Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     665
XP_005273257                                                           19     665
NP_055994                                                              17    4312
NP_001138586                                                           17    4312
NP_001265855                                                           17    4312
NP_001265856                                                           17    4312
NP_006176                                                              17    4312
NP_001265858                                                           17    4312
NP_064703                                                              17    4312
NP_114124                                                              17    4312
NP_001271266                                                           17    4312
NP_001273490                                                           17    4312
NP_056157                                                              17    4312
XP_006718633                                                           17    4312
XP_006718632                                                           17    4312
XP_006718631                                                           17    4312
XP_006718630                                                           17    4312
XP_006718629                                                           17    4312
XP_006718628                                                           17    4312
XP_006718627                                                           17    4312
XP_006718626                                                           17    4312
XP_006718625                                                           17    4312
XP_005248532                                                           17    4312
XP_005248531                                                           17    4312
XP_006714646                                                           17    4312
XP_006714645                                                           17    4312
XP_005247707                                                           17    4312
XP_005247706                                                           17    4312
XP_005247705                                                           17    4312
XP_006713773                                                           17    4312
NP_808881                                                              16    5631
NP_065857                                                              16    7355
NP_057336                                                              16    7355
NP_001014364                                                           16    7355
NP_690000                                                              16    7355
XP_005274540                                                           16    7355
XP_005274539                                                           16    7355
XP_005267307                                                           16    7355
XP_006720066                                                           16    7355
XP_006712120                                                           16    7355
XP_005264512                                                           16    7355
XP_005264511                                                           16    7355
XP_006712119                                                           16    7355
XP_005264510                                                           16    7355
XP_006712118                                                           16    7355
XP_005264509                                                           16    7355
XP_005264508                                                           16    7355
XP_006712117                                                           16    7355
XP_005264507                                                           16    7355
XP_005264506                                                           16    7355
NP_001013                                                              15    9605
NP_001244896                                                           15    9605
NP_001244897                                                           15    9605
NP_004995                                                              15    9605
NP_001271297                                                           15    9605
NP_001271296                                                           15    9605
NP_001137236                                                           15    9605
NP_001137235                                                           15    9605
NP_570140                                                              15    9605
NP_149111                                                              15    9605
NP_001258011                                                           15    9605
NP_940929                                                              15    9605
NP_919276                                                              15    9605
NP_001273380                                                           15    9605
XP_006725072                                                           15    9605
XP_006725071                                                           15    9605
XP_006725070                                                           15    9605
XP_005249718                                                           15    9605
XP_005248440                                                           15    9605
XP_006714568                                                           15    9605
XP_005248439                                                           15    9605
>NP_064450
          Length = 1722

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAAAKKHRA 9
           AA AKKHRA
Sbjct: 463 AAPAKKHRA 471
>XP_005273257
          Length = 1726

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAAAKKHRA 9
           AA AKKHRA
Sbjct: 463 AAPAKKHRA 471
>NP_055994
          Length = 1297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AAAKKHRA 9
            A AK+HRA
Sbjct: 1040 ARAKRHRA 1047
>NP_001138586
          Length = 1236

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAAKKHRA 9
           A AK+HRA
Sbjct: 979 ARAKRHRA 986
>NP_001265855
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 380 AKKHRA 385
>NP_001265856
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 270 AKKHRA 275
>NP_006176
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>NP_001265858
          Length = 490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 254 AKKHRA 259
>NP_064703
          Length = 526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AAKKHR 8
           AAKKHR
Sbjct: 484 AAKKHR 489
>NP_114124
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAAAKKHR 8
           +AAAK HR
Sbjct: 121 SAAAKSHR 128
>NP_001271266
          Length = 1197

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAAKKHRA 9
           A AK+HRA
Sbjct: 940 ARAKRHRA 947
>NP_001273490
          Length = 2101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>NP_056157
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 410 AKKHRA 415
>XP_006718633
          Length = 2101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718632
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718631
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718630
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718629
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718628
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718627
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718626
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_006718625
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AAAAKKHR 8
            AAA K+HR
Sbjct: 1375 AAAEKRHR 1382
>XP_005248532
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  AKKHRA 9
          AKKHRA
Sbjct: 87 AKKHRA 92
>XP_005248531
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 110 AKKHRA 115
>XP_006714646
          Length = 550

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 314 AKKHRA 319
>XP_006714645
          Length = 604

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AKKHRA 9
           AKKHRA
Sbjct: 368 AKKHRA 373
>XP_005247707
          Length = 299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AAKKHR 8
           AAKKHR
Sbjct: 257 AAKKHR 262
>XP_005247706
          Length = 320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AAKKHR 8
           AAKKHR
Sbjct: 278 AAKKHR 283
>XP_005247705
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AAKKHR 8
           AAKKHR
Sbjct: 329 AAKKHR 334
>XP_006713773
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AAKKHR 8
           AAKKHR
Sbjct: 451 AAKKHR 456
>NP_808881
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAAKK R
Sbjct: 89 AAAAKKSR 96
>NP_065857
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AAAAKKH 7
           A AAKKH
Sbjct: 239 AIAAKKH 245
>NP_057336
          Length = 4857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4794 AAALKRHTA 4802
>NP_001014364
          Length = 2391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AAAAKKHR 8
           A+ +KKHR
Sbjct: 96  ASGSKKHR 103
>NP_690000
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAAAKKHR 8
           AAAA +HR
Sbjct: 659 AAAADEHR 666
>XP_005274540
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAAAKKHR 8
           AAAA +HR
Sbjct: 631 AAAADEHR 638
>XP_005274539
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AAAAKKHR 8
           AAAA +HR
Sbjct: 659 AAAADEHR 666
>XP_005267307
          Length = 788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AAAAKKH 7
           A AAKKH
Sbjct: 239 AIAAKKH 245
>XP_006720066
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AAAAKKH 7
           A AAKKH
Sbjct: 239 AIAAKKH 245
>XP_006712120
          Length = 4812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4749 AAALKRHTA 4757
>XP_005264512
          Length = 4840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4777 AAALKRHTA 4785
>XP_005264511
          Length = 4847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4784 AAALKRHTA 4792
>XP_006712119
          Length = 4851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4788 AAALKRHTA 4796
>XP_005264510
          Length = 4861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4798 AAALKRHTA 4806
>XP_006712118
          Length = 4864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4801 AAALKRHTA 4809
>XP_005264509
          Length = 4870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4807 AAALKRHTA 4815
>XP_005264508
          Length = 4875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4812 AAALKRHTA 4820
>XP_006712117
          Length = 4878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4815 AAALKRHTA 4823
>XP_005264507
          Length = 4880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4817 AAALKRHTA 4825
>XP_005264506
          Length = 4884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AAAAKKHRA 9
            AAA K+H A
Sbjct: 4821 AAALKRHTA 4829
>NP_001013
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AAAAKKH 7
           AAA KKH
Sbjct: 139 AAANKKH 145
>NP_001244896
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AAAKKHR 8
           +AAK+HR
Sbjct: 254 SAAKEHR 260
>NP_001244897
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AAAKKHR 8
           +AAK+HR
Sbjct: 270 SAAKEHR 276
>NP_004995
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AAAAKKH 7
          AAAAKK+
Sbjct: 49 AAAAKKY 55
>NP_001271297
          Length = 155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AAAAKKH 7
          AAAAKK+
Sbjct: 18 AAAAKKY 24
>NP_001271296
          Length = 172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AAAAKKH 7
          AAAAKK+
Sbjct: 49 AAAAKKY 55
>NP_001137236
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAAAKKHR 8
           AAAA++H+
Sbjct: 255 AAAAQRHQ 262
>NP_001137235
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAAAKKHR 8
           AAAA++H+
Sbjct: 255 AAAAQRHQ 262
>NP_570140
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAAAKKHR 8
           AAAA++H+
Sbjct: 219 AAAAQRHQ 226
>NP_149111
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>NP_001258011
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>NP_940929
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AAKKHR 8
          AA+KHR
Sbjct: 15 AARKHR 20
>NP_919276
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AAAKKHR 8
           +AAK+HR
Sbjct: 244 SAAKEHR 250
>NP_001273380
          Length = 179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AAKKHR 8
          AA+KHR
Sbjct: 15 AARKHR 20
>XP_006725072
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>XP_006725071
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>XP_006725070
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>XP_005249718
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AAAKKHR 8
           +AAK+HR
Sbjct: 152 SAAKEHR 158
>XP_005248440
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>XP_006714568
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
>XP_005248439
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AAAAKKHR 8
          AAAA+K R
Sbjct: 9  AAAARKRR 16
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.105    0.273 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 571,362
Number of extensions: 552
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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