Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              20     299
XP_005248577                                                           20     299
XP_005248576                                                           20     299
NP_005206                                                              17    2528
XP_005258261                                                           17    2528
NP_004611                                                              17    3301
NP_665802                                                              17    3301
NP_065754                                                              17    3301
NP_001007528                                                           17    4312
NP_057675                                                              16    5631
NP_861441                                                              16    5631
NP_510968                                                              16    5631
XP_006714823                                                           16    5631
XP_006714822                                                           16    5631
XP_005268443                                                           16    5631
XP_005268434                                                           16    5631
XP_006714819                                                           16    5631
NP_789789                                                              16    7355
NP_001186217                                                           16    7355
NP_001186216                                                           16    7355
NP_001186215                                                           16    7355
NP_001186214                                                           16    7355
NP_001008489                                                           16    7355
NP_000706                                                              16    7355
NP_940999                                                              16    7355
XP_006724622                                                           16    7355
XP_005272727                                                           16    7355
XP_005273308                                                           16    7355
XP_005273309                                                           16    7355
NP_004913                                                              16    7355
NP_001243092                                                           15    9605
NP_001243095                                                           15    9605
NP_001157                                                              15    9605
NP_006197                                                              15    9605
NP_001069                                                              15    9605
NP_001186763                                                           15    9605
NP_542413                                                              15    9605
NP_001618                                                              15    9605
NP_002301                                                              15    9605
NP_001121143                                                           15    9605
NP_001230212                                                           15    9605
NP_001230210                                                           15    9605
NP_001230209                                                           15    9605
NP_001156                                                              15    9605
NP_892007                                                              15    9605
NP_055454                                                              15    9605
NP_056273                                                              15    9605
NP_056098                                                              15    9605
NP_955384                                                              15    9605
XP_005274042                                                           15    9605
XP_006718609                                                           15    9605
XP_006714104                                                           15    9605
XP_005265800                                                           15    9605
XP_006714103                                                           15    9605
XP_006714102                                                           15    9605
XP_005273301                                                           15    9605
NP_003263                                                              15    9605
>NP_005912
          Length = 1512

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DTILVKCA 9
           DTILVKCA
Sbjct: 685 DTILVKCA 692
>XP_005248577
          Length = 1349

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DTILVKCA 9
           DTILVKCA
Sbjct: 522 DTILVKCA 529
>XP_005248576
          Length = 1375

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DTILVKCA 9
           DTILVKCA
Sbjct: 548 DTILVKCA 555
>NP_005206
          Length = 1447

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           DT+L+KC
Sbjct: 155 DTVLLKC 161
>XP_005258261
          Length = 1447

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           DT+L+KC
Sbjct: 155 DTVLLKC 161
>NP_004611
          Length = 522

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           DT+LV+C
Sbjct: 491 DTLLVRC 497
>NP_665802
          Length = 522

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           DT+LV+C
Sbjct: 491 DTLLVRC 497
>NP_065754
          Length = 493

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           DT+++KC
Sbjct: 284 DTLIIKC 290
>NP_001007528
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DTIL KC
Sbjct: 269 DTILKKC 275
>NP_057675
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           D IL+KC
Sbjct: 417 DPILIKC 423
>NP_861441
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 104 ILVKCA 109
>NP_510968
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 97  ILVKCA 102
>XP_006714823
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 97  ILVKCA 102
>XP_006714822
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  ILVKCA 9
          ILVKCA
Sbjct: 19 ILVKCA 24
>XP_005268443
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 97  ILVKCA 102
>XP_005268434
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 104 ILVKCA 109
>XP_006714819
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILVKCA 9
           ILVKCA
Sbjct: 104 ILVKCA 109
>NP_789789
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           D+ILV+C
Sbjct: 383 DSILVQC 389
>NP_001186217
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADTILVKCA 9
          +DT +V+CA
Sbjct: 18 SDTWIVQCA 26
>NP_001186216
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADTILVKCA 9
          +DT +V+CA
Sbjct: 18 SDTWIVQCA 26
>NP_001186215
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADTILVKCA 9
          +DT +V+CA
Sbjct: 18 SDTWIVQCA 26
>NP_001186214
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADTILVKCA 9
          +DT +V+CA
Sbjct: 18 SDTWIVQCA 26
>NP_001008489
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADTILVKCA 9
          +DT +V+CA
Sbjct: 18 SDTWIVQCA 26
>NP_000706
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DTI+ KC
Sbjct: 261 DTIVFKC 267
>NP_940999
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           DT++ +CA
Sbjct: 869 DTLITQCA 876
>XP_006724622
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           D+ILV+C
Sbjct: 299 DSILVQC 305
>XP_005272727
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DTILVKC 8
           D+ILV+C
Sbjct: 325 DSILVQC 331
>XP_005273308
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DTI+ KC
Sbjct: 261 DTIVFKC 267
>XP_005273309
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DTI+ KC
Sbjct: 261 DTIVFKC 267
>NP_004913
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           DT++ +CA
Sbjct: 869 DTLITQCA 876
>NP_001243092
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DTILVK 7
           DTILVK
Sbjct: 511 DTILVK 516
>NP_001243095
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DTILVK 7
           DTILVK
Sbjct: 462 DTILVK 467
>NP_001157
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DTILVK 7
           DTILVK
Sbjct: 511 DTILVK 516
>NP_006197
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           +TI+V CA
Sbjct: 229 ETIVVTCA 236
>NP_001069
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DT+++ C
Sbjct: 617 DTVIISC 623
>NP_001186763
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DT+++ C
Sbjct: 555 DTVIISC 561
>NP_542413
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 2   DTILVKC 8
           DT+++ C
Sbjct: 525 DTVIISC 531
>NP_001618
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  DTILVKC 8
          DTI++ C
Sbjct: 37 DTIIIPC 43
>NP_002301
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADTILVK 7
           AD+ILVK
Sbjct: 737 ADSILVK 743
>NP_001121143
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADTILVK 7
           AD+ILVK
Sbjct: 737 ADSILVK 743
>NP_001230212
          Length = 133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  DTILVKC 8
          DTI++ C
Sbjct: 37 DTIIIPC 43
>NP_001230210
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  DTILVKC 8
          DTI++ C
Sbjct: 37 DTIIIPC 43
>NP_001230209
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  DTILVKC 8
          DTI++ C
Sbjct: 37 DTIIIPC 43
>NP_001156
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DTILVK 7
           DTILVK
Sbjct: 497 DTILVK 502
>NP_892007
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DTILVK 7
           DTILVK
Sbjct: 497 DTILVK 502
>NP_055454
          Length = 1564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ADTILVKCA 9
            A T+L KC+
Sbjct: 1107 AKTLLFKCS 1115
>NP_056273
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  TILVKC 8
          TI++KC
Sbjct: 68 TIIIKC 73
>NP_056098
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DTILVKCA 9
           DT+L  CA
Sbjct: 385 DTLLYTCA 392
>NP_955384
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTILVKCA 9
           A TILV C+
Sbjct: 193 APTILVYCS 201
>XP_005274042
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTILVKCA 9
           A TILV C+
Sbjct: 193 APTILVYCS 201
>XP_006718609
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTILVKCA 9
           A TILV C+
Sbjct: 223 APTILVYCS 231
>XP_006714104
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           +TI+V CA
Sbjct: 254 ETIVVTCA 261
>XP_005265800
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           +TI+V CA
Sbjct: 229 ETIVVTCA 236
>XP_006714103
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           +TI+V CA
Sbjct: 251 ETIVVTCA 258
>XP_006714102
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DTILVKCA 9
           +TI+V CA
Sbjct: 254 ETIVVTCA 261
>XP_005273301
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DTILVKCA 9
           DT+ V CA
Sbjct: 199 DTLFVLCA 206
>NP_003263
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DTILVKCA 9
           DT+ V CA
Sbjct: 199 DTLFVLCA 206
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.134    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 509,747
Number of extensions: 897
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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