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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 3
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1015Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium marinumMycobacterium marinum (ATCC 927) MIC = 0.95 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1139NK-2 KILRGVCKKIMRTFLRRISKDILTGKKFreeAmidationNoneLinear27LCationicProtein DerivedCore region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells Mycobacterium marinum Mycobacterium marinum (ATCC 927) IC90 = 3.5 μg/ml In vitroRAW264.7 Moderate killing was observedNo significant reduction in cell viability either treating alone or combinationNone NANAPermeabilization of the bacterial cell membrane Cell envelopeNoneAntibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans)201323689720
antitb_1143LLKKK-18 KEFKRIVKRIKKFLRKLFreeFreeNoneLinear17LAmphipathicProtein DerivedVariant of LL-40Mycobacterium marinum Mycobacterium marinum (ATCC 927) IC 90 = 1 μg/ml In vitroRAW264.7 Moderate killing was observedNo significant reduction in cell viability either treating alone or combinationNone NANAPermeabilization of the bacterial cell membrane Cell envelopeNoneNone201323689720