Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     229
NP_671714                                                              21     229
XP_006715890                                                           21     229
XP_005250160                                                           21     229
XP_005250159                                                           21     229
NP_005172                                                              18    1135
NP_037484                                                              17    4312
NP_001074445                                                           17    4312
XP_006719566                                                           17    4312
XP_005267010                                                           17    4312
NP_001273485                                                           16    5631
NP_001243326                                                           16    7355
NP_004504                                                              16    7355
NP_001165599                                                           16    7355
NP_757366                                                              16    7355
NP_001032367                                                           16    7355
NP_005307                                                              16    7355
NP_001135779                                                           16    7355
NP_001243329                                                           16    7355
NP_001243327                                                           16    7355
NP_114144                                                              16    7355
XP_005254403                                                           16    7355
XP_005254402                                                           16    7355
XP_005254401                                                           16    7355
XP_005254400                                                           16    7355
XP_005254399                                                           16    7355
XP_006718271                                                           16    7355
NP_004393                                                              15    9605
NP_001269598                                                           15    9605
NP_055446                                                              15    9605
NP_114072                                                              15    9605
NP_001092805                                                           15    9605
NP_055574                                                              15    9605
NP_001128669                                                           15    9605
NP_037408                                                              15    9605
NP_001399                                                              15    9605
XP_005270355                                                           15    9605
XP_006718143                                                           15    9605
XP_005270354                                                           15    9605
XP_005270352                                                           15    9605
XP_005270351                                                           15    9605
XP_006718142                                                           15    9605
XP_006716479                                                           15    9605
XP_005265157                                                           15    9605
XP_005265156                                                           15    9605
XP_006713187                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
NP_835467                                                              15    9605
>NP_005742
          Length = 3907

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAIKQRDGV 9
           AAIKQRDG+
Sbjct: 198 AAIKQRDGI 206
>NP_671714
          Length = 3899

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAIKQRDGV 9
           AAIKQRDG+
Sbjct: 198 AAIKQRDGI 206
>XP_006715890
          Length = 3860

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAIKQRDGV 9
           AAIKQRDG+
Sbjct: 198 AAIKQRDGI 206
>XP_005250160
          Length = 3939

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAIKQRDGV 9
           AAIKQRDG+
Sbjct: 198 AAIKQRDGI 206
>XP_005250159
          Length = 3952

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AAIKQRDGV 9
           AAIKQRDG+
Sbjct: 198 AAIKQRDGI 206
>NP_005172
          Length = 260

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIKQRDGV 9
           A+KQRDG+
Sbjct: 133 ALKQRDGI 140
>NP_037484
          Length = 958

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAIKQRDGV 9
           A I+QRDG+
Sbjct: 605 AFIRQRDGL 613
>NP_001074445
          Length = 958

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAIKQRDGV 9
           A I+QRDG+
Sbjct: 605 AFIRQRDGL 613
>XP_006719566
          Length = 261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           AA+KQR G
Sbjct: 177 AALKQRSG 184
>XP_005267010
          Length = 958

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAIKQRDGV 9
           A I+QRDG+
Sbjct: 605 AFIRQRDGL 613
>NP_001273485
          Length = 438

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AIKQRDGV 9
           ++KQ+DG+
Sbjct: 278 SLKQKDGI 285
>NP_001243326
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           +A+KQ DG
Sbjct: 402 SAVKQADG 409
>NP_004504
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAIKQRDGV 9
           A +KQ DG+
Sbjct: 402 ATLKQLDGI 410
>NP_001165599
          Length = 1331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AAIKQRDGV 9
            A +KQ DG+
Sbjct: 1103 ATLKQLDGI 1111
>NP_757366
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AAIKQRDGV 9
            A +KQ DG+
Sbjct: 1103 ATLKQLDGI 1111
>NP_001032367
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           +A+KQ DG
Sbjct: 402 SAVKQADG 409
>NP_005307
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AIKQRDGV 9
          A+K+RD V
Sbjct: 85 AVKERDAV 92
>NP_001135779
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AIKQRDGV 9
          A+K+RD V
Sbjct: 85 AVKERDAV 92
>NP_001243329
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           +A+KQ DG
Sbjct: 331 SAVKQADG 338
>NP_001243327
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           +A+KQ DG
Sbjct: 363 SAVKQADG 370
>NP_114144
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           +A+KQ DG
Sbjct: 436 SAVKQADG 443
>XP_005254403
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAIKQRDGV 9
           A +KQ DG+
Sbjct: 402 ATLKQLDGI 410
>XP_005254402
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAIKQRDGV 9
           A +KQ DG+
Sbjct: 493 ATLKQLDGI 501
>XP_005254401
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AAIKQRDGV 9
           A +KQ DG+
Sbjct: 493 ATLKQLDGI 501
>XP_005254400
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AAIKQRDGV 9
            A +KQ DG+
Sbjct: 1150 ATLKQLDGI 1158
>XP_005254399
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AAIKQRDGV 9
            A +KQ DG+
Sbjct: 1150 ATLKQLDGI 1158
>XP_006718271
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AIKQRDGV 9
          A+K+RD V
Sbjct: 85 AVKERDAV 92
>NP_004393
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKQRDG 8
           AIK++DG
Sbjct: 275 AIKEQDG 281
>NP_001269598
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKQRDG 8
           AIK++DG
Sbjct: 299 AIKEQDG 305
>NP_055446
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 937 AVKMRNGV 944
>NP_114072
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAIKQRDG 8
           + IKQ+DG
Sbjct: 512 SVIKQQDG 519
>NP_001092805
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIKQRDG 8
          A+KQ DG
Sbjct: 91 AVKQSDG 97
>NP_055574
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIKQRDG 8
          A+KQ DG
Sbjct: 91 AVKQSDG 97
>NP_001128669
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKQRDG 8
           IKQ+DG
Sbjct: 427 IKQKDG 432
>NP_037408
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AAIKQRD 7
           AA++QRD
Sbjct: 357 AAVQQRD 363
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIKQRDGV 9
            A K+RDG+
Sbjct: 1396 ATKERDGL 1403
>XP_005270355
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 800 AVKMRNGV 807
>XP_006718143
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 831 AVKMRNGV 838
>XP_005270354
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 846 AVKMRNGV 853
>XP_005270352
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 950 AVKMRNGV 957
>XP_005270351
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIKQRDGV 9
           A+K R+GV
Sbjct: 965 AVKMRNGV 972
>XP_006718142
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIKQRDGV 9
            A+K R+GV
Sbjct: 996  AVKMRNGV 1003
>XP_006716479
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIKQRDG 8
          A+KQ DG
Sbjct: 91 AVKQSDG 97
>XP_005265157
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKQRDG 8
           IKQ+DG
Sbjct: 410 IKQKDG 415
>XP_005265156
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKQRDG 8
           IKQ+DG
Sbjct: 427 IKQKDG 432
>XP_006713187
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKQRDG 8
           IKQ+DG
Sbjct: 427 IKQKDG 432
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIKQRDGV 9
            A K+RDG+
Sbjct: 1396 ATKERDGL 1403
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIKQRDGV 9
            A K+RDG+
Sbjct: 1396 ATKERDGL 1403
>NP_835467
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKQRDG 8
           IKQ+DG
Sbjct: 427 IKQKDG 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.133    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 533,522
Number of extensions: 639
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package