Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     665
NP_001244947                                                           18    1482
NP_758962                                                              18    1482
NP_001244946                                                           18    1482
NP_690863                                                              18    1482
XP_005276448                                                           18    1935
XP_005253328                                                           18    1935
XP_005275753                                                           18    1935
NP_000231                                                              17    3301
NP_055726                                                              17    3301
NP_057097                                                              17    3301
NP_000889                                                              17    3301
XP_005272665                                                           17    3301
XP_005272664                                                           17    3301
XP_006720621                                                           17    3301
XP_006720620                                                           17    3301
XP_006720619                                                           17    3301
XP_006720618                                                           17    3301
NP_001012331                                                           17    4312
NP_002520                                                              17    4312
NP_001007793                                                           17    4312
NP_733786                                                              17    4312
XP_005250066                                                           17    4312
XP_005250063                                                           17    4312
XP_005250061                                                           17    4312
XP_006716084                                                           17    4312
XP_005250060                                                           17    4312
XP_005250059                                                           17    4312
NP_001070973                                                           17    4312
NP_001070974                                                           17    4312
NP_001070972                                                           17    4312
NP_543139                                                              17    4312
NP_004798                                                              16    7355
NP_758953                                                              16    7355
NP_004812                                                              16    7355
NP_002310                                                              16    7355
XP_005250404                                                           16    7355
XP_005250403                                                           16    7355
XP_005268588                                                           16    7355
NP_005915                                                              15    9605
NP_997401                                                              15    9605
NP_002721                                                              15    9605
NP_004086                                                              15    9605
NP_002070                                                              15    9605
NP_060083                                                              15    9605
NP_005387                                                              15    9605
NP_036467                                                              15    9605
NP_001008409                                                           15    9605
NP_891993                                                              15    9605
NP_002722                                                              15    9605
NP_001229788                                                           15    9605
NP_001229790                                                           15    9605
NP_001229786                                                           15    9605
NP_001229787                                                           15    9605
NP_001229789                                                           15    9605
NP_001229791                                                           15    9605
XP_006723782                                                           15    9605
XP_005260041                                                           15    9605
XP_005272534                                                           15    9605
XP_005272533                                                           15    9605
XP_005272532                                                           15    9605
XP_005271080                                                           15    9605
XP_005271079                                                           15    9605
XP_005271078                                                           15    9605
XP_005271077                                                           15    9605
XP_005271076                                                           15    9605
XP_005271075                                                           15    9605
XP_005271074                                                           15    9605
XP_005271073                                                           15    9605
XP_005271072                                                           15    9605
XP_006710821                                                           15    9605
NP_001139669                                                           15    9605
NP_002723                                                              15    9605
NP_001139014                                                           15    9605
NP_997461                                                              15    9605
NP_001092142                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ADKRVGGR 8
           ADKRVGG+
Sbjct: 516 ADKRVGGK 523
>NP_001244947
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_758962
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_001244946
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_690863
          Length = 567

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ADKRVGGR 8
          AD R+GGR
Sbjct: 90 ADNRIGGR 97
>XP_005276448
          Length = 215

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DKRVGGRT 9
          +KRVGGR+
Sbjct: 50 EKRVGGRS 57
>XP_005253328
          Length = 215

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DKRVGGRT 9
          +KRVGGR+
Sbjct: 50 EKRVGGRS 57
>XP_005275753
          Length = 215

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  DKRVGGRT 9
          +KRVGGR+
Sbjct: 50 EKRVGGRS 57
>NP_000231
          Length = 527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ADKRVGGRT 9
          A  RVGGRT
Sbjct: 44 ARDRVGGRT 52
>NP_055726
          Length = 961

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           A+KR GG+T
Sbjct: 757 AEKRKGGQT 765
>NP_057097
          Length = 327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           +DK +GGR+
Sbjct: 140 SDKTIGGRS 148
>NP_000889
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ADKRVGGRT 9
          A  RVGGRT
Sbjct: 35 ARDRVGGRT 43
>XP_005272665
          Length = 504

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ADKRVGGRT 9
          A  RVGGRT
Sbjct: 19 ARDRVGGRT 27
>XP_005272664
          Length = 504

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ADKRVGGRT 9
          A  RVGGRT
Sbjct: 19 ARDRVGGRT 27
>XP_006720621
          Length = 261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           +DK +GGR+
Sbjct: 140 SDKTIGGRS 148
>XP_006720620
          Length = 261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           +DK +GGR+
Sbjct: 140 SDKTIGGRS 148
>XP_006720619
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           +DK +GGR+
Sbjct: 140 SDKTIGGRS 148
>XP_006720618
          Length = 327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           +DK +GGR+
Sbjct: 140 SDKTIGGRS 148
>NP_001012331
          Length = 790

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 676 RVGGRT 681
>NP_002520
          Length = 796

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 682 RVGGRT 687
>NP_001007793
          Length = 760

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 646 RVGGRT 651
>NP_733786
          Length = 113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  KRVGGR 8
          KRVGGR
Sbjct: 69 KRVGGR 74
>XP_005250066
          Length = 358

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 313 RVGGRT 318
>XP_005250063
          Length = 495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 450 RVGGRT 455
>XP_005250061
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 530 RVGGRT 535
>XP_006716084
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 570 RVGGRT 575
>XP_005250060
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 573 RVGGRT 578
>XP_005250059
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           RVGGRT
Sbjct: 574 RVGGRT 579
>NP_001070973
          Length = 76

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  KRVGGR 8
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_001070974
          Length = 107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  KRVGGR 8
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_001070972
          Length = 87

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  KRVGGR 8
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_543139
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKRVGGR 8
           D RVGGR
Sbjct: 138 DARVGGR 144
>NP_004798
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KRVGGRT 9
          +R GGRT
Sbjct: 4  RRAGGRT 10
>NP_758953
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KRVGGRT 9
          KR+GG+T
Sbjct: 12 KRLGGQT 18
>NP_004812
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKRVGGRT 9
           +KR+ GRT
Sbjct: 195 EKRIKGRT 202
>NP_002310
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           A KRVGG+
Sbjct: 641 AVKRVGGK 648
>XP_005250404
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           A KRVGG+
Sbjct: 579 AVKRVGGK 586
>XP_005250403
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           A KRVGG+
Sbjct: 602 AVKRVGGK 609
>XP_005268588
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKRVGGRT 9
           +KR+ GRT
Sbjct: 194 EKRIKGRT 201
>NP_005915
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           A+KR GG+
Sbjct: 159 AEKRSGGK 166
>NP_997401
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 182 KRVKGRT 188
>NP_002721
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 190 KRVKGRT 196
>NP_004086
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   DKRVGG 7
           DKR GG
Sbjct: 104 DKRAGG 109
>NP_002070
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DKRVGG 7
           +KRVGG
Sbjct: 98  EKRVGG 103
>NP_060083
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ADKRVGGRT 9
           AD+++ G+T
Sbjct: 237 ADRKMAGKT 245
>NP_005387
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ADKRVGGR 8
           A +R+GGR
Sbjct: 181 AGRRLGGR 188
>NP_036467
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           +VGGRT
Sbjct: 905 KVGGRT 910
>NP_001008409
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DKRVGG 7
           +KRVGG
Sbjct: 378 EKRVGG 383
>NP_891993
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 237 KRVKGRT 243
>NP_002722
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 190 KRVKGRT 196
>NP_001229788
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 194 KRVKGRT 200
>NP_001229790
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 160 KRVKGRT 166
>NP_001229786
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 197 KRVKGRT 203
>NP_001229787
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 178 KRVKGRT 184
>NP_001229789
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 196 KRVKGRT 202
>NP_001229791
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 177 KRVKGRT 183
>XP_006723782
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DKRVGG 7
           +KRVGG
Sbjct: 375 EKRVGG 380
>XP_005260041
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 266 KRVKGRT 272
>XP_005272534
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           +VGGRT
Sbjct: 878 KVGGRT 883
>XP_005272533
          Length = 1096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           +VGGRT
Sbjct: 903 KVGGRT 908
>XP_005272532
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGGRT 9
           +VGGRT
Sbjct: 907 KVGGRT 912
>XP_005271080
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 178 KRVKGRT 184
>XP_005271079
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 196 KRVKGRT 202
>XP_005271078
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 237 KRVKGRT 243
>XP_005271077
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 237 KRVKGRT 243
>XP_005271076
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 177 KRVKGRT 183
>XP_005271075
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 185 KRVKGRT 191
>XP_005271074
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 186 KRVKGRT 192
>XP_005271073
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 188 KRVKGRT 194
>XP_005271072
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 189 KRVKGRT 195
>XP_006710821
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 193 KRVKGRT 199
>NP_001139669
          Length = 7081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DKRVGGRT 9
            ++R+GG+T
Sbjct: 5449 EERLGGKT 5456
>NP_002723
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 190 KRVKGRT 196
>NP_001139014
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 KRVGGR 8
         +RVGGR
Sbjct: 2 RRVGGR 7
>NP_997461
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KRVGGRT 9
           KRV GRT
Sbjct: 190 KRVKGRT 196
>NP_001092142
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   DKRVGGR 8
           D R+GG+
Sbjct: 421 DNRIGGK 427
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.136    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 628,746
Number of extensions: 1142
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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