Home Page

Due to the importance of foreign- and host-derived DNA for induction of protective reactions against pathogens and autoimmune disorders, respectively, a great deal of research has been devoted to studying the immunostimulatory properties of CpGs and the function of TLR9 (reviewed in [7]). In mammals, the receptor is found in the endoplasmic reticulum in resting immune cells. Upon exposure of the cells to CpG DNA, TLR9 translocates to the endosomal compartments [8], where it may interact with its ligand. The binding of the receptor to DNA seems to be sequence independent but it requires low pH conditions and proteolytical activation [9]. Once activated, the receptor signals through Myeloid differentiation primary response gene 88 (MyD88) to activate transcription factors including nuclear factor kappa-B (NFkB) and interferon-regulatory factor 7 (IRF7) involved in the upregulation of proinflammatory genes and type I interferon (IFN), respectively.

Lorem lipsum

Morbi fermentum condimentum felis, commodo vestibulum sem mattis sed. Aliquam magna ante, mollis vitae tincidunt in, malesuada vitae turpis. Sed aliquam libero ut velit bibendum consectetur. Quisque sagittis, est in laoreet semper, enim dui consequat felis, faucibus ornare urna velit nec leo. Maecenas condimentum velit vitae est lobortis fermentum. In tristique sem vitae metus ornare luctus tempus nisl volutpat. Integer et est id nisi tempus pharetra sagittis et libero.