Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2393NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanbroncheolavage and blood cells( monocytes)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2393NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanbroncheolavage and blood cells( monocytes)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2394NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2394NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2395NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanPrimary human corneal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NAImmunofluorescence293306752017Pubchem_assay
PRRID_2395NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanPrimary human corneal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NAImmunofluorescence293306752017Pubchem_assay
PRRID_2396NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2396NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2397NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2397NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2398NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2398NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2399NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2399NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2400NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2400NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2401NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2401NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2402NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2402NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2403NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanbasal layer of epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2403NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanbasal layer of epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2404NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs2107538*CCL5C-C motif chemokine ligand 5HumanNANANANANANANA292536102017NA
PRRID_2404NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs2107538*CCL5C-C motif chemokine ligand 5HumanNANANANANANANA292536102017NA
PRRID_2405NA

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rhinovirus (virus)NANANANAsevere RSV bronchiolitisrs1060826*NOS2NAHumanNANANANANANANA292536102017NA
PRRID_2405NA

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rhinovirus (virus)NANANANAsevere RSV bronchiolitisrs1060826*NOS2NAHumanNANANANANANANA292536102017NA
PRRID_2406NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs4986790*Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2406NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs4986790*Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2407NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292536102017Pubchem_assay
PRRID_2407NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292536102017Pubchem_assay
PRRID_2408NA

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Respiratory syncytial virus (virus) NANANANAsignificantly increased the risk of RSV bronchiolitisrs2228570*VDRVitamin D receptior (VDR)HumanNANANANANANANA292536102017NA
PRRID_2408NA

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Respiratory syncytial virus (virus) NANANANAsignificantly increased the risk of RSV bronchiolitisrs2228570*VDRVitamin D receptior (VDR)HumanNANANANANANANA292536102017NA
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2412NA

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H. pylori (Bacteria)NANANANaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291350542017Pubchem_assay
PRRID_2412NA

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H. pylori (Bacteria)NANANANaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291350542017Pubchem_assay
PRRID_2413NA

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NANANANANANANAIP (BIRC1)Intracellular associated Pattern recognition receptor (PRR)HumanNABaculoviral IAP repeat-containing protein 1Q13075.fastaQ130751403NANA290662552017Pubchem_assay
PRRID_2413NA

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NANANANANANANAIP (BIRC1)Intracellular associated Pattern recognition receptor (PRR)HumanNABaculoviral IAP repeat-containing protein 1Q13075.fastaQ130751403NANA290662552017Pubchem_assay
PRRID_2414NA

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NANANANANANANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)HumanNANLR family CARD domain-containing protein 4,Q9NPP4.fastaQ9NPP41024NANA290662552017Pubchem_assay
PRRID_2414NA

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NANANANANANANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)HumanNANLR family CARD domain-containing protein 4,Q9NPP4.fastaQ9NPP41024NANA290662552017Pubchem_assay
PRRID_2415NA

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NANANANANaturalNAPTX3Pattern recognition receptor (PRR)HumanNANAP26022.fastaP26022381NANA290662552017Pubchem_assay
PRRID_2415NA

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NANANANANaturalNAPTX3Pattern recognition receptor (PRR)HumanNANAP26022.fastaP26022381NANA290662552017Pubchem_assay
PRRID_2416NA

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NANANANANANAPTX4Pattern recognition receptor (PRR)HumanNANAQ96A99.fastaQ96A99478NANA290662552017Pubchem_assay
PRRID_2416NA

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NANANANANANAPTX4Pattern recognition receptor (PRR)HumanNANAQ96A99.fastaQ96A99478NANA290662552017Pubchem_assay
PRRID_2417NA

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NANANANANANASAA1Pattern recognition receptor (PRR)HumanNANAP0DJI8.fastaP0DJI8122NANA290662552017Pubchem_assay
PRRID_2417NA

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NANANANANANASAA1Pattern recognition receptor (PRR)HumanNANAP0DJI8.fastaP0DJI8122NANA290662552017Pubchem_assay
PRRID_2418NA

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NANANANANANACD209 (DC-SIGN)Pattern recognition receptor (PRR)HumanNANAQ9NNX6.fastaQ9NNX6404NANA290662552017Pubchem_assay
PRRID_2418NA

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NANANANANANACD209 (DC-SIGN)Pattern recognition receptor (PRR)HumanNANAQ9NNX6.fastaQ9NNX6404NANA290662552017Pubchem_assay
PRRID_2419NA

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VirusNANANANaturalNACLEC4M (L-SIGN)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ9H2X3.fastaQ9H2X3399NANA290662552017Pubchem_assay
PRRID_2419NA

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VirusNANANANaturalNACLEC4M (L-SIGN)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ9H2X3.fastaQ9H2X3399NANA290662552017Pubchem_assay
PRRID_2420NA

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Gram-positive, Gram-negative bacteria and yeastNANANANaturalNACOLEC12Scavenger receptor (SR)HumanNACollectin Sub-Family Member 12,Q5KU26.fastaQ5KU26742NANA290662552017Pubchem_assay
PRRID_2420NA

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Gram-positive, Gram-negative bacteria and yeastNANANANaturalNACOLEC12Scavenger receptor (SR)HumanNACollectin Sub-Family Member 12,Q5KU26.fastaQ5KU26742NANA290662552017Pubchem_assay
PRRID_2421NA

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S. typhimurium (Bacteria)NANANANaturalNAFCN2Pattern recognition receptor (PRR)HumanNAFicolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin),Q15485.fastaQ15485313NANA290662552017Pubchem_assay
PRRID_2421NA

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S. typhimurium (Bacteria)NANANANaturalNAFCN2Pattern recognition receptor (PRR)HumanNAFicolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin),Q15485.fastaQ15485313NANA290662552017Pubchem_assay
PRRID_2422NA

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NANANANANANAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanNANAQ9UEW3.fastaQ9UEW3520NANA290662552017Pubchem_assay
PRRID_2422NA

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NANANANANANAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanNANAQ9UEW3.fastaQ9UEW3520NANA290662552017Pubchem_assay
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2437NA

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CA16(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2437NA

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CA16(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2481NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2481NA

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M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2492NA

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 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2492NA

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 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2495 non-lipopeptidic PAMPs

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2495 non-lipopeptidic PAMPs

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2501Nigericin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2501Nigericin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2521ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2521ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2524ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2524ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2527P2Y2PalIC2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2527P2Y2PalIC2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2528P2Y2PalIC3

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2528P2Y2PalIC3

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2529Palmitic acid

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NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2529Palmitic acid

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NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2531Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONANASyntheticanti- inflammatory activityToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2531Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONANASyntheticanti- inflammatory activityToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2533pathogen ssRNA

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flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2533pathogen ssRNA

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flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2540Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIncreased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman embryonic kidney 293 (HERK 293 ) cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2540Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIncreased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman embryonic kidney 293 (HERK 293 ) cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2547peptidoglycan (PGN)-derived muropeptides

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANucleotide-binding oligomerization domain 1Q9Y239.fastaQ9Y239953NANA290662552017Pubchem_assay
PRRID_2547peptidoglycan (PGN)-derived muropeptides

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANucleotide-binding oligomerization domain 1Q9Y239.fastaQ9Y239953NANA290662552017Pubchem_assay
PRRID_2548IRS 945

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NANANANucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2548IRS 945

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NANANANucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay