Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_006181                                                              17    4312
XP_006712618                                                           17    4312
XP_006710156                                                           17    4312
NP_001129651                                                           16    5631
NP_001129649                                                           16    5631
NP_000390                                                              16    5631
NP_001129650                                                           16    5631
NP_001013421                                                           16    5631
NP_002408                                                              16    5631
NP_001165775                                                           16    5631
NP_001139438                                                           16    5631
NP_116233                                                              16    5631
NP_001165774                                                           16    5631
NP_054731                                                              16    5631
NP_001363                                                              16    5631
XP_005260461                                                           16    5631
XP_006721530                                                           16    5631
XP_006721529                                                           16    5631
XP_006721528                                                           16    5631
XP_005269647                                                           16    5631
XP_006717583                                                           16    5631
XP_005252689                                                           16    5631
XP_005252688                                                           16    5631
XP_006717582                                                           16    5631
XP_005252687                                                           16    5631
XP_006717581                                                           16    5631
NP_689759                                                              16    5631
NP_001161819                                                           16    7355
NP_683759                                                              16    7355
NP_060514                                                              16    7355
NP_056273                                                              16    7355
NP_001186947                                                           16    7355
NP_036323                                                              16    7355
NP_001186945                                                           16    7355
XP_005277661                                                           16    7355
NP_001245210                                                           15    9605
NP_000242                                                              15    9605
NP_001274103                                                           15    9605
NP_000343                                                              15    9605
NP_001139280                                                           15    9605
NP_000623                                                              15    9605
NP_001035247                                                           15    9605
XP_006718349                                                           15    9605
XP_006714391                                                           15    9605
XP_006714390                                                           15    9605
XP_005264389                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AELAKTPVH 9
            AELAKTPV+
Sbjct: 3594 AELAKTPVN 3602
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AELAKTPVH 9
            AELAKTPV+
Sbjct: 3594 AELAKTPVN 3602
>NP_006181
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AELAKTP 7
           +ELAKTP
Sbjct: 111 SELAKTP 117
>XP_006712618
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AELAKTP 7
           +ELAKTP
Sbjct: 111 SELAKTP 117
>XP_006710156
          Length = 343

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           A+ A+TP H
Sbjct: 102 AQAARTPTH 110
>NP_001129651
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKTPVH 9
           +KTPVH
Sbjct: 281 SKTPVH 286
>NP_001129649
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKTPVH 9
           +KTPVH
Sbjct: 331 SKTPVH 336
>NP_000390
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKTPVH 9
           +KTPVH
Sbjct: 331 SKTPVH 336
>NP_001129650
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKTPVH 9
           +KTPVH
Sbjct: 331 SKTPVH 336
>NP_001013421
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ELAKTPVH 9
           ELAK P H
Sbjct: 235 ELAKPPKH 242
>NP_002408
          Length = 3256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AELAKTPV 8
           AE+ KTPV
Sbjct: 756 AEMFKTPV 763
>NP_001165775
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>NP_001139438
          Length = 2896

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AELAKTPV 8
           AE+ KTPV
Sbjct: 396 AEMFKTPV 403
>NP_116233
          Length = 878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>NP_001165774
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>NP_054731
          Length = 298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AKTPVH 9
          AKTP+H
Sbjct: 9  AKTPLH 14
>NP_001363
          Length = 4486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AEL  +PVH
Sbjct: 593 AELGFSPVH 601
>XP_005260461
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AKTPVH 9
          AKTP+H
Sbjct: 9  AKTPLH 14
>XP_006721530
          Length = 2746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AEL  +PVH
Sbjct: 593 AELGFSPVH 601
>XP_006721529
          Length = 2817

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AEL  +PVH
Sbjct: 593 AELGFSPVH 601
>XP_006721528
          Length = 3869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AEL  +PVH
Sbjct: 593 AELGFSPVH 601
>XP_005269647
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKTPVH 9
           +KTPVH
Sbjct: 344 SKTPVH 349
>XP_006717583
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>XP_005252689
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>XP_005252688
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>XP_006717582
          Length = 850

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>XP_005252687
          Length = 883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>XP_006717581
          Length = 884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELAKTPVH 9
           ELA +P+H
Sbjct: 366 ELALSPIH 373
>NP_689759
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LAKTPVH 9
           LAK P+H
Sbjct: 176 LAKKPIH 182
>NP_001161819
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AELA+  VH
Sbjct: 104 AELARLKVH 112
>NP_683759
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AELA+  VH
Sbjct: 104 AELARLKVH 112
>NP_060514
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AELA+  VH
Sbjct: 104 AELARLKVH 112
>NP_056273
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  AELAKTP 7
          AEL KTP
Sbjct: 4  AELIKTP 10
>NP_001186947
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  AELAKTPVH 9
          AEL   PVH
Sbjct: 58 AELTLEPVH 66
>NP_036323
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  AELAKTPVH 9
          AEL   PVH
Sbjct: 80 AELTLEPVH 88
>NP_001186945
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  AELAKTPVH 9
          AEL   PVH
Sbjct: 58 AELTLEPVH 66
>XP_005277661
          Length = 381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AELAKTPVH 9
           AELA+  VH
Sbjct: 104 AELARLKVH 112
>NP_001245210
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AELA  P H
Sbjct: 765 AELANFPKH 773
>NP_000242
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AELA  P H
Sbjct: 831 AELANFPKH 839
>NP_001274103
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ELAKTPVH 9
            ++AK P+H
Sbjct: 1409 DIAKLPLH 1416
>NP_000343
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ELAKTPVH 9
            ++AK P+H
Sbjct: 1408 DIAKLPLH 1415
>NP_001139280
          Length = 1153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    AELAKTPV 8
            AEL K PV
Sbjct: 1013 AELRKAPV 1020
>NP_000623
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    AELAKTPV 8
            AEL K PV
Sbjct: 1012 AELRKAPV 1019
>NP_001035247
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AEL K P H
Sbjct: 380 AELLKCPNH 388
>XP_006718349
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ELAKTPVH 9
            ++AK P+H
Sbjct: 1408 DIAKLPLH 1415
>XP_006714391
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AEL K P H
Sbjct: 380 AELLKCPNH 388
>XP_006714390
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AEL K P H
Sbjct: 380 AELLKCPNH 388
>XP_005264389
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AELAKTPVH 9
           AELA  P H
Sbjct: 831 AELANFPKH 839
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.121    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 633,232
Number of extensions: 557
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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