Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              20     299
XP_005251512                                                           20     299
NP_003593                                                              17    3301
NP_001268233                                                           17    3301
NP_055462                                                              17    3301
NP_001171928                                                           17    3301
NP_001128683                                                           17    3301
NP_001171927                                                           17    3301
XP_006725284                                                           17    3301
XP_006725283                                                           17    3301
XP_006725282                                                           17    3301
XP_006725281                                                           17    3301
XP_006725280                                                           17    3301
XP_006725279                                                           17    3301
XP_006725278                                                           17    3301
XP_005255766                                                           17    3301
XP_006721049                                                           17    3301
XP_005255765                                                           17    3301
XP_005255764                                                           17    3301
XP_005255763                                                           17    3301
XP_005255762                                                           17    3301
XP_005255761                                                           17    3301
XP_006716216                                                           17    3301
XP_005250700                                                           17    3301
XP_006716215                                                           17    3301
NP_057484                                                              16    5631
NP_443179                                                              16    5631
NP_001171922                                                           16    5631
XP_005266703                                                           16    5631
XP_006719914                                                           16    5631
XP_005266530                                                           16    5631
XP_006719913                                                           16    5631
XP_006719912                                                           16    5631
XP_006719911                                                           16    5631
XP_006719910                                                           16    5631
XP_006719909                                                           16    5631
NP_112567                                                              16    5631
NP_060697                                                              16    7355
XP_006714316                                                           16    7355
NP_005209                                                              15    9605
NP_001137499                                                           15    9605
NP_055249                                                              15    9605
NP_001137500                                                           15    9605
NP_001137498                                                           15    9605
NP_005679                                                              15    9605
NP_001018881                                                           15    9605
NP_060101                                                              15    9605
XP_006717120                                                           15    9605
XP_006717119                                                           15    9605
XP_005266123                                                           15    9605
XP_005247116                                                           15    9605
XP_005247115                                                           15    9605
>NP_004963
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ACLMMTEME 9
          ACL MTEME
Sbjct: 4  ACLTMTEME 12
>XP_005251512
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ACLMMTEME 9
          ACL MTEME
Sbjct: 4  ACLTMTEME 12
>NP_003593
          Length = 327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 262 ACLLLTEYQ 270
>NP_001268233
          Length = 297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 232 ACLLLTEYQ 240
>NP_055462
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1354 CLMMTDL 1360
>NP_001171928
          Length = 1739

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1351 CLMMTDL 1357
>NP_001128683
          Length = 322

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 257 ACLLLTEYQ 265
>NP_001171927
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1354 CLMMTDL 1360
>XP_006725284
          Length = 1564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1176 CLMMTDL 1182
>XP_006725283
          Length = 1600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1212 CLMMTDL 1218
>XP_006725282
          Length = 1613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1225 CLMMTDL 1231
>XP_006725281
          Length = 1733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1345 CLMMTDL 1351
>XP_006725280
          Length = 1741

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1353 CLMMTDL 1359
>XP_006725279
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_006725278
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_005255766
          Length = 1564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1176 CLMMTDL 1182
>XP_006721049
          Length = 1600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1212 CLMMTDL 1218
>XP_005255765
          Length = 1613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1225 CLMMTDL 1231
>XP_005255764
          Length = 1733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1345 CLMMTDL 1351
>XP_005255763
          Length = 1741

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1353 CLMMTDL 1359
>XP_005255762
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_005255761
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    CLMMTEM 8
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_006716216
          Length = 282

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 217 ACLLLTEYQ 225
>XP_005250700
          Length = 287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 222 ACLLLTEYQ 230
>XP_006716215
          Length = 322

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ACLMMTEME 9
           ACL++TE +
Sbjct: 257 ACLLLTEYQ 265
>NP_057484
          Length = 129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LMMTEME 9
           L+MTEME
Sbjct: 97  LIMTEME 103
>NP_443179
          Length = 2170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    CLMMTEME 9
            CL++T+M+
Sbjct: 2075 CLLVTDMQ 2082
>NP_001171922
          Length = 1619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 59 CLLMTE 64
>XP_005266703
          Length = 1501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    CLMMTEME 9
            CL++T+M+
Sbjct: 1406 CLLVTDMQ 1413
>XP_006719914
          Length = 1639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_005266530
          Length = 1643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719913
          Length = 1650

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719912
          Length = 1672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 59 CLLMTE 64
>XP_006719911
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719910
          Length = 1692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719909
          Length = 1692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 79 CLLMTE 84
>NP_112567
          Length = 1623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CLMMTE 7
          CL+MTE
Sbjct: 59 CLLMTE 64
>NP_060697
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   CLMMTEME 9
           C+++TEM+
Sbjct: 156 CVVLTEMK 163
>XP_006714316
          Length = 977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  CLMMTEME 9
          C+++TEM+
Sbjct: 81 CVVLTEMK 88
>NP_005209
          Length = 68

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  CLMMTEM 8
          CL+++EM
Sbjct: 12 CLLLSEM 18
>NP_001137499
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 284 ACLSLHELE 292
>NP_055249
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 318 ACLSLHELE 326
>NP_001137500
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 318 ACLSLHELE 326
>NP_001137498
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 318 ACLSLHELE 326
>NP_005679
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CLMMTEM 8
           CLM+T++
Sbjct: 185 CLMITQL 191
>NP_001018881
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CLMMTEM 8
           CLM+T++
Sbjct: 185 CLMITQL 191
>NP_060101
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CLMMTEME 9
           CL + EME
Sbjct: 299 CLTLQEME 306
>XP_006717120
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 267 ACLSLHELE 275
>XP_006717119
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 336 ACLSLHELE 344
>XP_005266123
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ACLMMTEME 9
           ACL + E+E
Sbjct: 336 ACLSLHELE 344
>XP_005247116
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CLMMTEM 8
           CLM+T++
Sbjct: 185 CLMITQL 191
>XP_005247115
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CLMMTEM 8
           CLM+T++
Sbjct: 185 CLMITQL 191
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.123    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 524,140
Number of extensions: 727
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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