Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     299
XP_005262424                                                           20     299
NP_115543                                                              16    5631
NP_001243496                                                           16    5631
NP_001261                                                              16    5631
NP_001186074                                                           16    5631
NP_001186072                                                           16    5631
NP_001073278                                                           16    5631
XP_006721041                                                           16    5631
XP_006721040                                                           16    5631
XP_005255739                                                           16    5631
XP_005271924                                                           16    5631
XP_005271923                                                           16    5631
NP_597722                                                              16    7355
NP_001273967                                                           16    7355
NP_001273965                                                           16    7355
NP_835260                                                              16    7355
XP_006717041                                                           16    7355
XP_006714523                                                           16    7355
XP_005248329                                                           16    7355
XP_005248328                                                           16    7355
XP_006714522                                                           16    7355
XP_006714521                                                           16    7355
XP_006714520                                                           16    7355
XP_005248327                                                           16    7355
XP_005248326                                                           16    7355
XP_006714519                                                           16    7355
XP_005247497                                                           16    7355
NP_001078889                                                           16    7355
NP_036456                                                              15    9605
NP_078966                                                              15    9605
NP_998821                                                              15    9605
NP_001137325                                                           15    9605
XP_006724409                                                           15    9605
XP_005261851                                                           15    9605
XP_005261850                                                           15    9605
XP_006718815                                                           15    9605
XP_006716681                                                           15    9605
NP_055601                                                              15    9605
NP_001034201                                                           15    9605
NP_004308                                                              15    9605
NP_001138678                                                           15    9605
>NP_722576
          Length = 3080

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ADETASKYE 9
            ADETASKY+
Sbjct: 2388 ADETASKYK 2396
>XP_005262424
          Length = 2875

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ADETASKYE 9
            ADETASKY+
Sbjct: 2183 ADETASKYK 2191
>NP_115543
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           A+E AS YE
Sbjct: 581 AEELASSYE 589
>NP_001243496
          Length = 231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ADETASKY 8
           ADE  SKY
Sbjct: 198 ADEALSKY 205
>NP_001261
          Length = 1710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET S YE
Sbjct: 176 DETESDYE 183
>NP_001186074
          Length = 716

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ADETASKYE 9
           A++TA++YE
Sbjct: 518 ANDTANEYE 526
>NP_001186072
          Length = 971

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ADETASKYE 9
           A++TA++YE
Sbjct: 773 ANDTANEYE 781
>NP_001073278
          Length = 938

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ADETASKYE 9
           A++TA++YE
Sbjct: 740 ANDTANEYE 748
>XP_006721041
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           A+E AS YE
Sbjct: 448 AEELASSYE 456
>XP_006721040
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           A+E AS YE
Sbjct: 429 AEELASSYE 437
>XP_005255739
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           A+E AS YE
Sbjct: 591 AEELASSYE 599
>XP_005271924
          Length = 1710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET S YE
Sbjct: 176 DETESDYE 183
>XP_005271923
          Length = 1798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET S YE
Sbjct: 176 DETESDYE 183
>NP_597722
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET  +YE
Sbjct: 132 DETVEEYE 139
>NP_001273967
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET  +YE
Sbjct: 132 DETVEEYE 139
>NP_001273965
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET  +YE
Sbjct: 132 DETVEEYE 139
>NP_835260
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1741 DETLNQYE 1748
>XP_006717041
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DETASKYE 9
           DET  +YE
Sbjct: 132 DETVEEYE 139
>XP_006714523
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1410 DETLNQYE 1417
>XP_005248329
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1567 DETLNQYE 1574
>XP_005248328
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1567 DETLNQYE 1574
>XP_006714522
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1587 DETLNQYE 1594
>XP_006714521
          Length = 2781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1649 DETLNQYE 1656
>XP_006714520
          Length = 2802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1670 DETLNQYE 1677
>XP_005248327
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1741 DETLNQYE 1748
>XP_005248326
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1741 DETLNQYE 1748
>XP_006714519
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            DET ++YE
Sbjct: 1741 DETLNQYE 1748
>XP_005247497
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETASKYE 9
          ET++KYE
Sbjct: 71 ETSNKYE 77
>NP_001078889
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETASKYE 9
          ET++KYE
Sbjct: 83 ETSNKYE 89
>NP_036456
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DETASKYE 9
           D+T S+YE
Sbjct: 325 DDTNSEYE 332
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ADETASK 7
           AD TASK
Sbjct: 197 ADSTASK 203
>NP_998821
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           AD+  +KYE
Sbjct: 178 ADDLRAKYE 186
>NP_001137325
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  DETASKY 8
          DET  KY
Sbjct: 8  DETGGKY 14
>XP_006724409
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            +ETASK E
Sbjct: 1704 EETASKAE 1711
>XP_005261851
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            +ETASK E
Sbjct: 1704 EETASKAE 1711
>XP_005261850
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            +ETASK E
Sbjct: 1704 EETASKAE 1711
>XP_006718815
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ETASKYE 9
           +TASKY+
Sbjct: 336 DTASKYK 342
>XP_006716681
          Length = 1867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    DETASKYE 9
            DET   YE
Sbjct: 1528 DETVESYE 1535
>NP_055601
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    ETASKYE 9
            +TASKY+
Sbjct: 1342 DTASKYK 1348
>NP_001034201
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    DETASKYE 9
            DET   YE
Sbjct: 1518 DETVESYE 1525
>NP_004308
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADETASKYE 9
           AD+ ASK E
Sbjct: 215 ADQLASKLE 223
>NP_001138678
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DETASKYE 9
            +ETASK E
Sbjct: 1704 EETASKAE 1711
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.284    0.103    0.246 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,928
Number of extensions: 823
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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