Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1895	6-O-stearoyl-MDP (L18- MDP) Click for more detail	NA	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor C2 (NLRC2)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	NA	NA	NA	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	NA
PRRID_1895	6-O-stearoyl-MDP (L18- MDP) Click for more detail	NA	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor C2 (NLRC2)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	NA	NA	NA	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	NA
PRRID_2051	flg22 Click for more detail	Bacteria	QRLSTGSRINSAKDDAAGLQIA	22	Peptide	Natural	It bind to the FLS2 and incites the downstream cascade.	Receptor Like Kinase (RLK)	Pattern recognition receptor (PRR)	NA	NA	Leucine-Rich-Repeat (LRR) ectodomain (LRR-RLK)	NA	NA	NA	NA	NA	29083116	2017	NA
PRRID_2051	flg22 Click for more detail	Bacteria	QRLSTGSRINSAKDDAAGLQIA	22	Peptide	Natural	It bind to the FLS2 and incites the downstream cascade.	Receptor Like Kinase (RLK)	Pattern recognition receptor (PRR)	NA	NA	Leucine-Rich-Repeat (LRR) ectodomain (LRR-RLK)	NA	NA	NA	NA	NA	29083116	2017	NA
PRRID_2332	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2332	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2333	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Rat	Hippocampus	NA	D9I2G4 .fasta	D9I2G4	1218	NLRP1 inflammasome activation in aging	NA	28801521	2017	Pubchem_assay
PRRID_2333	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Rat	Hippocampus	NA	D9I2G4 .fasta	D9I2G4	1218	NLRP1 inflammasome activation in aging	NA	28801521	2017	Pubchem_assay
PRRID_2334	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28801521	2017	Pubchem_assay
PRRID_2334	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28801521	2017	Pubchem_assay
PRRID_2335	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	hippocampus (neurons)	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_2335	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	hippocampus (neurons)	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_2336	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	models of AD	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_2336	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	models of AD	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_2337	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2337	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2338	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	Brain	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2338	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	Brain	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2339	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2339	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2340	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2340	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2341	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	NA	NA	NA	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	NA
PRRID_2341	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	NA	NA	NA	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	NA

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