Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1935
XP_005266703                                                           18    1935
NP_001136254                                                           17    2528
NP_001136105                                                           17    3301
NP_777562                                                              17    3301
NP_055123                                                              17    3301
NP_001238784                                                           17    3301
NP_001238780                                                           17    3301
NP_001238781                                                           17    3301
NP_001238782                                                           17    3301
XP_005256637                                                           17    3301
XP_005256636                                                           17    3301
NP_009117                                                              16    5631
XP_005260322                                                           16    5631
XP_005260321                                                           16    5631
XP_005260320                                                           16    5631
XP_006723758                                                           16    5631
XP_006723757                                                           16    5631
XP_006723756                                                           16    5631
XP_006723755                                                           16    5631
XP_006723754                                                           16    5631
XP_006723753                                                           16    5631
XP_005260319                                                           16    5631
NP_003283                                                              15    9605
NP_001186091                                                           15    9605
NP_001186090                                                           15    9605
NP_006668                                                              15    9605
NP_001186089                                                           15    9605
NP_001164491                                                           15    9605
NP_689636                                                              15    9605
NP_001164209                                                           15    9605
XP_005262135                                                           15    9605
XP_005262134                                                           15    9605
XP_005264888                                                           15    9605
XP_006713016                                                           15    9605
XP_005264887                                                           15    9605
XP_006713015                                                           15    9605
XP_006713014                                                           15    9605
XP_006713013                                                           15    9605
XP_006713012                                                           15    9605
XP_006713011                                                           15    9605
XP_005264886                                                           15    9605
XP_006713010                                                           15    9605
XP_005264885                                                           15    9605
XP_005264884                                                           15    9605
XP_005264883                                                           15    9605
XP_005264882                                                           15    9605
XP_006713009                                                           15    9605
XP_005264881                                                           15    9605
XP_005264880                                                           15    9605
XP_005245528                                                           15    9605
NP_056047                                                              15    9605
>NP_443179
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AAEAQLLEG 9
            AAEAQ LEG
Sbjct: 1996 AAEAQPLEG 2004
>XP_005266703
          Length = 1501

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AAEAQLLEG 9
            AAEAQ LEG
Sbjct: 1327 AAEAQPLEG 1335
>NP_001136254
          Length = 1481

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    AEAQLLEG 9
            AEA+LLEG
Sbjct: 1304 AEAKLLEG 1311
>NP_001136105
          Length = 880

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 640 AEAQALEG 647
>NP_777562
          Length = 345

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AAEAQLLEG 9
          AAE+QLL G
Sbjct: 14 AAESQLLPG 22
>NP_055123
          Length = 880

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 640 AEAQALEG 647
>NP_001238784
          Length = 494

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 254 AEAQALEG 261
>NP_001238780
          Length = 494

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 254 AEAQALEG 261
>NP_001238781
          Length = 494

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 254 AEAQALEG 261
>NP_001238782
          Length = 494

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 254 AEAQALEG 261
>XP_005256637
          Length = 879

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 639 AEAQALEG 646
>XP_005256636
          Length = 880

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AEAQLLEG 9
           AEAQ LEG
Sbjct: 640 AEAQALEG 647
>NP_009117
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_005260322
          Length = 1810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AAEAQLLE 8
           A EAQLLE
Sbjct: 487 AQEAQLLE 494
>XP_005260321
          Length = 2365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1042 AQEAQLLE 1049
>XP_005260320
          Length = 2370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_006723758
          Length = 2386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1063 AQEAQLLE 1070
>XP_006723757
          Length = 2404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_006723756
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_006723755
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_006723754
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_006723753
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>XP_005260319
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AAEAQLLE 8
            A EAQLLE
Sbjct: 1119 AQEAQLLE 1126
>NP_003283
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AEAQLLE 8
            AE+QLLE
Sbjct: 1120 AESQLLE 1126
>NP_001186091
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 948 AQLLEG 953
>NP_001186090
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 960 AQLLEG 965
>NP_006668
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 857 AQLLEG 862
>NP_001186089
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 958 AQLLEG 963
>NP_001164491
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAEAQLLEG 9
           AAEA+ L+G
Sbjct: 659 AAEAKYLKG 667
>NP_689636
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAEAQLLEG 9
           AAEA+ L+G
Sbjct: 659 AAEAKYLKG 667
>NP_001164209
          Length = 1182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AAEAQLLEG 9
           AAE  L+EG
Sbjct: 365 AAEKALMEG 373
>XP_005262135
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAEAQLLEG 9
           AAEA+ L+G
Sbjct: 659 AAEAKYLKG 667
>XP_005262134
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AAEAQLLEG 9
           AAEA+ L+G
Sbjct: 659 AAEAKYLKG 667
>XP_005264888
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 844 AQLLEG 849
>XP_006713016
          Length = 1404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 943 AQLLEG 948
>XP_005264887
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 861 AQLLEG 866
>XP_006713015
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 943 AQLLEG 948
>XP_006713014
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 944 AQLLEG 949
>XP_006713013
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 945 AQLLEG 950
>XP_006713012
          Length = 1373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 912 AQLLEG 917
>XP_006713011
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 958 AQLLEG 963
>XP_005264886
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 962 AQLLEG 967
>XP_006713010
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 944 AQLLEG 949
>XP_005264885
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 945 AQLLEG 950
>XP_005264884
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 947 AQLLEG 952
>XP_005264883
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 960 AQLLEG 965
>XP_005264882
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 960 AQLLEG 965
>XP_006713009
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 961 AQLLEG 966
>XP_005264881
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 962 AQLLEG 967
>XP_005264880
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AQLLEG 9
           AQLLEG
Sbjct: 962 AQLLEG 967
>XP_005245528
          Length = 2439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AEAQLLE 8
            AE+QLLE
Sbjct: 1196 AESQLLE 1202
>NP_056047
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AAEAQLLEG 9
          AAE  L+EG
Sbjct: 62 AAEKALMEG 70
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.120    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 352,481
Number of extensions: 501
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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