Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0280 | Curdlan Click for more detail | Alcaligenes faecalis(Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages. | Dectin-1 | C type Lectin (CTL/CLR) | Human | PBMCs and monocyte-derived macrophages. | NA | Q9BXN2.fasta | Q9BXN2 | 247 | It is resoonsible for the immuno-inflammation in the host cell. | ELISA | 18549457 | 2008 | Pubchem Assay |
| PRRID_0280 | Curdlan Click for more detail | Alcaligenes faecalis(Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages. | Dectin-1 | C type Lectin (CTL/CLR) | Human | PBMCs and monocyte-derived macrophages. | NA | Q9BXN2.fasta | Q9BXN2 | 247 | It is resoonsible for the immuno-inflammation in the host cell. | ELISA | 18549457 | 2008 | Pubchem Assay |
| PRRID_0847 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0847 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0848 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0848 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0849 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0849 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0850 | Zymosan Click for more detail | gram-positive bacteria and yeast | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | cerebral endothelial cell line hCMEC/D3 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It's activation causes tight junction disruption in CECs | NA | 20637248 | 2010 | NA |
| PRRID_0850 | Zymosan Click for more detail | gram-positive bacteria and yeast | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | cerebral endothelial cell line hCMEC/D3 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It's activation causes tight junction disruption in CECs | NA | 20637248 | 2010 | NA |
| PRRID_0851 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0851 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0852 | β -1,3-glucan Click for more detail | Fungi | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | NA | PGRP-S2 | Peptidoglycan Recognition Receptor (PGRPs) | Chlamys farreri | mantle, gill, kidney and gonad | NA | Q9VYX7.fasta | Q9VYX7 | 203 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0852 | β -1,3-glucan Click for more detail | Fungi | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | NA | PGRP-S2 | Peptidoglycan Recognition Receptor (PGRPs) | Chlamys farreri | mantle, gill, kidney and gonad | NA | Q9VYX7.fasta | Q9VYX7 | 203 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0859 | β -1,3-glucan Click for more detail | Vibrio harveyi (Bacteria) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | NA | GNBP | Gram-negative Bacteria-binding Protein (GNBPs) | Artemia sinica | NA | NA | NA | NA | NA | Have cytoprotective effect | NA | 20699104 | 2010 | NA |
| PRRID_0859 | β -1,3-glucan Click for more detail | Vibrio harveyi (Bacteria) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | NA | GNBP | Gram-negative Bacteria-binding Protein (GNBPs) | Artemia sinica | NA | NA | NA | NA | NA | Have cytoprotective effect | NA | 20699104 | 2010 | NA |
| PRRID_0972 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0972 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0973 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0973 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0974 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21955443 | 2011 | NA |
| PRRID_0974 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21955443 | 2011 | NA |
| PRRID_0975 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 21955443 | 2011 | NA |
| PRRID_0975 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 21955443 | 2011 | NA |
| PRRID_1166 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1166 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1167 | Zymosan Click for more detail | Various pathogens (others) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1167 | Zymosan Click for more detail | Various pathogens (others) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1168 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1168 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1170 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1170 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1171 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1171 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1676 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | activates macrophages via TLR2. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24830024 | 2014 | NA |
| PRRID_1676 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | activates macrophages via TLR2. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24830024 | 2014 | NA |
| PRRID_1677 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | activates macrophages via TLR2. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24830024 | 2014 | NA |
| PRRID_1677 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | activates macrophages via TLR2. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24830024 | 2014 | NA |
| PRRID_1678 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | mast cells | cell surface | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | Real-time PCR | 24818634 | 2014 | Pubchem_assay |
| PRRID_1678 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | mast cells | cell surface | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | Real-time PCR | 24818634 | 2014 | Pubchem_assay |
| PRRID_1679 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1679 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1680 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | O60603.fasta | O60603 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1680 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | O60603.fasta | O60603 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1681 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1681 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1682 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | O60603.fasta | O60603 | 784 | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1682 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | O60603.fasta | O60603 | 784 | TLR2 cooperates with TLR6 and CD14 in response to zymosan | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1683 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1683 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1684 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1684 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1685 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1685 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1686 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1686 | Zymosan Click for more detail | Fungi(Yeast) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1954 | Beta glucans Click for more detail | Candida albicans(fungi) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | Activation of CLEC7A | CLEC7A | C type Lectin (CTL/CLR) | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | critical functions in host defense against Candida albicans invasion | NA | 28824166 | 2017 | Pubchem_assay |
| PRRID_1954 | Beta glucans Click for more detail | Candida albicans(fungi) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glucan | Natural | Activation of CLEC7A | CLEC7A | C type Lectin (CTL/CLR) | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | critical functions in host defense against Candida albicans invasion | NA | 28824166 | 2017 | Pubchem_assay |
| PRRID_2696 | Zymosan Click for more detail | Fungi(Yeast) | NA | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | NA | NA | 29028369 | 2017 | Pubchem_assay |
| PRRID_2696 | Zymosan Click for more detail | Fungi(Yeast) | NA | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | NA | NA | 29028369 | 2017 | Pubchem_assay |
| PRRID_2697 | Zymosan Click for more detail | Fungi(Yeast) | NA | NA | Glucan | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Nondepleted zymosan also binds TLR2 | NA | 28167651 | 2017 | NA |
| PRRID_2697 | Zymosan Click for more detail | Fungi(Yeast) | NA | NA | Glucan | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Nondepleted zymosan also binds TLR2 | NA | 28167651 | 2017 | NA |