Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              21     229
NP_001244947                                                           18    1482
NP_758962                                                              18    1482
NP_001244946                                                           18    1482
NP_690863                                                              18    1482
XP_005276448                                                           17    2528
XP_005253328                                                           17    2528
XP_005275753                                                           17    2528
NP_057097                                                              17    4312
NP_733786                                                              17    4312
XP_006720621                                                           17    4312
XP_006720620                                                           17    4312
XP_006720619                                                           17    4312
XP_006720618                                                           17    4312
NP_001070973                                                           17    4312
NP_001070974                                                           17    4312
NP_001070972                                                           17    4312
NP_002326                                                              16    7355
NP_001025054                                                           16    7355
NP_001257639                                                           16    7355
NP_002310                                                              16    7355
XP_005274051                                                           16    7355
XP_005250404                                                           16    7355
XP_005250403                                                           16    7355
NP_005915                                                              15    9605
NP_057336                                                              15    9605
NP_004086                                                              15    9605
NP_002070                                                              15    9605
NP_055149                                                              15    9605
NP_001008409                                                           15    9605
XP_006723782                                                           15    9605
XP_006712120                                                           15    9605
XP_005264512                                                           15    9605
XP_005264511                                                           15    9605
XP_006712119                                                           15    9605
XP_005264510                                                           15    9605
XP_006712118                                                           15    9605
XP_005264509                                                           15    9605
XP_005264508                                                           15    9605
XP_006712117                                                           15    9605
XP_005264507                                                           15    9605
XP_005264506                                                           15    9605
NP_001139014                                                           15    9605
NP_001092142                                                           15    9605
>NP_443179
          Length = 2170

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AADKRVGGR 9
           AADKRVGG+
Sbjct: 515 AADKRVGGK 523
>NP_001244947
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_758962
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_001244946
          Length = 589

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           AD R+GGR
Sbjct: 112 ADNRIGGR 119
>NP_690863
          Length = 567

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ADKRVGGR 9
          AD R+GGR
Sbjct: 90 ADNRIGGR 97
>XP_005276448
          Length = 215

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DKRVGGR 9
          +KRVGGR
Sbjct: 50 EKRVGGR 56
>XP_005253328
          Length = 215

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DKRVGGR 9
          +KRVGGR
Sbjct: 50 EKRVGGR 56
>XP_005275753
          Length = 215

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DKRVGGR 9
          +KRVGGR
Sbjct: 50 EKRVGGR 56
>NP_057097
          Length = 327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           +DK +GGR
Sbjct: 140 SDKTIGGR 147
>NP_733786
          Length = 113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KRVGGR 9
          KRVGGR
Sbjct: 69 KRVGGR 74
>XP_006720621
          Length = 261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           +DK +GGR
Sbjct: 140 SDKTIGGR 147
>XP_006720620
          Length = 261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           +DK +GGR
Sbjct: 140 SDKTIGGR 147
>XP_006720619
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           +DK +GGR
Sbjct: 140 SDKTIGGR 147
>XP_006720618
          Length = 327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           +DK +GGR
Sbjct: 140 SDKTIGGR 147
>NP_001070973
          Length = 76

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KRVGGR 9
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_001070974
          Length = 107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KRVGGR 9
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_001070972
          Length = 87

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KRVGGR 9
          KRVGGR
Sbjct: 63 KRVGGR 68
>NP_002326
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AADKRVGGR 9
           A +KR GG+
Sbjct: 262 ACNKRTGGK 270
>NP_001025054
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    AADKRVGGR 9
            A+D++ GGR
Sbjct: 1194 ASDRQPGGR 1202
>NP_001257639
          Length = 109

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AADKRVGG 8
          AAD  VGG
Sbjct: 78 AADSAVGG 85
>NP_002310
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           A KRVGG+
Sbjct: 641 AVKRVGGK 648
>XP_005274051
          Length = 1653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AADKRVGGR 9
           A +KR GG+
Sbjct: 262 ACNKRTGGK 270
>XP_005250404
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           A KRVGG+
Sbjct: 579 AVKRVGGK 586
>XP_005250403
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           A KRVGG+
Sbjct: 602 AVKRVGGK 609
>NP_005915
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKRVGGR 9
           A+KR GG+
Sbjct: 159 AEKRSGGK 166
>NP_057336
          Length = 4857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4781 SSDKRVG 4787
>NP_004086
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   DKRVGG 8
           DKR GG
Sbjct: 104 DKRAGG 109
>NP_002070
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DKRVGG 8
           +KRVGG
Sbjct: 98  EKRVGG 103
>NP_055149
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AADKRVGG 8
           ++DK++GG
Sbjct: 200 SSDKKMGG 207
>NP_001008409
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DKRVGG 8
           +KRVGG
Sbjct: 378 EKRVGG 383
>XP_006723782
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DKRVGG 8
           +KRVGG
Sbjct: 375 EKRVGG 380
>XP_006712120
          Length = 4812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4736 SSDKRVG 4742
>XP_005264512
          Length = 4840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4764 SSDKRVG 4770
>XP_005264511
          Length = 4847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4771 SSDKRVG 4777
>XP_006712119
          Length = 4851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4775 SSDKRVG 4781
>XP_005264510
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4785 SSDKRVG 4791
>XP_006712118
          Length = 4864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4788 SSDKRVG 4794
>XP_005264509
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4794 SSDKRVG 4800
>XP_005264508
          Length = 4875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4799 SSDKRVG 4805
>XP_006712117
          Length = 4878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4802 SSDKRVG 4808
>XP_005264507
          Length = 4880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4804 SSDKRVG 4810
>XP_005264506
          Length = 4884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AADKRVG 7
            ++DKRVG
Sbjct: 4808 SSDKRVG 4814
>NP_001139014
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4 KRVGGR 9
         +RVGGR
Sbjct: 2 RRVGGR 7
>NP_001092142
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   DKRVGGR 9
           D R+GG+
Sbjct: 421 DNRIGGK 427
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.137    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 574,504
Number of extensions: 862
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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