Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              19     665
NP_054722                                                              17    2528
XP_005256326                                                           17    2528
NP_940861                                                              17    3301
NP_001243333                                                           17    3301
NP_000736                                                              17    4312
NP_000740                                                              17    4312
XP_005254199                                                           17    4312
NP_000737                                                              16    5631
NP_001177384                                                           16    5631
NP_001155244                                                           16    5631
NP_000860                                                              16    5631
NP_998786                                                              16    5631
NP_037495                                                              16    5631
NP_000733                                                              16    7355
NP_001073901                                                           16    7355
NP_000735                                                              16    7355
NP_001273171                                                           16    7355
NP_653321                                                              16    7355
NP_001092903                                                           16    7355
NP_001511                                                              16    7355
NP_004932                                                              16    7355
NP_001252539                                                           16    7355
NP_001252538                                                           16    7355
NP_001269384                                                           16    7355
NP_001257863                                                           16    7355
NP_001036111                                                           16    7355
NP_055780                                                              16    7355
NP_055605                                                              16    7355
NP_060051                                                              16    7355
NP_001257870                                                           16    7355
NP_001252537                                                           16    7355
NP_001269211                                                           16    7355
NP_001098991                                                           16    7355
XP_005257171                                                           16    7355
XP_005257170                                                           16    7355
XP_006721105                                                           16    7355
XP_006717843                                                           16    7355
XP_005252734                                                           16    7355
XP_005252733                                                           16    7355
XP_005252732                                                           16    7355
XP_005252731                                                           16    7355
XP_005252730                                                           16    7355
XP_005252729                                                           16    7355
XP_006716345                                                           16    7355
XP_005265021                                                           16    7355
XP_006713094                                                           16    7355
XP_006713093                                                           16    7355
XP_005265020                                                           16    7355
XP_006713092                                                           16    7355
XP_005265019                                                           16    7355
XP_006713091                                                           16    7355
XP_005265017                                                           16    7355
XP_005265016                                                           16    7355
XP_005265015                                                           16    7355
XP_005265014                                                           16    7355
XP_005265013                                                           16    7355
NP_001035194                                                           16    7355
NP_006787                                                              15    9605
NP_006779                                                              15    9605
NP_000231                                                              15    9605
NP_001257387                                                           15    9605
NP_001001570                                                           15    9605
NP_065961                                                              15    9605
NP_001158137                                                           15    9605
NP_001231681                                                           15    9605
XP_006722359                                                           15    9605
XP_006722358                                                           15    9605
XP_006716835                                                           15    9605
XP_006716834                                                           15    9605
XP_006716833                                                           15    9605
XP_006716832                                                           15    9605
XP_006716812                                                           15    9605
XP_006716135                                                           15    9605
XP_006716134                                                           15    9605
NP_671728                                                              15    9605
>NP_055365
          Length = 1032

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AERNELLTT 9
           AER+ELLTT
Sbjct: 428 AERDELLTT 436
>NP_054722
          Length = 1227

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           A +NELLTT
Sbjct: 873 AYKNELLTT 881
>XP_005256326
          Length = 1192

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           A +NELLTT
Sbjct: 838 AYKNELLTT 846
>NP_940861
          Length = 871

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ERNE+LT
Sbjct: 740 ERNEILT 746
>NP_001243333
          Length = 928

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ERNE+LT
Sbjct: 797 ERNEILT 803
>NP_000736
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N+L+TT
Sbjct: 88 EKNQLMTT 95
>NP_000740
          Length = 458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N+L+TT
Sbjct: 70 EKNQLMTT 77
>XP_005254199
          Length = 243

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N+L+TT
Sbjct: 88 EKNQLMTT 95
>NP_000737
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N++LTT
Sbjct: 67 EKNQVLTT 74
>NP_001177384
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ERNELLTT 9
           E+N++LTT
Sbjct: 96  EKNQVLTT 103
>NP_001155244
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N++LTT
Sbjct: 60 EKNQVLTT 67
>NP_000860
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N++LTT
Sbjct: 81 EKNQVLTT 88
>NP_998786
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N++LTT
Sbjct: 81 EKNQVLTT 88
>NP_037495
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AERNELL 7
           +ERNELL
Sbjct: 241 SERNELL 247
>NP_000733
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERNELLTT 9
           E+N+++TT
Sbjct: 100 EKNQMMTT 107
>NP_001073901
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           +RNE+LT
Sbjct: 430 QRNEILT 436
>NP_000735
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N+++TT
Sbjct: 78 EKNQMMTT 85
>NP_001273171
          Length = 2084

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RNELLTT 9
           R+ELLTT
Sbjct: 449 RSELLTT 455
>NP_653321
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 314 ERNELL 319
>NP_001092903
          Length = 831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 314 ERNELL 319
>NP_001511
          Length = 2109

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RNELLTT 9
           R+ELLTT
Sbjct: 449 RSELLTT 455
>NP_004932
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           A R+E+LTT
Sbjct: 907 AYRDEMLTT 915
>NP_001252539
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 71 ERNELL 76
>NP_001252538
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 71 ERNELL 76
>NP_001269384
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ERNELLTT 9
          E+N+++TT
Sbjct: 85 EKNQMMTT 92
>NP_001257863
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 308 ERNELL 313
>NP_001036111
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>NP_055780
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 87 ERNELL 92
>NP_055605
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 308 ERNELL 313
>NP_060051
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ERNELLT 8
          ERN++LT
Sbjct: 72 ERNQILT 78
>NP_001257870
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 308 ERNELL 313
>NP_001252537
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>NP_001269211
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 266 ERNELL 271
>NP_001098991
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005257171
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           A R+E+LTT
Sbjct: 907 AYRDEMLTT 915
>XP_005257170
          Length = 1218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           A R+E+LTT
Sbjct: 905 AYRDEMLTT 913
>XP_006721105
          Length = 2046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RNELLTT 9
           R+ELLTT
Sbjct: 449 RSELLTT 455
>XP_006717843
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005252734
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005252733
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 245 ERNELL 250
>XP_005252732
          Length = 976

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005252731
          Length = 988

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005252730
          Length = 990

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_005252729
          Length = 990

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 319 ERNELL 324
>XP_006716345
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERNELLTT 9
           E+N+++TT
Sbjct: 100 EKNQMMTT 107
>XP_005265021
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_006713094
          Length = 643

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_006713093
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_005265020
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_006713092
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_005265019
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_006713091
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_005265017
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>XP_005265016
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 41 ERNELL 46
>XP_005265015
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 71 ERNELL 76
>XP_005265014
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ERNELL 7
          ERNELL
Sbjct: 87 ERNELL 92
>XP_005265013
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ERNELL 7
           ERNELL
Sbjct: 145 ERNELL 150
>NP_001035194
          Length = 4493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AERNELLTT 9
            +ER+ LLTT
Sbjct: 3810 SERSTLLTT 3818
>NP_006787
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AERNELLT 8
          A RN LLT
Sbjct: 49 ASRNSLLT 56
>NP_006779
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AERNELLT 8
           A+ NE+LT
Sbjct: 484 AQENEILT 491
>NP_000231
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AERNELL 7
           AERN+L+
Sbjct: 289 AERNQLI 295
>NP_001257387
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AERNELL 7
           AERN+L+
Sbjct: 156 AERNQLI 162
>NP_001001570
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AERNELL 7
          +ERNEL+
Sbjct: 71 SERNELI 77
>NP_065961
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AERNELLTT 9
            AE++ L+TT
Sbjct: 1614 AEKDRLITT 1622
>NP_001158137
          Length = 1950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AERNELLTT 9
            AE++ L+TT
Sbjct: 1614 AEKDRLITT 1622
>NP_001231681
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 475 DKNELLT 481
>XP_006722359
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AERNELLT 8
           A+ NE+LT
Sbjct: 484 AQENEILT 491
>XP_006722358
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AERNELLT 8
           A+ NE+LT
Sbjct: 484 AQENEILT 491
>XP_006716835
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 448 DKNELLT 454
>XP_006716834
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 476 DKNELLT 482
>XP_006716833
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 494 DKNELLT 500
>XP_006716832
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 494 DKNELLT 500
>XP_006716812
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 485 DKNELLT 491
>XP_006716135
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AERNELLTT 9
           AE++ L+TT
Sbjct: 398 AEKDRLITT 406
>XP_006716134
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AERNELLTT 9
            AE++ L+TT
Sbjct: 1511 AEKDRLITT 1519
>NP_671728
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ERNELLT 8
           ++NELLT
Sbjct: 467 DKNELLT 473
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.117    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 465,237
Number of extensions: 712
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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