Welcome to Home page of EbolaVCR

Ebola Virus Computational Resources (EbolaVCR) is the in silico resources developed to facilitate scientific community fighting against deadly virus EBOLA. This server enlists possible vaccine candidates, therapeutic siRNAs and other related resources.
Reference: Dhanda et. al. (2016) A web-based resource for designing therapeutics against Ebola Virus. Sci Rep. 6:24782.

Sequence Alignment of Ebola Proteins/Antigens and mRNAs

Ebola species have 7 proteins which may serve as potential antigens for vaccine. It is important to understand conservation in these antigens. This page contains alignment of each antigen of Ebola that allows user to identify conserved regions.

Links to files contain information about predicted epitopes in each protein of each strain of Ebola virus as well as links to alignment file.
ProteinsBundibugyo (BDBV)Sudan (SUDV)Reston (RESTV)Taiforest (TAFV)Zaire (EBOV)Protein Alignments
Nuceloprotein YP_003815432.1 YP_138520.1 NP_690580.1 YP_003815423.1 NP_066243.1 NP .aln
Polymerase complex YP_003815433.1 YP_138521.1 NP_690581.1 YP_003815424.1 NP_066244.1 VP35 .aln
Matrix Protein YP_003815434.1 YP_138522.1 NP_690582.1 YP_003815425.1 NP_066245.1 VP40 .aln
GP (Spike Glycoprotein) YP_003815435.1 YP_138523.1 NP_690583.1 YP_003815426.1 NP_066246.1 gp_str_spike .aln
GP (Small Secrted Glycoprotein) YP_003815436.1 YP_138524.1 NP_690584.1 YP_003815427.1 NP_066247.1 small_secreted .aln
GP (Second Secreted Glycoprotein) YP_003815437.1 ---- YP_003815428.1 NP_066248.1 second_gp .aln
Minor Nucleoprotein YP_003815438.1 YP_138525.1 NP_690585.1 YP_003815429.1 NP_066249.1 minor_NM .aln
Membrane Assosicated Protein YP_003815439.1 YP_138526.1 NP_690586.1 YP_003815430.1 NP_066250.1 VP24 .aln
RNA dependent RNA Polymerase YP_003815440.1 YP_138527.1 NP_690587.1 YP_003815431.1 NP_066251.1 rna_polymerase .aln