Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2246Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2246Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2266Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2266Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2276Lipopolysaccharide (LPS)

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Vibrio harveyi (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalPathogenic infectionFmLC5C type Lectin (CTL/CLR)Fenneropenaeus merguiensishemocytestwo similar carbohydrate recognition domains (CRDs), each CRD contains a Ca2+ binding site-2 and a QPD motif specific for galactose-bindingNANANANAqRT-PCR289585862017NA
PRRID_2276Lipopolysaccharide (LPS)

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Vibrio harveyi (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalPathogenic infectionFmLC5C type Lectin (CTL/CLR)Fenneropenaeus merguiensishemocytestwo similar carbohydrate recognition domains (CRDs), each CRD contains a Ca2+ binding site-2 and a QPD motif specific for galactose-bindingNANANANAqRT-PCR289585862017NA
PRRID_2277Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA282889102017NA
PRRID_2277Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA282889102017NA
PRRID_2278Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA282889102017NA
PRRID_2278Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA282889102017NA
PRRID_2279Lipopolysaccharide (LPS)

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserMrLecC type Lectin (CTL/CLR)NANANANANANANANA278183422017NA
PRRID_2279Lipopolysaccharide (LPS)

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserMrLecC type Lectin (CTL/CLR)NANANANANANANANA278183422017NA
PRRID_2280Peptidoglycan (PGN)

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Gram-negative and Gram-positive bacteriaNANAPeptidoglycanNaturalelicit innate immune responserMrLecC type Lectin (CTL/CLR)NANANANANANANANA278183422017NA
PRRID_2280Peptidoglycan (PGN)

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Gram-negative and Gram-positive bacteriaNANAPeptidoglycanNaturalelicit innate immune responserMrLecC type Lectin (CTL/CLR)NANANANANANANANA278183422017NA
PRRID_2281Lipopolysaccharide (LPS)

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMrCTLC type Lectin (CTL/CLR)NANANANANANANANA276208192017NA
PRRID_2281Lipopolysaccharide (LPS)

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMrCTLC type Lectin (CTL/CLR)NANANANANANANANA276208192017NA
PRRID_2282Peptidoglycan (PGN)

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Gram-negative and Gram-positive bacteriaNANAPeptidoglycanNaturalelicit innate immune responseMrCTLC type Lectin (CTL/CLR)NANANANANANANANA276208192017NA
PRRID_2282Peptidoglycan (PGN)

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Gram-negative and Gram-positive bacteriaNANAPeptidoglycanNaturalelicit innate immune responseMrCTLC type Lectin (CTL/CLR)NANANANANANANANA276208192017NA
PRRID_2325Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseSpMBPC type Lectin (CTL/CLR)Scylla paramamosainNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2325Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseSpMBPC type Lectin (CTL/CLR)Scylla paramamosainNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2326Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseMjLecAC type Lectin (CTL/CLR)Marsupenaeus japonicusNASingle-CRD C-type lectins containing EPN (Glu- Pro-Asn) motifNANANANANA290551892017NA
PRRID_2326Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseMjLecAC type Lectin (CTL/CLR)Marsupenaeus japonicusNASingle-CRD C-type lectins containing EPN (Glu- Pro-Asn) motifNANANANANA290551892017NA
PRRID_2327Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseFcLec1C type Lectin (CTL/CLR)F. chinensisNANANANANANANA290551892017NA
PRRID_2327Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONANANaturalelicit innate immune responseFcLec1C type Lectin (CTL/CLR)F. chinensisNANANANANANANA290551892017NA
PRRID_2328Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONANANaturalelicit innate immune responseFcLec3C type Lectin (CTL/CLR)F. chinensisNANANANANANANA290551892017NA
PRRID_2328Mannose

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BacteriaC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONANANaturalelicit innate immune responseFcLec3C type Lectin (CTL/CLR)F. chinensisNANANANANANANA290551892017NA
PRRID_2329Mannose and fucose

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L. monocytogenes (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLEC5ACLEC5AC type Lectin (CTL/CLR)Humanmonocytes, macrophages and neutrophils.NAQ14DL9.fastaQ14DL9165secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10.Binding assay288241662017Pubchem_assay
PRRID_2329Mannose and fucose

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L. monocytogenes (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLEC5ACLEC5AC type Lectin (CTL/CLR)Humanmonocytes, macrophages and neutrophils.NAQ14DL9.fastaQ14DL9165secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10.Binding assay288241662017Pubchem_assay
PRRID_2343Microbial DNA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)NaturalBacterial infectionDC-SIGNC type Lectin (CTL/CLR)HumanmonocytesNANANANANANA289769992017NA
PRRID_2343Microbial DNA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)NaturalBacterial infectionDC-SIGNC type Lectin (CTL/CLR)HumanmonocytesNANANANANANA289769992017NA
PRRID_2345mono- and di-acylated derivatives

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NANANAAgonistSyntheticActivation of CLRs.MincleC type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)Q9ULY5.fastaQ9ULY5219inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017Pubchem_assay
PRRID_2345mono- and di-acylated derivatives

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NANANAAgonistSyntheticActivation of CLRs.MincleC type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)Q9ULY5.fastaQ9ULY5219inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017Pubchem_assay
PRRID_2419NA

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VirusNANANANaturalNACLEC4M (L-SIGN)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ9H2X3.fastaQ9H2X3399NANA290662552017Pubchem_assay
PRRID_2419NA

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VirusNANANANaturalNACLEC4M (L-SIGN)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ9H2X3.fastaQ9H2X3399NANA290662552017Pubchem_assay
PRRID_2426NA

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NANANANANaturalNAFcLec5C type Lectin (CTL/CLR)F. chinensishemolymph and hepatopancreasNANANANANANA290551892017NA
PRRID_2426NA

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NANANANANaturalNAFcLec5C type Lectin (CTL/CLR)F. chinensishemolymph and hepatopancreasNANANANANANA290551892017NA
PRRID_2438NA

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S. cerevisiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCREP4C type Lectin (CTL/CLR)B. glabRataNANANANANANAtranscriptomic data290517622017NA
PRRID_2438NA

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S. cerevisiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCREP4C type Lectin (CTL/CLR)B. glabRataNANANANANANAtranscriptomic data290517622017NA
PRRID_2442NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCTL4C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX81.fastaB2FX81150NANA290517622017Pubchem_assay
PRRID_2442NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCTL4C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX81.fastaB2FX81150NANA290517622017Pubchem_assay
PRRID_2443NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Damage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseCTLMA2C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX57.fastaB2FX57165NANA290517622017Pubchem_assay
PRRID_2443NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Damage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseCTLMA2C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX57.fastaB2FX57165NANA290517622017Pubchem_assay
PRRID_2460NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLR.CaNTCC type Lectin (CTL/CLR)Carassius auratusliver, spleen and head-kidneyCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2460NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLR.CaNTCC type Lectin (CTL/CLR)Carassius auratusliver, spleen and head-kidneyCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2470NA

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Gram-negative and Gram-positive bacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrMjGCTLC type Lectin (CTL/CLR)Marsupenaeus japonicusHemocytesCRD with a QAP motif.NANANAacts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation.Bacterial agglutination assay283748482017NA
PRRID_2470NA

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Gram-negative and Gram-positive bacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrMjGCTLC type Lectin (CTL/CLR)Marsupenaeus japonicusHemocytesCRD with a QAP motif.NANANAacts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation.Bacterial agglutination assay283748482017NA
PRRID_2494NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2494NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2539Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2539Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2541Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2541Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2544Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2544Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2566polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticActivation of CLRs.CaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2566polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticActivation of CLRs.CaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2571Polyman26

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NANANAAgonistSyntheticActivation of CLRs.Dectin-2C type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)Q6EIG7.fastaQ6EIG7209inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017Pubchem_assay
PRRID_2571Polyman26

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NANANAAgonistSyntheticActivation of CLRs.Dectin-2C type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)Q6EIG7.fastaQ6EIG7209inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017Pubchem_assay
PRRID_2612SAP130

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dead or dying cells(others)NANANANaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay
PRRID_2612SAP130

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dead or dying cells(others)NANANANaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay
PRRID_2633spliceosome- associated protein 130

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NANANAProteinNaturalelicit innate immune responseMincleC type Lectin (CTL/CLR)NANANANANANANANA288015212017NA
PRRID_2633spliceosome- associated protein 130

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NANANAProteinNaturalelicit innate immune responseMincleC type Lectin (CTL/CLR)NANANANANANANANA288015212017NA
PRRID_2636Staphylococcus aureus

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Gram-positive bacteriaNANAProteinNaturalelicit innate immune responsePmCLecC type Lectin (CTL/CLR)NANANANANANANANA278766222017NA
PRRID_2636Staphylococcus aureus

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Gram-positive bacteriaNANAProteinNaturalelicit innate immune responsePmCLecC type Lectin (CTL/CLR)NANANANANANANANA278766222017NA
PRRID_2639 S. Hemolyticus

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Gram-positive bacteriaNANAProteinNaturalelicit innate immune responsePmCLecC type Lectin (CTL/CLR)NANANANANANANANA278766222017NA
PRRID_2639 S. Hemolyticus

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Gram-positive bacteriaNANAProteinNaturalelicit innate immune responsePmCLecC type Lectin (CTL/CLR)NANANANANANANANA278766222017NA
PRRID_2657trehalose 6,6′-dimycolate

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Mycobacteria (Bacteria)CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)ONAGlycolipidNaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay
PRRID_2657trehalose 6,6′-dimycolate

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Mycobacteria (Bacteria)CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)ONAGlycolipidNaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay