Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     509
XP_006717990                                                           20     509
XP_006717989                                                           20     509
NP_001265045                                                           17    4312
NP_001137435                                                           17    4312
NP_076493                                                              17    4312
NP_000416                                                              17    4312
NP_001074012                                                           16    5631
NP_067054                                                              16    5631
NP_002369                                                              16    5631
NP_001166144                                                           16    5631
XP_005255915                                                           16    5631
XP_005251238                                                           16    5631
XP_005251237                                                           16    5631
NP_620419                                                              16    5631
NP_057079                                                              16    5631
NP_001070                                                              16    7355
NP_997402                                                              16    7355
NP_110421                                                              16    7355
NP_001139542                                                           16    7355
NP_001139543                                                           16    7355
NP_000740                                                              16    7355
NP_000014                                                              16    7355
NP_955378                                                              16    7355
XP_005257631                                                           16    7355
XP_006722077                                                           16    7355
XP_005266617                                                           16    7355
XP_005266615                                                           16    7355
XP_005266614                                                           16    7355
XP_005266613                                                           16    7355
XP_006712792                                                           16    7355
XP_006712791                                                           16    7355
XP_005264072                                                           16    7355
XP_006712070                                                           16    7355
XP_005264349                                                           16    7355
NP_116165                                                              15    9605
NP_001269877                                                           15    9605
NP_002935                                                              15    9605
NP_937821                                                              15    9605
NP_001026881                                                           15    9605
NP_001161840                                                           15    9605
NP_004472                                                              15    9605
NP_065743                                                              15    9605
XP_005269685                                                           15    9605
XP_005269684                                                           15    9605
XP_005269683                                                           15    9605
XP_005269681                                                           15    9605
XP_006717770                                                           15    9605
XP_005269679                                                           15    9605
XP_005251128                                                           15    9605
XP_005251127                                                           15    9605
XP_005251126                                                           15    9605
XP_006715611                                                           15    9605
XP_006714955                                                           15    9605
XP_005265867                                                           15    9605
XP_005265868                                                           15    9605
XP_005265869                                                           15    9605
XP_005265866                                                           15    9605
XP_005265865                                                           15    9605
XP_005265864                                                           15    9605
NP_001124336                                                           15    9605
>NP_000305
          Length = 403

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AERREGVYR 9
          AER EGVYR
Sbjct: 39 AERLEGVYR 47
>XP_006717990
          Length = 175

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AERREGVYR 9
          AER EGVYR
Sbjct: 39 AERLEGVYR 47
>XP_006717989
          Length = 388

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AERREGVYR 9
          AER EGVYR
Sbjct: 39 AERLEGVYR 47
>NP_001265045
          Length = 1257

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AERREGVYR 9
           A+R +G+YR
Sbjct: 105 AQRFQGIYR 113
>NP_001137435
          Length = 1248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AERREGVYR 9
           A+R +G+YR
Sbjct: 100 AQRFQGIYR 108
>NP_076493
          Length = 1253

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AERREGVYR 9
           A+R +G+YR
Sbjct: 105 AQRFQGIYR 113
>NP_000416
          Length = 1257

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AERREGVYR 9
           A+R +G+YR
Sbjct: 105 AQRFQGIYR 113
>NP_001074012
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERREGV 7
           ERREGV
Sbjct: 389 ERREGV 394
>NP_067054
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERREGV 7
           ERREGV
Sbjct: 389 ERREGV 394
>NP_002369
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AERREG 6
          AERREG
Sbjct: 7  AERREG 12
>NP_001166144
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++REGV+R
Sbjct: 367 QQREGVWR 374
>XP_005255915
          Length = 1099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RREGVYR 9
          +R+GVYR
Sbjct: 9  QRDGVYR 15
>XP_005251238
          Length = 160

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RREGVYR 9
           ++EGVYR
Sbjct: 101 QKEGVYR 107
>XP_005251237
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RREGVYR 9
           ++EGVYR
Sbjct: 101 QKEGVYR 107
>NP_620419
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RREGVYR 9
           ++EGVYR
Sbjct: 101 QKEGVYR 107
>NP_057079
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AERREG 6
          AERREG
Sbjct: 81 AERREG 86
>NP_001070
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   REGVYR 9
           R+GVYR
Sbjct: 353 RQGVYR 358
>NP_997402
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  REGVYR 9
          R+GVYR
Sbjct: 46 RQGVYR 51
>NP_110421
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 185 KHEGVYR 191
>NP_001139542
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 278 KHEGVYR 284
>NP_001139543
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 185 KHEGVYR 191
>NP_000740
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RREGVY 8
           RR+GVY
Sbjct: 213 RRDGVY 218
>NP_000014
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RREGVY 8
           R+EGVY
Sbjct: 192 RKEGVY 197
>NP_955378
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RREGVY 8
          RREG+Y
Sbjct: 60 RREGLY 65
>XP_005257631
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RREGVY 8
          R+EGVY
Sbjct: 90 RKEGVY 95
>XP_006722077
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RREGVY 8
           R+EGVY
Sbjct: 246 RKEGVY 251
>XP_005266617
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 185 KHEGVYR 191
>XP_005266615
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 278 KHEGVYR 284
>XP_005266614
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 278 KHEGVYR 284
>XP_005266613
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RREGVYR 9
           + EGVYR
Sbjct: 278 KHEGVYR 284
>XP_006712792
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  REGVYR 9
          R+GVYR
Sbjct: 46 RQGVYR 51
>XP_006712791
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   REGVYR 9
           R+GVYR
Sbjct: 353 RQGVYR 358
>XP_005264072
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   REGVYR 9
           R+GVYR
Sbjct: 347 RQGVYR 352
>XP_006712070
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RREGVY 8
          RREG+Y
Sbjct: 60 RREGLY 65
>XP_005264349
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RREGVY 8
          RREG+Y
Sbjct: 60 RREGLY 65
>NP_116165
          Length = 2540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1218 ERKEGSY 1224
>NP_001269877
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1036 ERKEGSY 1042
>NP_002935
          Length = 2347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   REGVYR 9
           R+G+YR
Sbjct: 428 RDGIYR 433
>NP_937821
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AERREGVYR 9
          A+R++G Y+
Sbjct: 27 AQRQQGFYK 35
>NP_001026881
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERREGVYR 9
           ERR+ +YR
Sbjct: 244 ERRQPLYR 251
>NP_001161840
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERREGVYR 9
           +RREG+ R
Sbjct: 186 DRREGLIR 193
>NP_004472
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERREGVYR 9
           +RREG+ R
Sbjct: 199 DRREGLMR 206
>NP_065743
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERREGVYR 9
           +RREG+ R
Sbjct: 186 DRREGLIR 193
>XP_005269685
          Length = 1700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1218 ERKEGSY 1224
>XP_005269684
          Length = 2032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1218 ERKEGSY 1224
>XP_005269683
          Length = 2252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ERREGVY 8
           ER+EG Y
Sbjct: 930 ERKEGSY 936
>XP_005269681
          Length = 2321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 999  ERKEGSY 1005
>XP_006717770
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1036 ERKEGSY 1042
>XP_005269679
          Length = 2502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ERREGVY 8
            ER+EG Y
Sbjct: 1180 ERKEGSY 1186
>XP_005251128
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AERREGVYR 9
          A+R+EG  R
Sbjct: 5  AQRKEGAVR 13
>XP_005251127
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AERREGVYR 9
          A+R+EG  R
Sbjct: 5  AQRKEGAVR 13
>XP_005251126
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AERREGVYR 9
          A+R+EG  R
Sbjct: 5  AQRKEGAVR 13
>XP_006715611
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   REGVYR 9
           R+G+YR
Sbjct: 437 RDGIYR 442
>XP_006714955
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERREGVYR 9
           ERR+ +YR
Sbjct: 152 ERRQPLYR 159
>XP_005265867
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>XP_005265868
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>XP_005265869
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>XP_005265866
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>XP_005265865
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>XP_005265864
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 505 KKRKGLYR 512
>NP_001124336
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERREGVYR 9
           ++R+G+YR
Sbjct: 722 KKRKGLYR 729
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.138    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 628,556
Number of extensions: 1079
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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