Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_065961                                                              18    1935
NP_001158137                                                           18    1935
XP_006716135                                                           18    1935
XP_006716134                                                           18    1935
NP_001161710                                                           17    4312
NP_001161709                                                           17    4312
NP_001161708                                                           17    4312
NP_009298                                                              17    4312
NP_005149                                                              17    4312
NP_001161711                                                           17    4312
XP_005245145                                                           17    4312
NP_001129472                                                           17    4312
NP_055524                                                              16    5631
XP_006712395                                                           16    5631
NP_786924                                                              16    5631
NP_001810                                                              16    7355
NP_001180                                                              16    7355
NP_001258973                                                           15    9605
NP_001258989                                                           15    9605
NP_003152                                                              15    9605
NP_001258972                                                           15    9605
NP_001258971                                                           15    9605
NP_004658                                                              15    9605
NP_006428                                                              15    9605
NP_001078956                                                           15    9605
NP_001165883                                                           15    9605
NP_000393                                                              15    9605
NP_004398                                                              15    9605
NP_689738                                                              15    9605
NP_001103373                                                           15    9605
NP_620409                                                              15    9605
NP_116203                                                              15    9605
NP_001161689                                                           15    9605
NP_001161693                                                           15    9605
XP_005274714                                                           15    9605
XP_006723106                                                           15    9605
XP_006723105                                                           15    9605
XP_006722072                                                           15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_005254026                                                           15    9605
XP_005254025                                                           15    9605
XP_005250571                                                           15    9605
XP_005250570                                                           15    9605
XP_006712394                                                           15    9605
XP_005246404                                                           15    9605
XP_006710998                                                           15    9605
XP_006710377                                                           15    9605
NP_604393                                                              15    9605
NP_001073380                                                           15    9605
NP_065930                                                              15    9605
NP_061741                                                              15    9605
NP_114443                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ADSTLSEEV 9
            ADSTLSEE+
Sbjct: 2032 ADSTLSEEM 2040
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ADSTLSEEV 9
            ADSTLSEE+
Sbjct: 2032 ADSTLSEEM 2040
>NP_065961
          Length = 1934

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ADSTLSEE 8
            ADST+SEE
Sbjct: 1416 ADSTVSEE 1423
>NP_001158137
          Length = 1950

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ADSTLSEE 8
            ADST+SEE
Sbjct: 1416 ADSTVSEE 1423
>XP_006716135
          Length = 718

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ADSTLSEE 8
           ADST+SEE
Sbjct: 200 ADSTVSEE 207
>XP_006716134
          Length = 1847

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ADSTLSEE 8
            ADST+SEE
Sbjct: 1313 ADSTVSEE 1320
>NP_001161710
          Length = 1058

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 524 DSSISEEV 531
>NP_001161709
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 545 DSSISEEV 552
>NP_001161708
          Length = 1161

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 524 DSSISEEV 531
>NP_009298
          Length = 1182

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 545 DSSISEEV 552
>NP_005149
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 530 DSSISEEV 537
>NP_001161711
          Length = 1043

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 509 DSSISEEV 516
>XP_005245145
          Length = 1146

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 509 DSSISEEV 516
>NP_001129472
          Length = 1064

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DSTLSEEV 9
           DS++SEEV
Sbjct: 530 DSSISEEV 537
>NP_055524
          Length = 3546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DSTLSEE 8
            DSTL+EE
Sbjct: 3458 DSTLAEE 3464
>XP_006712395
          Length = 599

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ADSTLSEE 8
           ADS+LSE+
Sbjct: 497 ADSSLSED 504
>NP_786924
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSTLSEEV 9
           DSTL E+V
Sbjct: 233 DSTLKEDV 240
>NP_001810
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADSTLSEEV 9
           +DS +SEEV
Sbjct: 144 SDSQVSEEV 152
>NP_001180
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADSTLSEE 8
           +DS LSEE
Sbjct: 93  SDSALSEE 100
>NP_001258973
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 344 DSTLSE 349
>NP_001258989
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 374 DSTLSE 379
>NP_003152
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 397 DSTLSE 402
>NP_001258972
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 397 DSTLSE 402
>NP_001258971
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 374 DSTLSE 379
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STLSEEV 9
            STL+EEV
Sbjct: 2140 STLAEEV 2146
>NP_006428
          Length = 1724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLSEEV 9
           STLS+EV
Sbjct: 257 STLSQEV 263
>NP_001078956
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DSTLSEE 8
          D+T+SEE
Sbjct: 54 DNTISEE 60
>NP_001165883
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DSTLSEEV 9
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>NP_000393
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADSTLSEEV 9
          ADS ++E+V
Sbjct: 27 ADSVMAEQV 35
>NP_004398
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADSTLSEE 8
          +DST SEE
Sbjct: 67 SDSTQSEE 74
>NP_689738
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADSTLSE 7
           ADS+LSE
Sbjct: 496 ADSSLSE 502
>NP_001103373
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADSTLSEEV 9
           A+STL E+V
Sbjct: 198 ANSTLREQV 206
>NP_620409
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DSTLSEEV 9
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>NP_116203
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADSTLSEEV 9
           A+STL E+V
Sbjct: 198 ANSTLREQV 206
>NP_001161689
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADSTLSE 7
           ADS+LSE
Sbjct: 496 ADSSLSE 502
>NP_001161693
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADSTLSE 7
           ADS+LSE
Sbjct: 496 ADSSLSE 502
>XP_005274714
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ADSTLSEEV 9
          ADS ++E+V
Sbjct: 27 ADSVMAEQV 35
>XP_006723106
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 681 DSTLSE 686
>XP_006723105
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 681 DSTLSE 686
>XP_006722072
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 194 DSTLSE 199
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STLSEEV 9
            STL+EEV
Sbjct: 2054 STLAEEV 2060
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STLSEEV 9
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STLSEEV 9
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STLSEEV 9
            STL+EEV
Sbjct: 2135 STLAEEV 2141
>XP_005254026
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADSTLSEEV 9
           A+STL E+V
Sbjct: 198 ANSTLREQV 206
>XP_005254025
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADSTLSEEV 9
           A+STL E+V
Sbjct: 198 ANSTLREQV 206
>XP_005250571
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 267 DSTLSE 272
>XP_005250570
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 348 DSTLSE 353
>XP_006712394
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADSTLSE 7
           ADS+LSE
Sbjct: 497 ADSSLSE 503
>XP_005246404
          Length = 1821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ADSTLSE 7
           ADS+LSE
Sbjct: 497 ADSSLSE 503
>XP_006710998
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DSTLSEEV 9
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>XP_006710377
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DSTLSEE 8
          D+T+SEE
Sbjct: 54 DNTISEE 60
>NP_604393
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 647 DSTLSE 652
>NP_001073380
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADSTLSEE 8
          +DST SEE
Sbjct: 51 SDSTQSEE 58
>NP_065930
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSTLSE 7
           DSTLSE
Sbjct: 399 DSTLSE 404
>NP_061741
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADSTLSEE 8
           AD+ LSEE
Sbjct: 776 ADTLLSEE 783
>NP_114443
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADSTLSEE 8
           AD+ LSEE
Sbjct: 776 ADTLLSEE 783
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283    0.104    0.227 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 510,910
Number of extensions: 1193
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package