441
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 992 APVFMSEN 999
>NP_001265440
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 941 APVFMSEN 948
>NP_004635
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 973 APVFMSEN 980
>NP_003734
          Length = 1441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>NP_065810
          Length = 4700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AEVFVSENS 9
            A+VF +EN+
Sbjct: 1605 AQVFATENA 1613
>XP_006720769
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 929 APVFMSEN 936
>XP_006720768
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 929 APVFMSEN 936
>XP_006720767
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A VF+SEN
Sbjct: 943 APVFMSEN 950
>XP_006720684
          Length = 4713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AEVFVSENS 9
            A+VF +EN+
Sbjct: 1618 AQVFATENA 1626
>XP_005251190
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005251188
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005251189
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005251187
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005251186
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005251185
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 137 VFVSEN 142
>XP_005249622
          Length = 1021

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVF SEN+
Sbjct: 173 EVFSSENT 180
>XP_005249621
          Length = 1058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EVFVSENS 9
           EVF SEN+
Sbjct: 148 EVFSSENT 155
>XP_006712189
          Length = 1394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>XP_005264685
          Length = 1399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>XP_005264684
          Length = 1399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>XP_005264683
          Length = 1440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>XP_005264682
          Length = 1441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VFVSEN 8
           VFVSEN
Sbjct: 134 VFVSEN 139
>NP_001153221
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           AEV+ SEN
Sbjct: 345 AEVYGSEN 352
>NP_619636
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           A+ FVSEN
Sbjct: 123 AKKFVSEN 130
>NP_055061
          Length = 3014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EVFVSENS 9
            E+FV EN+
Sbjct: 1005 ELFVEENN 1012
>NP_001431
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           A V+V+EN+
Sbjct: 224 ANVYVTENA 232
>NP_060813
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           AEV+ SEN
Sbjct: 345 AEVYGSEN 352
>XP_006724446
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EVFVSENS 9
            E+FV EN+
Sbjct: 1005 ELFVEENN 1012
>XP_006716365
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AEVFVSENS 9
           A V+V+EN+
Sbjct: 224 ANVYVTENA 232
>XP_006714720
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEVFVSEN 8
           AEV+ SEN
Sbjct: 158 AEVYGSEN 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.112    0.261 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 415,542
Number of extensions: 787
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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