Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055726                                                              20     509
NP_851320                                                              17    4312
NP_001001924                                                           16    5631
NP_001001925                                                           16    5631
NP_001071087                                                           16    5631
NP_112198                                                              16    5631
NP_001171925                                                           16    5631
XP_005273640                                                           16    5631
XP_005273639                                                           16    5631
XP_005273638                                                           16    5631
XP_005273637                                                           16    5631
XP_005273636                                                           16    5631
XP_005273635                                                           16    5631
XP_005273634                                                           16    5631
XP_005249579                                                           16    5631
NP_001171926                                                           16    5631
NP_002560                                                              16    7355
NP_001276753                                                           16    7355
NP_001276752                                                           16    7355
NP_001004439                                                           16    7355
NP_001274442                                                           16    7355
NP_001193665                                                           16    7355
NP_061327                                                              16    7355
NP_057227                                                              16    7355
NP_001138392                                                           16    7355
NP_079202                                                              16    7355
NP_001274441                                                           16    7355
NP_001138395                                                           16    7355
XP_006723657                                                           16    7355
XP_006723656                                                           16    7355
XP_006723655                                                           16    7355
XP_006723654                                                           16    7355
XP_005254285                                                           16    7355
XP_005250665                                                           16    7355
XP_006716198                                                           16    7355
NP_001138467                                                           16    7355
NP_001193531                                                           15    9605
NP_001277261                                                           15    9605
NP_037518                                                              15    9605
NP_998816                                                              15    9605
NP_001277259                                                           15    9605
NP_036233                                                              15    9605
NP_001188379                                                           15    9605
NP_001188380                                                           15    9605
XP_005271544                                                           15    9605
>NP_055726
          Length = 961

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           A QGQKVGS
Sbjct: 610 AVQGQKVGS 618
>NP_851320
          Length = 440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AQGQKVG 8
          AQGQ++G
Sbjct: 37 AQGQRIG 43
>NP_001001924
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>NP_001001925
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>NP_001071087
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           + +GQK+GS
Sbjct: 216 SGEGQKLGS 224
>NP_112198
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ+VG+
Sbjct: 302 AAGGQRVGA 310
>NP_001171925
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ+VG+
Sbjct: 302 AAGGQRVGA 310
>XP_005273640
          Length = 969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273639
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273638
          Length = 1228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273637
          Length = 1228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273636
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273635
          Length = 1282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005273634
          Length = 1282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GQKVGS 9
           GQKVGS
Sbjct: 402 GQKVGS 407
>XP_005249579
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ+VG+
Sbjct: 302 AAGGQRVGA 310
>NP_001171926
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ+VG+
Sbjct: 302 AAGGQRVGA 310
>NP_002560
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AQGQKV 7
          AQGQKV
Sbjct: 24 AQGQKV 29
>NP_001276753
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AQGQKV 7
          AQGQKV
Sbjct: 24 AQGQKV 29
>NP_001276752
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AQGQKV 7
          AQGQKV
Sbjct: 24 AQGQKV 29
>NP_001004439
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           A +GQ++GS
Sbjct: 470 AMRGQQIGS 478
>NP_001274442
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 222 AALGQEMGS 230
>NP_001193665
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 258 EGQKLGS 264
>NP_061327
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 225 EGQKLGS 231
>NP_057227
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 256 EGQKLGS 262
>NP_001138392
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 327 AALGQEMGS 335
>NP_079202
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 327 AALGQEMGS 335
>NP_001274441
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 196 AALGQEMGS 204
>NP_001138395
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 296 AALGQEMGS 304
>XP_006723657
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 145 EGQKLGS 151
>XP_006723656
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 147 EGQKLGS 153
>XP_006723655
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 147 EGQKLGS 153
>XP_006723654
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+GS
Sbjct: 171 EGQKLGS 177
>XP_005254285
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           A +GQ++GS
Sbjct: 368 AMRGQQIGS 376
>XP_005250665
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 187 AALGQEMGS 195
>XP_006716198
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAQGQKVGS 9
           AA GQ++GS
Sbjct: 221 AALGQEMGS 229
>NP_001138467
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AQGQKVG 8
          A+G+KVG
Sbjct: 38 AEGEKVG 44
>NP_001193531
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AAQGQKVGS 9
          AA G K+GS
Sbjct: 32 AALGMKLGS 40
>NP_001277261
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AAQGQKVG 8
          A QG+K+G
Sbjct: 10 AVQGRKMG 17
>NP_037518
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+G+
Sbjct: 282 EGQKIGT 288
>NP_998816
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QGQKVGS 9
           +GQK+G+
Sbjct: 263 EGQKIGT 269
>NP_001277259
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AAQGQKVGS 9
          A +GQ VG+
Sbjct: 57 ATEGQSVGT 65

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAQGQKVGS 9
           A +GQ VG+
Sbjct: 214 ATEGQSVGT 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAQGQKVGS 9
           A +GQ VG+
Sbjct: 281 ATEGQSVGT 289
>NP_036233
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAQGQKVGS 9
          AA+G+ +GS
Sbjct: 50 AAEGKSLGS 58
>NP_001188379
          Length = 128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AAQGQKVG 8
          A QG KVG
Sbjct: 13 AVQGGKVG 20
>NP_001188380
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AAQGQKVG 8
          A QG KVG
Sbjct: 13 AVQGGKVG 20
>XP_005271544
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAQGQKVGS 9
          AA+G+ +GS
Sbjct: 50 AAEGKSLGS 58
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.113    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 547,390
Number of extensions: 1059
Number of successful extensions: 47
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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