| Primary information |
|---|
| ID | antitb_1141 |
| Peptide Name | LLKKK-18 |
| Sequence | KEFKRIVKRIKKFLRKL |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 17 |
| Chirality | L |
| Nature | Amphipathic |
| Source | Protein Derived |
| Origin | Variant of LL-38 |
| Species | Mycobacterium smegmatis |
| Strain | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Inhibition Concentartion | 0.5 ppm of NP-1 combined with 1 μg/ml of LLKKK-18 kills 50% of M. smegmatis |
| In vitro/In vivo | In vitro |
| Cell Line | RAW264.7 |
| Inhibition Concentartion | NP-1 in combination with LLKKK-18 kills 65% of mycobacteria compared to NP-1 or LLKKK-18 alone. |
| Cytotoxicity | No significant reduction in cell viability either treating alone or combination |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Permeabilization of the bacterial cell membrane |
| Target | Cell envelope |
| Combination Therapy | AgNPs synthesiszed only in the presence of a plant Alstonia macrophylla (NP-1). |
| Other Activities | None |
| Pubmed ID | 23689720 |
| Year of Publication | 2013 |
| 3-D Structure |  View in Jmol or Download Structure |