Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     665
NP_444254                                                              19     665
NP_444253                                                              19     665
NP_444255                                                              19     665
NP_444260                                                              19     665
NP_444259                                                              19     665
XP_005247551                                                           19     665
XP_005247550                                                           19     665
XP_006713712                                                           19     665
XP_005247549                                                           19     665
NP_001269828                                                           17    2528
NP_001269829                                                           17    2528
NP_001269830                                                           17    2528
NP_001093867                                                           17    2528
NP_008954                                                              17    2528
XP_006712269                                                           17    2528
XP_006712268                                                           17    2528
XP_005246303                                                           17    2528
NP_001159921                                                           17    3301
NP_002209                                                              17    3301
NP_001157961                                                           17    4312
NP_001100                                                              17    4312
NP_006238                                                              17    4312
NP_001157962                                                           17    4312
NP_001191213                                                           17    4312
XP_006717797                                                           17    4312
XP_005252713                                                           17    4312
XP_005252712                                                           17    4312
NP_056005                                                              17    4312
NP_817123                                                              16    5631
NP_001127925                                                           16    5631
NP_036218                                                              16    7355
NP_775922                                                              16    7355
XP_005247022                                                           16    7355
NP_001121782                                                           15    9605
NP_004675                                                              15    9605
NP_004658                                                              15    9605
NP_001157262                                                           15    9605
NP_005147                                                              15    9605
NP_001231827                                                           15    9605
NP_001073876                                                           15    9605
NP_001157260                                                           15    9605
NP_001231826                                                           15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_006718823                                                           15    9605
XP_006717409                                                           15    9605
XP_006717408                                                           15    9605
XP_006717407                                                           15    9605
XP_006717406                                                           15    9605
XP_006710312                                                           15    9605
>NP_444256
          Length = 1794

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1671 DVSQAFLE 1678
>NP_444254
          Length = 1845

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1722 DVSQAFLE 1729
>NP_444253
          Length = 1914

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1791 DVSQAFLE 1798
>NP_444255
          Length = 1863

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1740 DVSQAFLE 1747
>NP_444260
          Length = 154

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  DVSQAFLE 9
          DVSQAFLE
Sbjct: 31 DVSQAFLE 38
>NP_444259
          Length = 153

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  DVSQAFLE 9
          DVSQAFLE
Sbjct: 30 DVSQAFLE 37
>XP_005247551
          Length = 1855

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1732 DVSQAFLE 1739
>XP_005247550
          Length = 1856

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1733 DVSQAFLE 1740
>XP_006713712
          Length = 1923

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1800 DVSQAFLE 1807
>XP_005247549
          Length = 1924

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    DVSQAFLE 9
            DVSQAFLE
Sbjct: 1801 DVSQAFLE 1808
>NP_001269828
          Length = 858

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 443 DVSMAFLE 450
>NP_001269829
          Length = 840

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 425 DVSMAFLE 432
>NP_001269830
          Length = 791

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 376 DVSMAFLE 383
>NP_001093867
          Length = 867

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 452 DVSMAFLE 459
>NP_008954
          Length = 1011

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 596 DVSMAFLE 603
>XP_006712269
          Length = 838

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 423 DVSMAFLE 430
>XP_006712268
          Length = 840

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 425 DVSMAFLE 432
>XP_005246303
          Length = 993

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 578 DVSMAFLE 585
>NP_001159921
          Length = 900

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 420 DVSYAFLE 427
>NP_002209
          Length = 930

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DVS AFLE
Sbjct: 420 DVSYAFLE 427
>NP_001157961
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           +D SQA+LE
Sbjct: 377 SDCSQAYLE 385
>NP_001100
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           +D SQA+LE
Sbjct: 377 SDCSQAYLE 385
>NP_006238
          Length = 499

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DVSQAFLE 9
           DV++AFLE
Sbjct: 409 DVTKAFLE 416
>NP_001157962
          Length = 733

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           +D SQA+LE
Sbjct: 338 SDCSQAYLE 346
>NP_001191213
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DVSQAFLE 9
           DV++AFLE
Sbjct: 387 DVTKAFLE 394
>XP_006717797
          Length = 238

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           AD+ QA+L+
Sbjct: 128 ADIKQAYLD 136
>XP_005252713
          Length = 714

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           +D SQA+LE
Sbjct: 377 SDCSQAYLE 385
>XP_005252712
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           +D SQA+LE
Sbjct: 377 SDCSQAYLE 385
>NP_056005
          Length = 260

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           AD+ QA+L+
Sbjct: 128 ADIKQAYLD 136
>NP_817123
          Length = 1040

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           AD++ AFL+
Sbjct: 772 ADINMAFLD 780
>NP_001127925
          Length = 1059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADVSQAFLE 9
           AD++ AFL+
Sbjct: 791 ADINMAFLD 799
>NP_036218
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVSQAFLE 9
           DV++AFL+
Sbjct: 426 DVAEAFLD 433
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSQAFLE 9
           VSQAFL+
Sbjct: 527 VSQAFLD 533
>XP_005247022
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  DVSQAFLE 9
          DV++AFL+
Sbjct: 34 DVAEAFLD 41
>NP_001121782
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 365 SQAFLE 370
>NP_004675
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 365 SQAFLE 370
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVSQAFLE 9
            D SQAFL+
Sbjct: 1386 DHSQAFLQ 1393
>NP_001157262
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 98  SQAFLE 103
>NP_005147
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 95  SQAFLE 100
>NP_001231827
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 101 SQAFLE 106
>NP_001073876
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DV+Q FL+
Sbjct: 473 DVAQVFLD 480
>NP_001157260
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SQAFLE 9
          SQAFLE
Sbjct: 67 SQAFLE 72
>NP_001231826
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SQAFLE 9
          SQAFLE
Sbjct: 67 SQAFLE 72
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVSQAFLE 9
            D SQAFL+
Sbjct: 1300 DHSQAFLQ 1307
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVSQAFLE 9
            D SQAFL+
Sbjct: 1348 DHSQAFLQ 1355
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVSQAFLE 9
            D SQAFL+
Sbjct: 1348 DHSQAFLQ 1355
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVSQAFLE 9
            D SQAFL+
Sbjct: 1381 DHSQAFLQ 1388
>XP_006718823
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DVSQAFLE 9
           DV+Q FL+
Sbjct: 831 DVAQVFLD 838
>XP_006717409
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SQAFLE 9
          SQAFLE
Sbjct: 64 SQAFLE 69
>XP_006717408
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SQAFLE 9
          SQAFLE
Sbjct: 67 SQAFLE 72
>XP_006717407
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 98  SQAFLE 103
>XP_006717406
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQAFLE 9
           SQAFLE
Sbjct: 101 SQAFLE 106
>XP_006710312
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DVSQAFLE 9
          D SQAFL+
Sbjct: 54 DHSQAFLQ 61
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.125    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 323,103
Number of extensions: 437
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package