Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              18    1135
NP_009297                                                              18    1135
NP_001243778                                                           17    2528
NP_002682                                                              17    2528
XP_005259065                                                           17    2528
XP_006723311                                                           17    2528
XP_005259064                                                           17    2528
XP_005259063                                                           17    2528
NP_001264044                                                           16    5631
NP_002882                                                              16    5631
NP_722522                                                              16    5631
NP_001139120                                                           16    5631
XP_006720692                                                           16    5631
XP_006720691                                                           16    5631
XP_006720690                                                           16    5631
XP_005254635                                                           16    5631
XP_005268838                                                           16    5631
XP_005268836                                                           16    5631
XP_005268834                                                           16    5631
XP_005268833                                                           16    5631
NP_037376                                                              16    5631
NP_064445                                                              16    7355
NP_001245308                                                           16    7355
NP_003606                                                              16    7355
NP_001245309                                                           16    7355
NP_000504                                                              16    7355
NP_001171487                                                           16    7355
NP_001041646                                                           16    7355
XP_005276782                                                           16    7355
XP_003960138                                                           16    7355
XP_005265658                                                           16    7355
XP_005265657                                                           16    7355
XP_005265656                                                           16    7355
XP_005265655                                                           16    7355
XP_006713484                                                           16    7355
XP_005246752                                                           16    7355
XP_006712705                                                           16    7355
NP_071341                                                              16    7355
NP_001171486                                                           15    9605
NP_057609                                                              15    9605
NP_001164674                                                           15    9605
NP_001164675                                                           15    9605
NP_055969                                                              15    9605
NP_001164673                                                           15    9605
XP_006716842                                                           15    9605
XP_005246753                                                           15    9605
XP_005246751                                                           15    9605
XP_006712706                                                           15    9605
XP_006712704                                                           15    9605
XP_005246750                                                           15    9605
NP_001164672                                                           15    9605
>NP_005148
          Length = 1130

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AATLDFSKL 9
            AAT DFSKL
Sbjct: 1109 AATQDFSKL 1117
>NP_009297
          Length = 1149

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AATLDFSKL 9
            AAT DFSKL
Sbjct: 1128 AATQDFSKL 1136
>NP_001243778
          Length = 1107

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 599 ATLDFSSL 606
>NP_002682
          Length = 1107

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 599 ATLDFSSL 606
>XP_005259065
          Length = 1083

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 599 ATLDFSSL 606
>XP_006723311
          Length = 1109

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 625 ATLDFSSL 632
>XP_005259064
          Length = 1133

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 625 ATLDFSSL 632
>XP_005259063
          Length = 1133

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLDFS L
Sbjct: 625 ATLDFSSL 632
>NP_001264044
          Length = 4516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AATLDFSKL 9
           A TL+F KL
Sbjct: 479 ATTLEFEKL 487
>NP_002882
          Length = 1273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 795 ATLDTSKL 802
>NP_722522
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  ATLDFSKL 9
          ATLD SKL
Sbjct: 11 ATLDTSKL 18
>NP_001139120
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 779 ATLDTSKL 786
>XP_006720692
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 792 ATLDTSKL 799
>XP_006720691
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 779 ATLDTSKL 786
>XP_006720690
          Length = 1245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 779 ATLDTSKL 786
>XP_005254635
          Length = 1280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ATLDFSKL 9
           ATLD SKL
Sbjct: 779 ATLDTSKL 786
>XP_005268838
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLDFSKL 9
           TL+FSKL
Sbjct: 251 TLEFSKL 257
>XP_005268836
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLDFSKL 9
           TL+FSKL
Sbjct: 251 TLEFSKL 257
>XP_005268834
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLDFSKL 9
           TL+FSKL
Sbjct: 280 TLEFSKL 286
>XP_005268833
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLDFSKL 9
           TL+FSKL
Sbjct: 280 TLEFSKL 286
>NP_037376
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLDFSKL 9
           TL+FSKL
Sbjct: 251 TLEFSKL 257
>NP_064445
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AATLDFSKL 9
          AAT+ F KL
Sbjct: 76 AATMKFKKL 84
>NP_001245308
          Length = 1131

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 288 STVDFSKV 295
>NP_003606
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 407 STVDFSKV 414
>NP_001245309
          Length = 1090

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 283 STVDFSKV 290
>NP_000504
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AATLDFSKL 9
          AAT+ F KL
Sbjct: 76 AATMKFKKL 84
>NP_001171487
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 291 STVDFSKV 298
>NP_001041646
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AATLDFSKL 9
          AAT+ F KL
Sbjct: 76 AATMKFKKL 84
>XP_005276782
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AATLDFSKL 9
          AAT+ F KL
Sbjct: 76 AATMKFKKL 84
>XP_003960138
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AATLDFSKL 9
          AAT+ F KL
Sbjct: 76 AATMKFKKL 84
>XP_005265658
          Length = 1095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 288 STVDFSKV 295
>XP_005265657
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 270 STVDFSKV 277
>XP_005265656
          Length = 1118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 275 STVDFSKV 282
>XP_005265655
          Length = 1126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 283 STVDFSKV 290
>XP_006713484
          Length = 1255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 412 STVDFSKV 419
>XP_005246752
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 291 STVDFSKV 298
>XP_006712705
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 348 STVDFSKV 355
>NP_071341
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATLDFSKL 9
           +T+DFSK+
Sbjct: 280 STVDFSKV 287
>NP_001171486
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 280 STVDFSK 286
>NP_057609
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 221 ATLDFKPL 228
>NP_001164674
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 221 ATLDFKPL 228
>NP_001164675
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 221 ATLDFKPL 228
>NP_055969
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AATLDFSKL 9
          +A +DFSK+
Sbjct: 88 SAPVDFSKI 96
>NP_001164673
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 257 ATLDFKPL 264
>XP_006716842
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 221 ATLDFKPL 228
>XP_005246753
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 349 STVDFSK 355
>XP_005246751
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 291 STVDFSK 297
>XP_006712706
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 292 STVDFSK 298
>XP_006712704
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 348 STVDFSK 354
>XP_005246750
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATLDFSK 8
           +T+DFSK
Sbjct: 349 STVDFSK 355
>NP_001164672
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ATLDFSKL 9
           ATLDF  L
Sbjct: 285 ATLDFKPL 292
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.128    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,762
Number of extensions: 402
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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