Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2427NA

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BacteriaNANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2427NA

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BacteriaNANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2428NA

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S. cerevisiae (Bacteria)NANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2428NA

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S. cerevisiae (Bacteria)NANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2429NA

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V. parahaemolyticus (Bacteria)NANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2429NA

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V. parahaemolyticus (Bacteria)NANANANaturalNAPurified rFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2430NA

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S. aureus, E. coli and Pichia pastoris (Bacteria)NANANANaturalNAEsLecAPattern recognition receptor (PRR)E. sinensisNANANANANANANA290551892017NA
PRRID_2430NA

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S. aureus, E. coli and Pichia pastoris (Bacteria)NANANANaturalNAEsLecAPattern recognition receptor (PRR)E. sinensisNANANANANANANA290551892017NA
PRRID_2431NA

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S. aureus, E. coli and Pichia pastoris (Bacteria)NANANANaturalNAEsLecGPattern recognition receptor (PRR)E. sinensisNANANANANANANA290551892017NA
PRRID_2431NA

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S. aureus, E. coli and Pichia pastoris (Bacteria)NANANANaturalNAEsLecGPattern recognition receptor (PRR)E. sinensisNANANANANANANA290551892017NA
PRRID_2434NA

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V. anguillarum (Bacteria)NANANANaturalNAhFcLec4Pattern recognition receptor (PRR)Marsupenaeus japonicusNANANANANANANA290551892017NA
PRRID_2434NA

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V. anguillarum (Bacteria)NANANANaturalNAhFcLec4Pattern recognition receptor (PRR)Marsupenaeus japonicusNANANANANANANA290551892017NA
PRRID_2435NA

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V. harveyi and V. parahaemolyticus (Bacteria)NANANANaturalNArFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2435NA

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V. harveyi and V. parahaemolyticus (Bacteria)NANANANaturalNArFmLC3Pattern recognition receptor (PRR)NANANANANANANANA290551892017NA
PRRID_2438NA

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S. cerevisiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCREP4C type Lectin (CTL/CLR)B. glabRataNANANANANANAtranscriptomic data290517622017NA
PRRID_2438NA

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S. cerevisiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCREP4C type Lectin (CTL/CLR)B. glabRataNANANANANANAtranscriptomic data290517622017NA
PRRID_2439NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)NaturalNAhyal-adherins (H-type)LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA290517622017NA
PRRID_2439NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)NaturalNAhyal-adherins (H-type)LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA290517622017NA
PRRID_2442NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCTL4C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX81.fastaB2FX81150NANA290517622017Pubchem_assay
PRRID_2442NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseCTL4C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX81.fastaB2FX81150NANA290517622017Pubchem_assay
PRRID_2443NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Damage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseCTLMA2C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX57.fastaB2FX57165NANA290517622017Pubchem_assay
PRRID_2443NA

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E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Damage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseCTLMA2C type Lectin (CTL/CLR)Anopheles gambiaeNANAB2FX57.fastaB2FX57165NANA290517622017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2448NA

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Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalInnate immunity elicitorEsSR-B1Scavenger receptor (SR)Eriocheir sinensisall tissue specially hemocytesClass B SRs are type III transmembrane receptors with two transmembrane domains,NANANAphagocytosis of invading bacteriaqRT-PCR289163592017NA
PRRID_2448NA

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Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalInnate immunity elicitorEsSR-B1Scavenger receptor (SR)Eriocheir sinensisall tissue specially hemocytesClass B SRs are type III transmembrane receptors with two transmembrane domains,NANANAphagocytosis of invading bacteriaqRT-PCR289163592017NA
PRRID_2449NA

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Vibrio anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorCgLRRIG-1Pattern recognition receptor (PRR)oyster Crassostrea gigasMuscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domainNANANAimmune effectors or pro-inflammatory factors as well as PRRs in oyster.PAMPs binding assay288890112017NA
PRRID_2449NA

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Vibrio anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorCgLRRIG-1Pattern recognition receptor (PRR)oyster Crassostrea gigasMuscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domainNANANAimmune effectors or pro-inflammatory factors as well as PRRs in oyster.PAMPs binding assay288890112017NA
PRRID_2450NA

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Vibrio anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorCgLRRIG-2Pattern recognition receptor (PRR)oyster Crassostrea gigasMuscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domainNANANAimmune effectors or pro-inflammatory factors as well as PRRs in oyster.PAMPs binding assay288890112017NA
PRRID_2450NA

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Vibrio anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorCgLRRIG-2Pattern recognition receptor (PRR)oyster Crassostrea gigasMuscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domainNANANAimmune effectors or pro-inflammatory factors as well as PRRs in oyster.PAMPs binding assay288890112017NA
PRRID_2455NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-4CfLRRop-4Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadssix LRR motifs plus one LRR_TYPNANANANANA288077242017NA
PRRID_2455NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-4CfLRRop-4Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadssix LRR motifs plus one LRR_TYPNANANANANA288077242017NA
PRRID_2456NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-5CfLRRop-5Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadsone LRRNT motif plus five LRR motifs,NANANANANA288077242017NA
PRRID_2456NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-5CfLRRop-5Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadsone LRRNT motif plus five LRR motifs,NANANANANA288077242017NA
PRRID_2457NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-6CfLRRop-6Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadsmerely three LRR motifsNANANANANA288077242017NA
PRRID_2457NA

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Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalStimulation of CfLRRop-6CfLRRop-6Pattern recognition receptor (PRR)Zhikong scallop Chlamys farrerihepatopancreas, gills and gonadsmerely three LRR motifsNANANANANA288077242017NA
PRRID_2459NA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)Bemisia tabaci (Gennadius)3rd nymphal instar.TIR domainNANANAMicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2459NA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)Bemisia tabaci (Gennadius)3rd nymphal instar.TIR domainNANANAMicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2460NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLR.CaNTCC type Lectin (CTL/CLR)Carassius auratusliver, spleen and head-kidneyCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2460NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalActivation of CLR.CaNTCC type Lectin (CTL/CLR)Carassius auratusliver, spleen and head-kidneyCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2461NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2461NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2462NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2462NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2463NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2463NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2464NA

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S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2464NA

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S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2465NA

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E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2465NA

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E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2472NA

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Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2472NA

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Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2473NA

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Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2473NA

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Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2477NA

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2477NA

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2478NA

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Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2478NA

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Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2479NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2479NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2480NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2480NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2481NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2481NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2482NA

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Haemophilus influenzae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2482NA

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Haemophilus influenzae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2483NA

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2483NA

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2494NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2494NA

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S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2530Pam2CS-type

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BacteriaCCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAimidazoquinolinesSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANAwestern blotting290498862017NA
PRRID_2530Pam2CS-type

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BacteriaCCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAimidazoquinolinesSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANAwestern blotting290498862017NA
PRRID_2531Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONANASyntheticanti- inflammatory activityToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2531Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONANASyntheticanti- inflammatory activityToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2538Peptidoglycan (PG) (Legionella recognized)

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BacteriaNANAProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2538Peptidoglycan (PG) (Legionella recognized)

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BacteriaNANAProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2539Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2539Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2541Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2541Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2543Peptidoglycan (PGN)

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P. gulae (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCauses inflammation and activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceHEK cellsNAQ8K3Z0.fastaQ8K3Z01020activate NF-κB.NA286300662017Pubchem_assay
PRRID_2543Peptidoglycan (PGN)

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P. gulae (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCauses inflammation and activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceHEK cellsNAQ8K3Z0.fastaQ8K3Z01020activate NF-κB.NA286300662017Pubchem_assay
PRRID_2544Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2544Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivation of CLRs.rCaNTCC type Lectin (CTL/CLR)Carassius auratusLiverCarbohydrate recognition domain (CRD)NANANApathogen recognition in Qihe 538 crucian carpMicrobial binding assay286026832017NA
PRRID_2545Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantBjLRPLow density lipoprotein receptor-related protein (LRP)B. japonicumgill, muscle, notochord and testisLY-EGF-CRD- EGF-CRDNANANAphagocytosis of apoptotic cellsqRT-PCR284002712017NA
PRRID_2545Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantBjLRPLow density lipoprotein receptor-related protein (LRP)B. japonicumgill, muscle, notochord and testisLY-EGF-CRD- EGF-CRDNANANAphagocytosis of apoptotic cellsqRT-PCR284002712017NA
PRRID_2546Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNArCgPGRPS4Pattern recognition receptor (PRR)NANANANANANANANA280420812017NA
PRRID_2546Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNArCgPGRPS4Pattern recognition receptor (PRR)NANANANANANANANA280420812017NA
PRRID_2547peptidoglycan (PGN)-derived muropeptides

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANucleotide-binding oligomerization domain 1Q9Y239.fastaQ9Y239953NANA290662552017Pubchem_assay
PRRID_2547peptidoglycan (PGN)-derived muropeptides

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANucleotide-binding oligomerization domain 1Q9Y239.fastaQ9Y239953NANA290662552017Pubchem_assay
PRRID_2550periplasmic flagella

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T. denticola (Bacteria)MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ349Pattern-associated molecular patterns (PAMPs)Naturalperiodontal inflammation;Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290848992017Pubchem_assay
PRRID_2550periplasmic flagella

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T. denticola (Bacteria)MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ349Pattern-associated molecular patterns (PAMPs)Naturalperiodontal inflammation;Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290848992017Pubchem_assay
PRRID_2551PG-derived molecules (iE-DAP and MDP respectively

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BacteriaN[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAProteinNaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2551PG-derived molecules (iE-DAP and MDP respectively

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BacteriaN[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAProteinNaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2552phosphatidyl-myo-inositol mannosides (PIM)

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2552phosphatidyl-myo-inositol mannosides (PIM)

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2553phosphatidyl-myo-inositol mannosides (PIM)

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_2553phosphatidyl-myo-inositol mannosides (PIM)

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_2558polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT])

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BacteriaCC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2558polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT])

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BacteriaCC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay