Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
XP_005267290                                                           19     869
NP_005742                                                              17    4312
NP_671714                                                              17    4312
XP_006715890                                                           17    4312
XP_005250160                                                           17    4312
XP_005250159                                                           17    4312
NP_078963                                                              16    5631
NP_001186131                                                           16    5631
NP_001186130                                                           16    5631
XP_005247836                                                           16    5631
XP_006713811                                                           16    5631
XP_006713810                                                           16    5631
XP_005247834                                                           16    5631
NP_055640                                                              16    7355
XP_005268396                                                           16    7355
XP_005268394                                                           16    7355
XP_005268395                                                           16    7355
XP_005275799                                                           16    7355
XP_005275797                                                           16    7355
XP_005275798                                                           16    7355
XP_006710032                                                           16    7355
XP_005275796                                                           16    7355
NP_003795                                                              15    9605
NP_056306                                                              15    9605
NP_116259                                                              15    9605
NP_065145                                                              15    9605
NP_001229827                                                           15    9605
NP_659436                                                              15    9605
NP_891552                                                              15    9605
XP_005262017                                                           15    9605
XP_006724497                                                           15    9605
XP_006724496                                                           15    9605
XP_006724495                                                           15    9605
XP_006724494                                                           15    9605
XP_006724493                                                           15    9605
XP_006724492                                                           15    9605
XP_006724491                                                           15    9605
XP_005262014                                                           15    9605
XP_005262013                                                           15    9605
XP_006722338                                                           15    9605
XP_005256070                                                           15    9605
XP_006715515                                                           15    9605
XP_006715514                                                           15    9605
XP_006715513                                                           15    9605
XP_005266974                                                           15    9605
XP_005266973                                                           15    9605
XP_005266972                                                           15    9605
XP_005266971                                                           15    9605
XP_005266970                                                           15    9605
XP_005266969                                                           15    9605
XP_005249515                                                           15    9605
XP_006715299                                                           15    9605
XP_005249514                                                           15    9605
NP_659453                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AEQNELSLQ 9
          AEQ+ELSLQ
Sbjct: 69 AEQDELSLQ 77
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AEQNELSLQ 9
          AEQ+ELSLQ
Sbjct: 69 AEQDELSLQ 77
>NP_005742
          Length = 3907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AEQNELSLQ 9
            +EQN+L LQ
Sbjct: 1104 SEQNDLRLQ 1112
>NP_671714
          Length = 3899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AEQNELSLQ 9
            +EQN+L LQ
Sbjct: 1104 SEQNDLRLQ 1112
>XP_006715890
          Length = 3860

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AEQNELSLQ 9
            +EQN+L LQ
Sbjct: 1104 SEQNDLRLQ 1112
>XP_005250160
          Length = 3939

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AEQNELSLQ 9
            +EQN+L LQ
Sbjct: 1104 SEQNDLRLQ 1112
>XP_005250159
          Length = 3952

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AEQNELSLQ 9
            +EQN+L LQ
Sbjct: 1104 SEQNDLRLQ 1112
>NP_078963
          Length = 800

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 683 DQNELSL 689
>NP_001186131
          Length = 771

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 654 DQNELSL 660
>NP_001186130
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 722 DQNELSL 728
>XP_005247836
          Length = 627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 510 DQNELSL 516
>XP_006713811
          Length = 800

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 683 DQNELSL 689
>XP_006713810
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 721 DQNELSL 727
>XP_005247834
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EQNELSL 8
           +QNELSL
Sbjct: 722 DQNELSL 728
>NP_055640
          Length = 2271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    EQNELSL 8
            EQN+LSL
Sbjct: 1552 EQNKLSL 1558
>XP_005268396
          Length = 1603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 627 ESNEISMQ 634
>XP_005268394
          Length = 1603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 627 ESNEISMQ 634
>XP_005268395
          Length = 1603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 627 ESNEISMQ 634
>XP_005275799
          Length = 1680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 628 ESNEISMQ 635
>XP_005275797
          Length = 1680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 628 ESNEISMQ 635
>XP_005275798
          Length = 1680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 628 ESNEISMQ 635
>XP_006710032
          Length = 1694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 642 ESNEISMQ 649
>XP_005275796
          Length = 1733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E NE+S+Q
Sbjct: 681 ESNEISMQ 688
>NP_003795
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E+NE SLQ
Sbjct: 368 EENEPSLQ 375
>NP_056306
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 462 EQNSLSL 468
>NP_116259
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 462 EQNSLSL 468
>NP_065145
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AEQNELS 7
           AEQ+ELS
Sbjct: 183 AEQDELS 189
>NP_001229827
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>NP_659436
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEQNELSL 8
           AEQ +LSL
Sbjct: 329 AEQEQLSL 336
>NP_891552
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           + NE+SLQ
Sbjct: 139 DSNEMSLQ 146
>XP_005262017
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 314 NELSLQ 319
>XP_006724497
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>XP_006724496
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>XP_006724495
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>XP_006724494
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>XP_006724493
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 555 NELSLQ 560
>XP_006724492
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 577 NELSLQ 582
>XP_006724491
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 577 NELSLQ 582
>XP_005262014
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 617 NELSLQ 622
>XP_005262013
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NELSLQ 9
           NELSLQ
Sbjct: 617 NELSLQ 622
>XP_006722338
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEQNELSL 8
           AEQ +LSL
Sbjct: 329 AEQEQLSL 336
>XP_005256070
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EQNELSLQ 9
          + NE+SLQ
Sbjct: 53 DSNEMSLQ 60
>XP_006715515
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 367 EQNSLSL 373
>XP_006715514
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 367 EQNSLSL 373
>XP_006715513
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 367 EQNSLSL 373
>XP_005266974
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 462 EQNSLSL 468
>XP_005266973
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 462 EQNSLSL 468
>XP_005266972
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 462 EQNSLSL 468
>XP_005266971
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 507 EQNSLSL 513
>XP_005266970
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 525 EQNSLSL 531
>XP_005266969
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EQNELSL 8
           EQN LSL
Sbjct: 525 EQNSLSL 531
>XP_005249515
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E+NE SLQ
Sbjct: 368 EENEPSLQ 375
>XP_006715299
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E+NE SLQ
Sbjct: 409 EENEPSLQ 416
>XP_005249514
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQNELSLQ 9
           E+NE SLQ
Sbjct: 538 EENEPSLQ 545
>NP_659453
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AEQNELSLQ 9
           A+ NE SLQ
Sbjct: 261 ADNNEKSLQ 269
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.289    0.108    0.239 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 415,313
Number of extensions: 473
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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