Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              18    1482
NP_001008781                                                           17    4312
XP_006718827                                                           17    4312
NP_005631                                                              16    5631
NP_001523                                                              16    5631
XP_005258397                                                           16    5631
XP_005258396                                                           16    5631
XP_006722591                                                           16    5631
XP_006718591                                                           16    5631
XP_006718589                                                           16    5631
XP_006718588                                                           16    5631
XP_006718587                                                           16    5631
XP_006718586                                                           16    5631
NP_065772                                                              16    7355
NP_079164                                                              16    7355
NP_001229371                                                           16    7355
NP_919420                                                              16    7355
NP_001124506                                                           16    7355
XP_006724837                                                           16    7355
XP_005272332                                                           16    7355
XP_006713941                                                           16    7355
XP_006713940                                                           16    7355
XP_005272331                                                           16    7355
NP_003310                                                              15    9605
NP_116218                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001073966                                                           15    9605
NP_073752                                                              15    9605
NP_002245                                                              15    9605
XP_006720709                                                           15    9605
XP_005254660                                                           15    9605
XP_006719717                                                           15    9605
XP_005254027                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
XP_005264356                                                           15    9605
NP_078785                                                              15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_004110
          Length = 993

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AAVEVDVS 8
          AAVEVDVS
Sbjct: 79 AAVEVDVS 86
>NP_001008781
          Length = 4557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAVEVDVSP 9
            AAV+VD  P
Sbjct: 2091 AAVQVDAEP 2099
>XP_006718827
          Length = 3479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           AAV+VD  P
Sbjct: 981 AAVQVDAEP 989
>NP_005631
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVEVDVSP 9
           AAV++++SP
Sbjct: 245 AAVQINLSP 253
>NP_001523
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>XP_005258397
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVEVDVSP 9
           AAV++++SP
Sbjct: 245 AAVQINLSP 253
>XP_005258396
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVEVDVSP 9
           AAV++++SP
Sbjct: 245 AAVQINLSP 253
>XP_006722591
          Length = 827

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVEVDVSP 9
           AAV++++SP
Sbjct: 245 AAVQINLSP 253
>XP_006718591
          Length = 301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>XP_006718589
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>XP_006718588
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>XP_006718587
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>XP_006718586
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           A V+VD+SP
Sbjct: 115 ALVKVDMSP 123
>NP_065772
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AAVEVDVS 8
            AA+E D+S
Sbjct: 1142 AAIEADIS 1149
>NP_079164
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           AAV V VSP
Sbjct: 214 AAVYVSVSP 222
>NP_001229371
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  AVEVDVSP 9
          A+E+D+SP
Sbjct: 23 AMELDLSP 30
>NP_919420
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVEVDVSP 9
           ++EVD+SP
Sbjct: 158 SMEVDLSP 165
>NP_001124506
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVEVDVSP 9
           ++EVD+SP
Sbjct: 158 SMEVDLSP 165
>XP_006724837
          Length = 1533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAVEVDVS 8
           AA+E D+S
Sbjct: 966 AAIEADIS 973
>XP_005272332
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVEVDVSP 9
           ++EVD+SP
Sbjct: 158 SMEVDLSP 165
>XP_006713941
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  AVEVDVSP 9
          ++EVD+SP
Sbjct: 92 SMEVDLSP 99
>XP_006713940
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVEVDVSP 9
           ++EVD+SP
Sbjct: 114 SMEVDLSP 121
>XP_005272331
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVEVDVSP 9
           ++EVD+SP
Sbjct: 158 SMEVDLSP 165
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AVEVDVS 8
            AVE+DVS
Sbjct: 8606 AVELDVS 8612
>NP_116218
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           AAV+V ++P
Sbjct: 139 AAVQVGIAP 147
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AVEVDVS 8
            AVE+DVS
Sbjct: 8731 AVELDVS 8737
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     AVEVDVS 8
             AVE+DVS
Sbjct: 16030 AVELDVS 16036
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     AVEVDVS 8
             AVE+DVS
Sbjct: 15103 AVELDVS 15109
>NP_001073966
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AAVEVDVSP 9
          AA +VD SP
Sbjct: 47 AAGQVDASP 55
>NP_073752
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           +AVEV V P
Sbjct: 533 SAVEVKVEP 541
>NP_002245
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VEVDVSP 9
           +E+DVSP
Sbjct: 712 LELDVSP 718
>XP_006720709
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           +AVEV V P
Sbjct: 262 SAVEVKVEP 270
>XP_005254660
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           +AVEV V P
Sbjct: 533 SAVEVKVEP 541
>XP_006719717
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           AAV+V ++P
Sbjct: 139 AAVQVGIAP 147
>XP_005254027
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAVEVDVSP 9
           AAV+V ++P
Sbjct: 139 AAVQVGIAP 147
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AVEVDVS 8
            AVE+DVS
Sbjct: 4343 AVELDVS 4349
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AVEVDVS 8
            AVE+DVS
Sbjct: 5702 AVELDVS 5708
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     AVEVDVS 8
             AVE+DVS
Sbjct: 15658 AVELDVS 15664
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     AVEVDVS 8
             AVE+DVS
Sbjct: 17164 AVELDVS 17170
>XP_005264356
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VEVDVSP 9
           +E+DVSP
Sbjct: 711 LELDVSP 717
>NP_078785
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAVEVDVSP 9
           AAVE+ V P
Sbjct: 377 AAVELTVGP 385
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     AVEVDVS 8
             AVE+DVS
Sbjct: 17671 AVELDVS 17677
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AVEVDVS 8
            AVE+DVS
Sbjct: 8798 AVELDVS 8804
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.120    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 495,871
Number of extensions: 632
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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