Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              18    1135
XP_005248577                                                           18    1135
XP_005248576                                                           18    1135
NP_002118                                                              17    4312
NP_001014809                                                           17    4312
NP_001171658                                                           17    4312
NP_057021                                                              17    4312
XP_006725972                                                           17    4312
XP_006725763                                                           17    4312
XP_006725104                                                           17    4312
XP_006715143                                                           17    4312
XP_005247998                                                           17    4312
XP_005247997                                                           17    4312
NP_065878                                                              16    5631
XP_005263212                                                           16    5631
XP_005263211                                                           16    5631
XP_006710345                                                           16    5631
XP_006710344                                                           16    5631
XP_006710343                                                           16    5631
XP_006710342                                                           16    5631
NP_006305                                                              16    5631
NP_001278383                                                           16    7355
NP_055676                                                              16    7355
NP_001273456                                                           16    7355
NP_001245344                                                           16    7355
NP_065860                                                              16    7355
NP_001245347                                                           16    7355
NP_001245346                                                           16    7355
NP_001245345                                                           16    7355
NP_065931                                                              16    7355
XP_006723257                                                           16    7355
XP_006723256                                                           16    7355
XP_006721418                                                           16    7355
XP_005271685                                                           16    7355
XP_006718956                                                           16    7355
NP_002248                                                              15    9605
NP_954705                                                              15    9605
NP_056173                                                              15    9605
NP_001193849                                                           15    9605
XP_006724049                                                           15    9605
XP_006724048                                                           15    9605
XP_005258957                                                           15    9605
>NP_005912
          Length = 1512

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ADTATDVSK 9
            A TATDVSK
Sbjct: 995  AGTATDVSK 1003
>XP_005248577
          Length = 1349

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADTATDVSK 9
           A TATDVSK
Sbjct: 832 AGTATDVSK 840
>XP_005248576
          Length = 1375

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADTATDVSK 9
           A TATDVSK
Sbjct: 858 AGTATDVSK 866
>NP_002118
          Length = 338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTATDVSK 9
           ADTA  +SK
Sbjct: 160 ADTAAQISK 168
>NP_001014809
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DTATDVSK 9
          DTA+DVS+
Sbjct: 83 DTASDVSE 90
>NP_001171658
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DTATDVSK 9
           DT TDV K
Sbjct: 118 DTVTDVDK 125
>NP_057021
          Length = 578

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DTATDVSK 9
           DT TDV K
Sbjct: 118 DTVTDVDK 125
>XP_006725972
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTATDVSK 9
           ADTA  +SK
Sbjct: 160 ADTAAQISK 168
>XP_006725763
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTATDVSK 9
           ADTA  +SK
Sbjct: 160 ADTAAQISK 168
>XP_006725104
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTATDVSK 9
           ADTA  +SK
Sbjct: 160 ADTAAQISK 168
>XP_006715143
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTATDVSK 9
           ADTA  +SK
Sbjct: 160 ADTAAQISK 168
>XP_005247998
          Length = 689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DTATDVSK 9
          DTA+DVS+
Sbjct: 83 DTASDVSE 90
>XP_005247997
          Length = 713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DTATDVSK 9
          DTA+DVS+
Sbjct: 83 DTASDVSE 90
>NP_065878
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DTATDVS 8
           DT TDVS
Sbjct: 250 DTVTDVS 256
>XP_005263212
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DTATDVS 8
           DT TDVS
Sbjct: 250 DTVTDVS 256
>XP_005263211
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DTATDVS 8
           DT TDVS
Sbjct: 250 DTVTDVS 256
>XP_006710345
          Length = 455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADTATDVS 8
           ADT TD+S
Sbjct: 219 ADTLTDLS 226
>XP_006710344
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADTATDVS 8
           ADT TD+S
Sbjct: 484 ADTLTDLS 491
>XP_006710343
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADTATDVS 8
           ADT TD+S
Sbjct: 518 ADTLTDLS 525
>XP_006710342
          Length = 761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADTATDVS 8
           ADT TD+S
Sbjct: 525 ADTLTDLS 532
>NP_006305
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADTATDVS 8
           ADT TD+S
Sbjct: 477 ADTLTDLS 484
>NP_001278383
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 543 TGTDVSK 549
>NP_055676
          Length = 946

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 694 TGTDVSK 700
>NP_001273456
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 694 TGTDVSK 700
>NP_001245344
          Length = 1168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 740 TGTDVSK 746
>NP_065860
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 763 TGTDVSK 769
>NP_001245347
          Length = 1155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 727 TGTDVSK 733
>NP_001245346
          Length = 1155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 727 TGTDVSK 733
>NP_001245345
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 737 TGTDVSK 743
>NP_065931
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADTATDVS 8
          ADT+TD S
Sbjct: 83 ADTSTDKS 90
>XP_006723257
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADTATDVS 8
          ADT+TD S
Sbjct: 83 ADTSTDKS 90
>XP_006723256
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADTATDVS 8
          ADT+TD S
Sbjct: 83 ADTSTDKS 90
>XP_006721418
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 691 TGTDVSK 697
>XP_005271685
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 306 TGTDVSK 312
>XP_006718956
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TATDVSK 9
           T TDVSK
Sbjct: 763 TGTDVSK 769
>NP_002248
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ADTATDVSK 9
           ADT TD  K
Sbjct: 130 ADTITDAVK 138
>NP_954705
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TATDVSK 9
          TA+D+SK
Sbjct: 45 TASDISK 51
>NP_056173
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TATDVS 8
           TATDVS
Sbjct: 868 TATDVS 873
>NP_001193849
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TATDVS 8
           TATDVS
Sbjct: 237 TATDVS 242
>XP_006724049
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TATDVS 8
           TATDVS
Sbjct: 907 TATDVS 912
>XP_006724048
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TATDVS 8
           TATDVS
Sbjct: 797 TATDVS 802
>XP_005258957
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  ADTATDVSK 9
          ADT TD  K
Sbjct: 28 ADTITDAVK 36
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.292    0.104    0.248 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 369,103
Number of extensions: 595
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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