Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           20     390
NP_001138386                                                           20     390
NP_000132                                                              20     390
NP_075259                                                              20     390
NP_001138385                                                           20     390
XP_006717776                                                           20     390
XP_006717773                                                           20     390
XP_006717772                                                           20     390
XP_006717771                                                           20     390
NP_000381                                                              17    4312
XP_006726431                                                           17    4312
XP_006724678                                                           17    4312
XP_006711778                                                           17    4312
NP_055722                                                              16    5631
NP_598001                                                              16    5631
NP_001177875                                                           16    7355
NP_001010847                                                           16    7355
NP_958928                                                              16    7355
NP_061944                                                              16    7355
NP_001157929                                                           16    7355
XP_005260653                                                           16    7355
XP_005260652                                                           16    7355
XP_005260651                                                           16    7355
XP_005260650                                                           16    7355
XP_005260649                                                           16    7355
XP_005260648                                                           16    7355
XP_005260647                                                           16    7355
XP_005260646                                                           16    7355
XP_005260644                                                           16    7355
XP_005256694                                                           16    7355
XP_006716293                                                           16    7355
XP_006714949                                                           16    7355
XP_006714945                                                           16    7355
XP_006714944                                                           16    7355
XP_006714943                                                           16    7355
XP_006714942                                                           16    7355
XP_006714941                                                           16    7355
XP_006714940                                                           16    7355
XP_006714939                                                           16    7355
XP_006714938                                                           16    7355
XP_006710399                                                           16    7355
NP_006228                                                              16    7355
NP_003648                                                              16    7355
NP_000446                                                              15    9605
NP_689829                                                              15    9605
NP_004765                                                              15    9605
NP_001034704                                                           15    9605
NP_003451                                                              15    9605
NP_001180559                                                           15    9605
NP_001258866                                                           15    9605
NP_060379                                                              15    9605
NP_001277033                                                           15    9605
NP_997465                                                              15    9605
NP_055445                                                              15    9605
NP_001265642                                                           15    9605
NP_003576                                                              15    9605
NP_001230589                                                           15    9605
XP_006725125                                                           15    9605
XP_005257522                                                           15    9605
XP_006721425                                                           15    9605
XP_006721424                                                           15    9605
XP_005255619                                                           15    9605
XP_005255053                                                           15    9605
NP_001004328                                                           15    9605
>NP_001138389
          Length = 705

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 106 ACTASRTVD 114
>NP_001138386
          Length = 709

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 106 ACTASRTVD 114
>NP_000132
          Length = 821

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 106 ACTASRTVD 114
>NP_075259
          Length = 822

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 106 ACTASRTVD 114
>NP_001138385
          Length = 769

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 106 ACTASRTVD 114
>XP_006717776
          Length = 806

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 125 ACTASRTVD 133
>XP_006717773
          Length = 807

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 125 ACTASRTVD 133
>XP_006717772
          Length = 838

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 125 ACTASRTVD 133
>XP_006717771
          Length = 839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ACTASSTVD 9
           ACTAS TVD
Sbjct: 125 ACTASRTVD 133
>NP_000381
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TASSTVD 9
           TASST+D
Sbjct: 347 TASSTID 353
>XP_006726431
          Length = 196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CTA STV
Sbjct: 172 CTAQSTV 178
>XP_006724678
          Length = 632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TASSTVD 9
           TASST+D
Sbjct: 326 TASSTID 332
>XP_006711778
          Length = 196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CTA STV
Sbjct: 172 CTAQSTV 178
>NP_055722
          Length = 1578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           C ASST D
Sbjct: 576 CGASSTTD 583
>NP_598001
          Length = 302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ACTASS 6
           ACTASS
Sbjct: 297 ACTASS 302
>NP_001177875
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 399 SCTSSST 405
>NP_001010847
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  ACTASSTVD 9
          ACT   TVD
Sbjct: 33 ACTDPHTVD 41
>NP_958928
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT SST D
Sbjct: 185 CTFSSTKD 192
>NP_061944
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ACTASSTV 8
           +C++SSTV
Sbjct: 324 SCSSSSTV 331
>NP_001157929
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTRSSTI 131
>XP_005260653
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 447 CTEQATVD 454
>XP_005260652
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 478 CTEQATVD 485
>XP_005260651
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 492 CTEQATVD 499
>XP_005260650
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 511 CTEQATVD 518
>XP_005260649
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 531 CTEQATVD 538
>XP_005260648
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 534 CTEQATVD 541
>XP_005260647
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 548 CTEQATVD 555
>XP_005260646
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 556 CTEQATVD 563
>XP_005260644
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 570 CTEQATVD 577
>XP_005256694
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT SST D
Sbjct: 185 CTFSSTKD 192
>XP_006716293
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTRSSTI 131
>XP_006714949
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 399 SCTSSST 405
>XP_006714945
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 399 SCTSSST 405
>XP_006714944
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ACTASST 7
          +CT+SST
Sbjct: 83 SCTSSST 89
>XP_006714943
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 286 SCTSSST 292
>XP_006714942
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 286 SCTSSST 292
>XP_006714941
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 286 SCTSSST 292
>XP_006714940
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 286 SCTSSST 292
>XP_006714939
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 286 SCTSSST 292
>XP_006714938
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ACTASST 7
           +CT+SST
Sbjct: 399 SCTSSST 405
>XP_006710399
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  ACTASSTVD 9
          ACT   TVD
Sbjct: 33 ACTDPHTVD 41
>NP_006228
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  CTASSTV 8
          CT++STV
Sbjct: 90 CTSTSTV 96
>NP_003648
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CT  +TVD
Sbjct: 525 CTEQATVD 532
>NP_000446
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ACTASSTV 8
           AC+ASS +
Sbjct: 417 ACSASSKI 424
>NP_689829
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  CTASSTVD 9
          CTASS ++
Sbjct: 80 CTASSNLN 87
>NP_004765
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ACTASST 7
            +CTASS+
Sbjct: 1265 SCTASSS 1271
>NP_001034704
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTHSSTI 131
>NP_003451
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASSTVD 9
           C A+ST+D
Sbjct: 545 CWATSTMD 552
>NP_001180559
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTHSSTI 131
>NP_001258866
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTASSTVD 9
          CTA +T D
Sbjct: 3  CTAFATAD 10
>NP_060379
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CTA +T D
Sbjct: 173 CTAFATAD 180
>NP_001277033
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASSTVD 9
           C A+ST+D
Sbjct: 536 CWATSTMD 543
>NP_997465
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CTASST 7
          CT+SST
Sbjct: 46 CTSSST 51
>NP_055445
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TASSTVD 9
           TASST D
Sbjct: 838 TASSTAD 844
>NP_001265642
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTHSSTI 131
>NP_003576
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CTA  T+D
Sbjct: 124 CTALGTLD 131
>NP_001230589
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   CTASSTVD 9
           CTA  T D
Sbjct: 96  CTACETTD 103
>XP_006725125
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTHSSTI 131
>XP_005257522
          Length = 1409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ACTASST 7
            +CTASS+
Sbjct: 1093 SCTASSS 1099
>XP_006721425
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CTA  T+D
Sbjct: 124 CTALGTLD 131
>XP_006721424
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASSTVD 9
           CTA  T+D
Sbjct: 124 CTALGTLD 131
>XP_005255619
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASSTVD 9
           C A+ST+D
Sbjct: 634 CWATSTMD 641
>XP_005255053
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TASSTVD 9
           TASST D
Sbjct: 838 TASSTAD 844
>NP_001004328
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASSTV 8
           CT SST+
Sbjct: 125 CTHSSTI 131
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.104    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 390,061
Number of extensions: 580
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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