Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     299
NP_001120972                                                           20     299
XP_006716052                                                           20     299
XP_006716051                                                           20     299
XP_006721060                                                           17    3301
NP_001164192                                                           17    4312
NP_001164188                                                           17    4312
NP_001164187                                                           17    4312
NP_055382                                                              17    4312
NP_001164186                                                           17    4312
NP_001164189                                                           17    4312
NP_001164185                                                           17    4312
NP_001164190                                                           17    4312
NP_001164191                                                           17    4312
NP_001073996                                                           17    4312
XP_006721412                                                           17    4312
XP_005256317                                                           17    4312
XP_005256316                                                           17    4312
XP_005256315                                                           17    4312
XP_006721411                                                           17    4312
XP_006712602                                                           17    4312
NP_003467                                                              16    5631
NP_000188                                                              16    5631
XP_006720282                                                           16    5631
XP_006720281                                                           16    5631
XP_006720280                                                           16    5631
XP_006720279                                                           16    5631
XP_005267972                                                           16    5631
XP_005267971                                                           16    5631
XP_006720278                                                           16    5631
XP_005267970                                                           16    5631
XP_006718402                                                           16    5631
XP_006717157                                                           16    5631
NP_065766                                                              16    5631
NP_001103132                                                           16    7355
NP_056344                                                              15    9605
NP_940880                                                              15    9605
NP_054868                                                              15    9605
XP_006726692                                                           15    9605
XP_005250342                                                           15    9605
XP_006715519                                                           15    9605
XP_006714166                                                           15    9605
XP_006714164                                                           15    9605
XP_006714163                                                           15    9605
XP_006714162                                                           15    9605
XP_006714161                                                           15    9605
XP_006714160                                                           15    9605
XP_005262823                                                           15    9605
XP_006710063                                                           15    9605
>NP_000236
          Length = 1390

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAIQSEVHC 9
           A IQSEVHC
Sbjct: 152 ADIQSEVHC 160
>NP_001120972
          Length = 1408

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAIQSEVHC 9
           A IQSEVHC
Sbjct: 152 ADIQSEVHC 160
>XP_006716052
          Length = 1409

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAIQSEVHC 9
           A IQSEVHC
Sbjct: 171 ADIQSEVHC 179
>XP_006716051
          Length = 1427

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAIQSEVHC 9
           A IQSEVHC
Sbjct: 171 ADIQSEVHC 179
>XP_006721060
          Length = 693

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+Q E+H
Sbjct: 399 AAVQGEIH 406
>NP_001164192
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 299 AAVQSAVH 306
>NP_001164188
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_001164187
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_055382
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>NP_001164186
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_001164189
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>NP_001164185
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 555 AAVQSAVH 562
>NP_001164190
          Length = 868

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 507 AAVQSAVH 514
>NP_001164191
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 361 AAVQSAVH 368
>NP_001073996
          Length = 2116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQSEVHC 9
            A+Q EV+C
Sbjct: 1705 ALQDEVYC 1712
>XP_006721412
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 462 AAVQSAVH 469
>XP_005256317
          Length = 841

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 480 AAVQSAVH 487
>XP_005256316
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>XP_005256315
          Length = 896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 535 AAVQSAVH 542
>XP_006721411
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIQSEVH 8
           AA+QS VH
Sbjct: 555 AAVQSAVH 562
>XP_006712602
          Length = 2142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQSEVHC 9
            A+Q EV+C
Sbjct: 1731 ALQDEVYC 1738
>NP_003467
          Length = 194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AAIQSEVHC 9
          AA +SE++C
Sbjct: 50 AAHESEIYC 58
>NP_000188
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IQSEVHC 9
           IQS +HC
Sbjct: 150 IQSLIHC 156
>XP_006720282
          Length = 891

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 420 LQSEIYC 426
>XP_006720281
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 466 LQSEIYC 472
>XP_006720280
          Length = 945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 474 LQSEIYC 480
>XP_006720279
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 720 LQSEIYC 726
>XP_005267972
          Length = 1325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_005267971
          Length = 1344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_006720278
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_005267970
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_006718402
          Length = 238

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AAIQSEVHC 9
           AA +SE++C
Sbjct: 94  AAHESEIYC 102
>XP_006717157
          Length = 256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IQSEVHC 9
           IQS +HC
Sbjct: 96  IQSLIHC 102
>NP_065766
          Length = 1364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IQSEVHC 9
           +QSE++C
Sbjct: 893 LQSEIYC 899
>NP_001103132
          Length = 4284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    AIQSEVH 8
            A+QSE+H
Sbjct: 3080 ALQSELH 3086
>NP_056344
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QSEVHC 9
           QSE HC
Sbjct: 359 QSEGHC 364
>NP_940880
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QSEVHC 9
           QSE HC
Sbjct: 331 QSEWHC 336
>NP_054868
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AIQSEVH 8
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006726692
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   AIQSEVH 8
           A+Q E+H
Sbjct: 369 AVQGEIH 375
>XP_005250342
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AIQSEVH 8
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006715519
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QSEVHC 9
           QSE HC
Sbjct: 349 QSEGHC 354
>XP_006714166
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_006714164
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714163
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714162
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 19 SIQSELH 25
>XP_006714160
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_005262823
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIQSEVH 8
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_006710063
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   AIQSEVH 8
           A+Q E+H
Sbjct: 400 AVQGEIH 406
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.121    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 475,360
Number of extensions: 700
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package