Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1218 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induction of the antiviral protein Mx | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | A8SZH4.fasta | A8SZH4 | 1074 | strong induction of IL-1b and IFN-a1 | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1218 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induction of the antiviral protein Mx | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | A8SZH4.fasta | A8SZH4 | 1074 | strong induction of IL-1b and IFN-a1 | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1293 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5M (TLR5M) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1293 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5M (TLR5M) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1294 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5s (TLR5s) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | predominanlty in liver | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1294 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5s (TLR5s) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | predominanlty in liver | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1457 | Long ds RNA Click for more detail | fugu (Takifugu rubripes) (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | NA | NA | Q2A132.fasta | Q2A132 | 971 | participate together with TLR3 in type I interferon production | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1457 | Long ds RNA Click for more detail | fugu (Takifugu rubripes) (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | NA | NA | Q2A132.fasta | Q2A132 | 971 | participate together with TLR3 in type I interferon production | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1502 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | NA | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1502 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | NA | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1503 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | Toll-like receptor 13 (TLR13) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | B5X405.fasta | B5X405 | 962 | NA | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1503 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | Toll-like receptor 13 (TLR13) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | B5X405.fasta | B5X405 | 962 | NA | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1586 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | M1ZMQ4.fasta | M1ZMQ4 | 913 | play a role in antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1586 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | M1ZMQ4.fasta | M1ZMQ4 | 913 | play a role in antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1587 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 22a1 (TLR22a1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | paralleled TLR3 up-regulation in virus- infected fish | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1587 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 22a1 (TLR22a1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | paralleled TLR3 up-regulation in virus- infected fish | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1588 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 22a2 (TLR22a2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | B5BM14.fasta | B5BM14 | 925 | paralleled TLR3 up-regulation in virus- infected fish | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1588 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx | Toll-like receptor 22a2 (TLR22a2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | B5BM14.fasta | B5BM14 | 925 | paralleled TLR3 up-regulation in virus- infected fish | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1657 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F0X6.fasta | S0F0X6 | 1063 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1657 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F0X6.fasta | S0F0X6 | 1063 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1658 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8a1 (TLR8a1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | NA | NA | NA | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1658 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8a1 (TLR8a1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | NA | NA | NA | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1659 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8a2 (TLR8a2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F0N4.fasta | S0F0N4 | 1035 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1659 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8a2 (TLR8a2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F0N4.fasta | S0F0N4 | 1035 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1660 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8b1 (TLR8b1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F1A6.fasta | S0F1A6 | 1034 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1660 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8b1 (TLR8b1) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F1A6.fasta | S0F1A6 | 1034 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1661 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8b2 (TLR8b2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F1D1.fasta | S0F1D1 | 1036 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1661 | type I interferons Click for more detail | Host (Endogenous) (others) | MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY | 175 | Protein | Natural | induces TLR7 and TLR 8 in salmon | Toll-like receptor 8b2 (TLR8b2) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill | NA | S0F1D1.fasta | S0F1D1 | 1036 | antiviral response in salmon | Real-time PCR | 24736205 | 2014 | Pubchem_assay |