Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           19     665
NP_000242                                                              19     665
XP_005264389                                                           19     665
NP_001107604                                                           18    1935
XP_005246845                                                           18    1935
XP_006712765                                                           18    1935
XP_006712764                                                           18    1935
XP_005246844                                                           18    1935
XP_006712763                                                           18    1935
XP_006712762                                                           18    1935
XP_006712761                                                           18    1935
NP_665803                                                              17    2528
NP_570853                                                              17    4312
NP_570854                                                              17    4312
NP_000453                                                              17    4312
XP_005268328                                                           17    4312
XP_006720739                                                           17    4312
XP_005268327                                                           17    4312
XP_005268326                                                           17    4312
XP_005268324                                                           17    4312
XP_005268325                                                           17    4312
XP_006720738                                                           17    4312
XP_006720737                                                           17    4312
XP_006720736                                                           17    4312
XP_006714215                                                           17    4312
XP_006714214                                                           17    4312
XP_005262915                                                           17    4312
NP_055806                                                              17    4312
NP_057287                                                              16    5631
NP_077747                                                              16    5631
NP_001035723                                                           16    5631
NP_065996                                                              16    5631
XP_005270064                                                           16    5631
XP_005270062                                                           16    5631
XP_005270061                                                           16    5631
XP_005250066                                                           16    5631
XP_005250064                                                           16    5631
XP_005250063                                                           16    5631
XP_005250062                                                           16    5631
XP_005250061                                                           16    5631
XP_006716084                                                           16    5631
XP_005250060                                                           16    5631
XP_005250059                                                           16    5631
NP_852478                                                              16    7355
NP_055192                                                              16    7355
NP_001123359                                                           16    7355
NP_065757                                                              16    7355
NP_001138917                                                           16    7355
XP_005261074                                                           16    7355
XP_006724099                                                           16    7355
XP_006724098                                                           16    7355
XP_005250326                                                           16    7355
NP_001268232                                                           15    9605
NP_006406                                                              15    9605
NP_001153699                                                           15    9605
NP_079413                                                              15    9605
NP_001166251                                                           15    9605
NP_001166250                                                           15    9605
NP_443111                                                              15    9605
NP_954658                                                              15    9605
XP_006720764                                                           15    9605
XP_006720763                                                           15    9605
XP_006720762                                                           15    9605
XP_005254751                                                           15    9605
XP_006719279                                                           15    9605
XP_005268670                                                           15    9605
XP_006719278                                                           15    9605
XP_005247190                                                           15    9605
XP_006713571                                                           15    9605
NP_001164275                                                           15    9605
NP_001164279                                                           15    9605
>NP_001245210
          Length = 868

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAVKALNLF 9
           AAV+ALNLF
Sbjct: 239 AAVRALNLF 247
>NP_000242
          Length = 934

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAVKALNLF 9
           AAV+ALNLF
Sbjct: 305 AAVRALNLF 313
>XP_005264389
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAVKALNLF 9
           AAV+ALNLF
Sbjct: 305 AAVRALNLF 313
>NP_001107604
          Length = 2694

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2231 AAVEALNVF 2239
>XP_005246845
          Length = 1624

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 1148 AAVEALNVF 1156
>XP_006712765
          Length = 2679

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2203 AAVEALNVF 2211
>XP_006712764
          Length = 2697

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2260 AAVEALNVF 2268
>XP_005246844
          Length = 2707

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2231 AAVEALNVF 2239
>XP_006712763
          Length = 2716

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2260 AAVEALNVF 2268
>XP_006712762
          Length = 2723

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2260 AAVEALNVF 2268
>XP_006712761
          Length = 2736

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+ALN+F
Sbjct: 2260 AAVEALNVF 2268
>NP_665803
          Length = 1025

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AAVKALNLF 9
           AAVKAL+L+
Sbjct: 177 AAVKALSLY 185
>NP_570853
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>NP_570854
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 65 AAIKALELY 73
>NP_000453
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 68 AAIKALELY 76
>XP_005268328
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_006720739
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_005268327
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_005268326
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_005268324
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_005268325
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_006720738
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 45 AAIKALELY 53
>XP_006720737
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 65 AAIKALELY 73
>XP_006720736
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KAL L+
Sbjct: 65 AAIKALELY 73
>XP_006714215
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+A+N+F
Sbjct: 2941 AAVEAVNVF 2949
>XP_006714214
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+A+N+F
Sbjct: 2941 AAVEAVNVF 2949
>XP_005262915
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+A+N+F
Sbjct: 2941 AAVEAVNVF 2949
>NP_055806
          Length = 3526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    AAVKALNLF 9
            AAV+A+N+F
Sbjct: 2923 AAVEAVNVF 2931
>NP_057287
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 446 IKALNIF 452
>NP_077747
          Length = 328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 205 IKALNIF 211
>NP_001035723
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 402 IKALNIF 408
>NP_065996
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AAVKALNLF 9
            AAV A+N+F
Sbjct: 2768 AAVDAVNIF 2776
>XP_005270064
          Length = 1615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AAVKALNLF 9
            AAV A+N+F
Sbjct: 1199 AAVDAVNIF 1207
>XP_005270062
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AAVKALNLF 9
            AAV A+N+F
Sbjct: 2768 AAVDAVNIF 2776
>XP_005270061
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    AAVKALNLF 9
            AAV A+N+F
Sbjct: 2768 AAVDAVNIF 2776
>XP_005250066
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 185 IKALNIF 191
>XP_005250064
          Length = 444

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 321 IKALNIF 327
>XP_005250063
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 322 IKALNIF 328
>XP_005250062
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 445 IKALNIF 451
>XP_005250061
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 402 IKALNIF 408
>XP_006716084
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 442 IKALNIF 448
>XP_005250060
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 445 IKALNIF 451
>XP_005250059
          Length = 619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KALN+F
Sbjct: 446 IKALNIF 452
>NP_852478
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AAVKALNL 8
           AAVK LNL
Sbjct: 576 AAVKDLNL 583
>NP_055192
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KA+NLF
Sbjct: 463 IKAVNLF 469
>NP_001123359
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KA+NLF
Sbjct: 410 IKAVNLF 416
>NP_065757
          Length = 1147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KA+ L+
Sbjct: 32 AAIKAIKLY 40
>NP_001138917
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KA+ L+
Sbjct: 32 AAIKAIKLY 40
>XP_005261074
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KA+ L+
Sbjct: 32 AAIKAIKLY 40
>XP_006724099
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KA+ L+
Sbjct: 32 AAIKAIKLY 40
>XP_006724098
          Length = 1143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAVKALNLF 9
          AA+KA+ L+
Sbjct: 32 AAIKAIKLY 40
>XP_005250326
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKALNLF 9
           +KA+NLF
Sbjct: 317 IKAVNLF 323
>NP_001268232
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAVKALNL 8
           AA++ALN+
Sbjct: 348 AAIEALNI 355
>NP_006406
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAVKALNL 8
           AA++ALN+
Sbjct: 348 AAIEALNI 355
>NP_001153699
          Length = 2330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>NP_079413
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>NP_001166251
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AVKALNL 8
           A+KA+NL
Sbjct: 236 AIKAINL 242
>NP_001166250
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AVKALNL 8
           A+KA+NL
Sbjct: 236 AIKAINL 242
>NP_443111
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 269 ARIKAINTF 277
>NP_954658
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 268 ARIKAINTF 276
>XP_006720764
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>XP_006720763
          Length = 2395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>XP_006720762
          Length = 2397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>XP_005254751
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           AA++ LN F
Sbjct: 183 AAIRVLNCF 191
>XP_006719279
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 269 ARIKAINTF 277
>XP_005268670
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 199 ARIKAINTF 207
>XP_006719278
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 269 ARIKAINTF 277
>XP_005247190
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AVKALNL 8
           A+KA+NL
Sbjct: 175 AIKAINL 181
>XP_006713571
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AVKALNL 8
           A+KA+NL
Sbjct: 218 AIKAINL 224
>NP_001164275
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 269 ARIKAINTF 277
>NP_001164279
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAVKALNLF 9
           A +KA+N F
Sbjct: 269 ARIKAINTF 277
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.135    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 255,062
Number of extensions: 415
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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