Potential Vaccine Candidates (Conserved Epitopes)
Following table provides list of conserved peptides and their potential immunogenicity that include simulation of T- and B-cells. Immunogenicitiy of these peptides have been using immuno-informaitcs pipeline. The predicted immune response can be browsed by visiting the column of gene or column of conserved 9mer for each entry. The NCBI link for each protein of all species are given to facilitate user. The facility for sorting and searching has been implemented to extract the user-desired peptides.
| Sr. No. | Protein | Symbol | Conserved 9mers | Bundibugyo (BDBV) | Reston (RESTV) | Sudan (SUDV) | Taiforest (TAFV) | Mayinga Zaire 1976 (EBOV) |
| 1 | Major Nucleoprotein | NP | 147 | YP_003815432.1 | NP_690580.1 | YP_138520.1 | YP_003815423.1 | NP_066243.1 |
| 2 | Polymerase complex | VP35 | 35 | YP_003815433.1 | NP_690581.1 | YP_138521.1 | YP_003815424.1 | NP_066244.1 |
| 3 | Matrix Protein | VP40 | 41 | YP_003815434.1 | NP_690582.1 | YP_138522.1 | YP_003815425.1 | NP_066245.1 |
| 4 | Glycoprotein (Spike) | GP | 20 | YP_003815435.1 | NP_690583.1 | YP_138523.1 | YP_003815426.1 | NP_066246.1 |
| 5 | Glycoprotein (Second Secreted) | ssGP | 9 | YP_003815437.1 | NP_690583.1 | YP_138523.1 | YP_003815428.1 | NP_066248.1 |
| 6 | Minor Nucleoprotein | VP30 | 12 | YP_003815438.1 | NP_690585.1 | YP_138525.1 | YP_003815429.1 | NP_066249.1 |
| 7 | Membrane Associated Protein | VP24 | 7 | YP_003815439.1 | NP_690586.1 | YP_138526.1 | YP_003815430.1 | NP_066250.1 |
| 8 | Polymerase | L | 358 | YP_003815440.1 | NP_690587.1 | YP_138527.1 | YP_003815431.1 | NP_066251.1 |