| Primary information |
|---|
| ID | antitb_1141, |
| Name | 23689720 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKL |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 17 |
| Source | L |
| Origin | Amphipathic |
| Species | Protein Derived |
| Strain | Variant of LL-38 |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Cell Line | 0.5 ppm of NP-1 combined with 1 μg/ml of LLKKK-18 kills 50% of M. smegmatis |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | NP-1 in combination with LLKKK-18 kills 65% of mycobacteria compared to NP-1 or LLKKK-18 alone. |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | AgNPs synthesiszed only in the presence of a plant Alstonia macrophylla (NP-1). |
| Year of Publication | None |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1142, |
| Name | 23689720 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKL |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 17 |
| Source | L |
| Origin | Amphipathic |
| Species | Protein Derived |
| Strain | Variant of LL-39 |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Cell Line | 0.5 ppm of NP-2 combined with 1 μg/ml of LLKKK-18 kills 89% of M. smegmatis |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | No significant reduction |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | AgNPs synthesiszed only in the presence of a fungal Trichoderma sp. (NP-2). |
| Year of Publication | None |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1143, |
| Name | 23689720 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKL |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 17 |
| Source | L |
| Origin | Amphipathic |
| Species | Protein Derived |
| Strain | Variant of LL-40 |
| Inhibition Concentration | Mycobacterium marinum |
| In Vitro/ In vivo | Mycobacterium marinum (ATCC 927) |
| Cell Line | IC 90 = 1 μg/ml |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | Moderate killing was observed |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | None |
| Year of Publication | None |
Tertiary Structure
(Technique) | Not Predicted), |