Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     869
NP_444254                                                              19     869
NP_444253                                                              19     869
NP_444255                                                              19     869
XP_005247551                                                           19     869
XP_005247550                                                           19     869
XP_006713712                                                           19     869
XP_005247549                                                           19     869
NP_002462                                                              17    4312
NP_001269480                                                           17    4312
NP_001269479                                                           17    4312
NP_055777                                                              17    4312
NP_001269483                                                           17    4312
NP_001269481                                                           17    4312
NP_848526                                                              17    4312
NP_852108                                                              17    4312
XP_006723614                                                           17    4312
XP_006723613                                                           17    4312
XP_005267752                                                           17    4312
XP_006720215                                                           17    4312
XP_006720214                                                           17    4312
XP_005267751                                                           17    4312
NP_038203                                                              16    7355
NP_002152                                                              16    7355
NP_898885                                                              16    7355
XP_005260134                                                           16    7355
XP_005260133                                                           16    7355
NP_077011                                                              16    7355
NP_114479                                                              15    9605

>NP_444256
          Length = 1794

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AETLNAKTV 9
           AETLNAK V
Sbjct: 931 AETLNAKAV 939



>NP_444254
          Length = 1845

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AETLNAKTV 9
           AETLNAK V
Sbjct: 931 AETLNAKAV 939



>NP_444253
          Length = 1914

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AETLNAKTV 9
            AETLNAK V
Sbjct: 1000 AETLNAKAV 1008



>NP_444255
          Length = 1863

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AETLNAKTV 9
            AETLNAK V
Sbjct: 1000 AETLNAKAV 1008



>XP_005247551
          Length = 1855

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AETLNAKTV 9
           AETLNAK V
Sbjct: 941 AETLNAKAV 949



>XP_005247550
          Length = 1856

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AETLNAKTV 9
            AETLNAK V
Sbjct: 1010 AETLNAKAV 1018



>XP_006713712
          Length = 1923

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AETLNAKTV 9
            AETLNAK V
Sbjct: 1010 AETLNAKAV 1018



>XP_005247549
          Length = 1924

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AETLNAKTV 9
            AETLNAK V
Sbjct: 1010 AETLNAKAV 1018



>NP_002462
          Length = 1939

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AETLNAKTV 9
          AET N KTV
Sbjct: 61 AETENGKTV 69



>NP_001269480
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 215 ETLNAKEI 222



>NP_001269479
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 215 ETLNAKEI 222



>NP_055777
          Length = 522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 276 ETLNAKEI 283



>NP_001269483
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 125 ETLNAKEI 132



>NP_001269481
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 125 ETLNAKEI 132



>NP_848526
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ET+N KTV
Sbjct: 206 ETVNVKTV 213



>NP_852108
          Length = 565

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 319 ETLNAKEI 326



>XP_006723614
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 215 ETLNAKEI 222



>XP_006723613
          Length = 522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           ETLNAK +
Sbjct: 276 ETLNAKEI 283



>XP_005267752
          Length = 993

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AETLNAKTV 9
           AET N KTV
Sbjct: 101 AETENGKTV 109



>XP_006720215
          Length = 1968

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AETLNAKTV 9
          AET N KTV
Sbjct: 90 AETENGKTV 98



>XP_006720214
          Length = 1978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AETLNAKTV 9
           AET N KTV
Sbjct: 100 AETENGKTV 108



>XP_005267751
          Length = 1979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AETLNAKTV 9
           AET N KTV
Sbjct: 101 AETENGKTV 109



>NP_038203
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ETLNAKTV 9
            +TLN KTV
Sbjct: 1244 KTLNMKTV 1251



>NP_002152
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ETLNAKTV 9
            +TLN KTV
Sbjct: 1244 KTLNMKTV 1251



>NP_898885
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETLNAKTV 9
           + LNAKTV
Sbjct: 233 DILNAKTV 240



>XP_005260134
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ETLNAK 7
          ETLNAK
Sbjct: 30 ETLNAK 35



>XP_005260133
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLNAK 7
           ETLNAK
Sbjct: 234 ETLNAK 239



>NP_077011
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLNAK 7
           ETLNAK
Sbjct: 272 ETLNAK 277



>NP_114479
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ETLNAKTV 9
           E++NAKT+
Sbjct: 839 ESVNAKTL 846



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.107    0.248 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 295,276
Number of extensions: 361
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)