PRRDB 2.0 :
Pattern Recognition Receptor Database
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C-Type Lectins (CTLs/CLRs)
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1,3-β-D-Glucan Pattern Recognition Protein(GRPs)
Lectins
Mannose Receptors (MRs)
Nod like Receptors (NLRs)
Peptidoglycan Recognition Proteins (PGRPs)
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Browse result page of PRRDB 2.0
PRRID
Name of Ligand
Source of ligand
Sequence of Ligand
Length of Ligand
Type of Ligand
Occurence
Role of Ligand
Name of Receptor
Type of Reeptor
Source of the Receptor
Localization
Domain
Sequence of Receptor
Swiss prot ID
Length of receptor
Function of Receptor
Assay used
PMID
Year of publication
Pubchem assay
PRRID_2660
Triacylated lipopeptides
Click for more detail
Bacteria
NA
NA
Lipopeptides
Natural
Induce IL-Ôòæ production in human tonsillar B cells
Toll-like receptor 1 (TLR1)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
Q15399.fasta
Q15399
786
NA
NA
29028369
2017
Pubchem_assay
PRRID_2660
Triacylated lipopeptides
Click for more detail
Bacteria
NA
NA
Lipopeptides
Natural
Induce IL-Ôòæ production in human tonsillar B cells
Toll-like receptor 1 (TLR1)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
Q15399.fasta
Q15399
786
NA
NA
29028369
2017
Pubchem_assay
PRRID_2663
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
Nucleic Acid
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
NA
NA
29263932
2017
Pubchem_assay
PRRID_2663
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
Nucleic Acid
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
NA
NA
29263932
2017
Pubchem_assay
PRRID_2664
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
NA
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
NA
NA
Q9NR96.fasta
Q9NR96
1032
NA
NA
29066255
2017
Pubchem_assay
PRRID_2664
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
NA
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
NA
NA
Q9NR96.fasta
Q9NR96
1032
NA
NA
29066255
2017
Pubchem_assay
PRRID_2666
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
NA
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
NA
NA
29028369
2017
Pubchem_assay
PRRID_2666
Unmethylated CpG DNA
Click for more detail
Bacteria
NA
NA
NA
Natural
NA
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
NA
NA
29028369
2017
Pubchem_assay
PRRID_2673
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.
Nod-like receptor P3 (NLRP3)
NOD-like receptor (NLR)
Human
Brain
NA
Q96P20.fasta
Q96P20
1036
protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits
NA
28801521
2017
Pubchem_assay
PRRID_2673
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.
Nod-like receptor P3 (NLRP3)
NOD-like receptor (NLR)
Human
Brain
NA
Q96P20.fasta
Q96P20
1036
protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits
NA
28801521
2017
Pubchem_assay
PRRID_2678
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
Monocyte
Leucine-rich Repeat (LRR) Domain
O60603.fasta
O60603
784
NA
NA
28961019
2017
Pubchem_assay
PRRID_2678
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
Monocyte
Leucine-rich Repeat (LRR) Domain
O60603.fasta
O60603
784
NA
NA
28961019
2017
Pubchem_assay
PRRID_2679
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.
NA
Toll-like receptor (TLR)
Human
Monocyte
Leucine-rich Repeat (LRR) Domain
O00206.fasta
O00206
839
NA
NA
28961019
2017
Pubchem_assay
PRRID_2679
Uric acid
Click for more detail
NA
C12=C(NC(=O)N1)NC(=O)NC2=O
NA
Damage-associated molecular patterns (DAMPs)
Natural
Induce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.
NA
Toll-like receptor (TLR)
Human
Monocyte
Leucine-rich Repeat (LRR) Domain
O00206.fasta
O00206
839
NA
NA
28961019
2017
Pubchem_assay
PRRID_2680
Uropathogenic E. coli
Click for more detail
E. coli(Bacteria)
NA
NA
NA
Natural
NA
Toll-like receptor 10 (TLR10)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
NA
NA
29263932
2017
NA
PRRID_2680
Uropathogenic E. coli
Click for more detail
E. coli(Bacteria)
NA
NA
NA
Natural
NA
Toll-like receptor 10 (TLR10)
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
NA
NA
29263932
2017
NA
PRRID_2682
various glycans
Click for more detail
NA
NA
NA
NA
Natural
NA
MBL2
Pattern recognition receptor (PRR)
Human
NA
soluble mannose-binding lectin or mannose-binding protein
P11226.fasta
P11226
248
NA
NA
29066255
2017
Pubchem_assay
PRRID_2682
various glycans
Click for more detail
NA
NA
NA
NA
Natural
NA
MBL2
Pattern recognition receptor (PRR)
Human
NA
soluble mannose-binding lectin or mannose-binding protein
P11226.fasta
P11226
248
NA
NA
29066255
2017
Pubchem_assay
PRRID_2689
Viral RNA
Click for more detail
RSV, IAV, and HCMV (virus)
NA
NA
Nucleic Acid
Natural
Likely tetramerization into washer- locker structure
Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)
NOD-like receptor (NLR)
Human
Cytoplasm. Macrophages, monocytes, Paneth cells, DCs
NA
Q9HC29.fasta
Q9HC29
1040
NA
NA
28374903
2017
Pubchem_assay
PRRID_2689
Viral RNA
Click for more detail
RSV, IAV, and HCMV (virus)
NA
NA
Nucleic Acid
Natural
Likely tetramerization into washer- locker structure
Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)
NOD-like receptor (NLR)
Human
Cytoplasm. Macrophages, monocytes, Paneth cells, DCs
NA
Q9HC29.fasta
Q9HC29
1040
NA
NA
28374903
2017
Pubchem_assay
PRRID_2690
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
IFIH1 (MDA5)
Intracellular associated Pattern recognition receptor (PRR)
Human
NA
helicase C domain 1, RIG-1-like receptor family,
Q9BYX4.fasta
Q9BYX4
1025
NA
NA
29066255
2017
Pubchem_assay
PRRID_2690
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
IFIH1 (MDA5)
Intracellular associated Pattern recognition receptor (PRR)
Human
NA
helicase C domain 1, RIG-1-like receptor family,
Q9BYX4.fasta
Q9BYX4
1025
NA
NA
29066255
2017
Pubchem_assay
PRRID_2691
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
LGP2 (DEXH58)
Intracellular associated Pattern recognition receptor (PRR)
Human
NA
DEXH (Asp-Glu-X-His) Box Polypeptide 58, RIG-1-like receptor family,
NA
NA
NA
NA
NA
29066255
2017
NA
PRRID_2691
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
LGP2 (DEXH58)
Intracellular associated Pattern recognition receptor (PRR)
Human
NA
DEXH (Asp-Glu-X-His) Box Polypeptide 58, RIG-1-like receptor family,
NA
NA
NA
NA
NA
29066255
2017
NA
PRRID_2692
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
RIG-1 (DDX58)
Rig-like receptor (RLR)
Human
NA
RIG-1-like receptor family
O95786.fasta
O95786
925
NA
NA
29066255
2017
Pubchem_assay
PRRID_2692
Viral sensor
Click for more detail
Virus
NA
NA
NA
Natural
NA
RIG-1 (DDX58)
Rig-like receptor (RLR)
Human
NA
RIG-1-like receptor family
O95786.fasta
O95786
925
NA
NA
29066255
2017
Pubchem_assay
PRRID_2693
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 3 (TLR3)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
O15455.fasta
O15455
904
NA
NA
29263932
2017
Pubchem_assay
PRRID_2693
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 3 (TLR3)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
O15455.fasta
O15455
904
NA
NA
29263932
2017
Pubchem_assay
PRRID_2694
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 7 (TLR7)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NYK1.fasta
Q9NYK1
1049
NA
NA
29263932
2017
Pubchem_assay
PRRID_2694
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 7 (TLR7)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NYK1.fasta
Q9NYK1
1049
NA
NA
29263932
2017
Pubchem_assay
PRRID_2695
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 8 (TLR8)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NR97.fasta
Q9NR97
1041
NA
NA
29263932
2017
Pubchem_assay
PRRID_2695
Viruses or bacteria
Click for more detail
Virus, Bacteria
NA
NA
Pattern-associated molecular patterns (PAMPs)
Natural
NA
Toll-like receptor 8 (TLR8)
Toll-like receptor (TLR)
Human
cytoplasm
Leucine-rich Repeat (LRR) Domain
Q9NR97.fasta
Q9NR97
1041
NA
NA
29263932
2017
Pubchem_assay
PRRID_2699
β­glucan
Click for more detail
Fungi
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Protein
Natural
NA
Nod-like receptor P3 (NLRP3)
NOD-like receptor (NLR)
Human
human peripheral B­lymphocytes
NA
Q96P20.fasta
Q96P20
1036
NA
NA
29170665
2017
Pubchem_assay
PRRID_2699
β­glucan
Click for more detail
Fungi
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Protein
Natural
NA
Nod-like receptor P3 (NLRP3)
NOD-like receptor (NLR)
Human
human peripheral B­lymphocytes
NA
Q96P20.fasta
Q96P20
1036
NA
NA
29170665
2017
Pubchem_assay
PRRID_2703
Fungal chitin
Click for more detail
Candida albicans(fungi)
NA
NA
NA
Natural
NA
CARD9
NOD-like receptor (NLR)
Human
myeloid cells,
Caspase Recruitment Domain
Q9H257.fasta
Q9H257
536
NA
Invasive CNS candidiasis
29307770
2018
Pubchem_assay
PRRID_2703
Fungal chitin
Click for more detail
Candida albicans(fungi)
NA
NA
NA
Natural
NA
CARD9
NOD-like receptor (NLR)
Human
myeloid cells,
Caspase Recruitment Domain
Q9H257.fasta
Q9H257
536
NA
Invasive CNS candidiasis
29307770
2018
Pubchem_assay
PRRID_2710
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)
NOD-like receptor (NLR)
Human
cytoplasm
CARD
Q9Y239.fasta
Q9Y239
953
NA
NA
29353310
2018
Pubchem_assay
PRRID_2710
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)
NOD-like receptor (NLR)
Human
cytoplasm
CARD
Q9Y239.fasta
Q9Y239
953
NA
NA
29353310
2018
Pubchem_assay
PRRID_2711
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q9HC29.fasta
Q9HC29
1040
NA
NA
29353310
2018
Pubchem_assay
PRRID_2711
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q9HC29.fasta
Q9HC29
1040
NA
NA
29353310
2018
Pubchem_assay
PRRID_2712
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
CIITA
NOD-like receptor (NLR)
Human
Nucleus
NA
P33076.fasta
P33076
1130
NA
NA
29353310
2018
Pubchem_assay
PRRID_2712
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
CIITA
NOD-like receptor (NLR)
Human
Nucleus
NA
P33076.fasta
P33076
1130
NA
NA
29353310
2018
Pubchem_assay
PRRID_2713
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nod-like receptor C3 (NLRC3)
NOD-like receptor (NLR)
Human
cytoplasm
Untypical CARD
Q7RTR2.fasta
Q7RTR2
1065
NA
NA
29353310
2018
Pubchem_assay
PRRID_2713
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nod-like receptor C3 (NLRC3)
NOD-like receptor (NLR)
Human
cytoplasm
Untypical CARD
Q7RTR2.fasta
Q7RTR2
1065
NA
NA
29353310
2018
Pubchem_assay
PRRID_2714
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nod-like receptor C4 (NLRC4)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q9NPP4.fasta
Q9NPP4
1024
NA
NA
29353310
2018
Pubchem_assay
PRRID_2714
NA
Click for more detail
NA
NA
NA
NA
Natural
NA
Nod-like receptor C4 (NLRC4)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q9NPP4.fasta
Q9NPP4
1024
NA
NA
29353310
2018
Pubchem_assay
PRRID_2715
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor 5 (NLR5)
NOD-like receptor (NLR)
Human
Nucleus
NA
Q86WI3.fasta
Q86WI3
1866
NA
NA
29353310
2018
Pubchem_assay
PRRID_2715
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor 5 (NLR5)
NOD-like receptor (NLR)
Human
Nucleus
NA
Q86WI3.fasta
Q86WI3
1866
NA
NA
29353310
2018
Pubchem_assay
PRRID_2716
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 1 (NLRP1)
NOD-like receptor (NLR)
Human
cytoplasm
Pyrin
Q9C000.fasta
Q9C000
1473
NA
NA
29353310
2018
Pubchem_assay
PRRID_2716
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 1 (NLRP1)
NOD-like receptor (NLR)
Human
cytoplasm
Pyrin
Q9C000.fasta
Q9C000
1473
NA
NA
29353310
2018
Pubchem_assay
PRRID_2717
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 4 (NLRP4)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q96MN2.fasta
Q96MN2
994
NA
NA
29353310
2018
Pubchem_assay
PRRID_2717
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 4 (NLRP4)
NOD-like receptor (NLR)
Human
cytoplasm
NA
Q96MN2.fasta
Q96MN2
994
NA
NA
29353310
2018
Pubchem_assay
PRRID_2718
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 5 (NLRP5)
NOD-like receptor (NLR)
Human
cytoplasm
NA
P59047.fasta
P59047
1200
NA
NA
29353310
2018
Pubchem_assay
PRRID_2718
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 5 (NLRP5)
NOD-like receptor (NLR)
Human
cytoplasm
NA
P59047.fasta
P59047
1200
NA
NA
29353310
2018
Pubchem_assay
PRRID_2719
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 6 (NLRP6)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
P59044.fasta
P59044
892
NA
NA
29353310
2018
Pubchem_assay
PRRID_2719
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor protein 6 (NLRP6)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
P59044.fasta
P59044
892
NA
NA
29353310
2018
Pubchem_assay
PRRID_2720
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor 7 (NLRP7)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q8WX94.fasta
Q8WX94
980
NA
NA
29353310
2018
Pubchem_assay
PRRID_2720
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor 7 (NLRP7)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q8WX94.fasta
Q8WX94
980
NA
NA
29353310
2018
Pubchem_assay
PRRID_2721
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor P8 (NLRP8)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q86W28.fasta
Q86W28
1048
NA
NA
29353310
2018
Pubchem_assay
PRRID_2721
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor P8 (NLRP8)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q86W28.fasta
Q86W28
1048
NA
NA
29353310
2018
Pubchem_assay
PRRID_2722
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor P9 (NLRP9)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q7RTR0.fasta
Q7RTR0
991
NA
NA
29353310
2018
Pubchem_assay
PRRID_2722
NA
Click for more detail
NA
NA
NA
NA
NA
NA
Nod-like receptor P9 (NLRP9)
NOD-like receptor (NLR)
Human
Cytoplasm
NA
Q7RTR0.fasta
Q7RTR0
991
NA
NA
29353310
2018
Pubchem_assay