Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2625	single-stranded RNA Click for more detail	Parainfluenza (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2625	single-stranded RNA Click for more detail	Parainfluenza (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2626	single-stranded RNA Click for more detail	Influenza A (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2626	single-stranded RNA Click for more detail	Influenza A (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2640	Synthetic trehalose diesters including TDB Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2640	Synthetic trehalose diesters including TDB Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2641	Synthetic trehalose diesters including corynomycolates Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2641	Synthetic trehalose diesters including corynomycolates Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2644	Taxol Click for more detail	NA	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Enhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2644	Taxol Click for more detail	NA	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Enhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2645	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mcl (Clec4d)	Syk-coupled CLR	Mice	NA	NA	Q9Z2H6.fasta	Q9Z2H6	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2645	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mcl (Clec4d)	Syk-coupled CLR	Mice	NA	NA	Q9Z2H6.fasta	Q9Z2H6	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2647	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2647	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2650	Teneligliptin Click for more detail	NA	CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5	NA	DPP4 inhibitor	Natural	anti- inflammatory activity	cav-1	Pattern recognition receptor (PRR)	Mice	Macrophages	Leucine-rich Repeat (LRR) Domain	P49817.fasta	P49817	178	NA	NA	29113797	2017	Pubchem_assay
PRRID_2650	Teneligliptin Click for more detail	NA	CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5	NA	DPP4 inhibitor	Natural	anti- inflammatory activity	cav-1	Pattern recognition receptor (PRR)	Mice	Macrophages	Leucine-rich Repeat (LRR) Domain	P49817.fasta	P49817	178	NA	NA	29113797	2017	Pubchem_assay
PRRID_2667	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29028369	2017	Pubchem_assay
PRRID_2667	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29028369	2017	Pubchem_assay
PRRID_2671	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_2671	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_2672	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2672	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2675	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_2675	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_2676	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9QUK7	511	NA	NA	28961019	2017	Pubchem_assay
PRRID_2676	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9QUK7	511	NA	NA	28961019	2017	Pubchem_assay
PRRID_2677	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUN6.fasta	Q9QUK6	835	NA	NA	28961019	2017	Pubchem_assay
PRRID_2677	Uric acid Click for more detail	NA	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the synthesis of IL-1Œ≤, TNF-Œ± and TGF-Œ≤ by murine macrophages.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUN6.fasta	Q9QUK6	835	NA	NA	28961019	2017	Pubchem_assay
PRRID_2696	Zymosan Click for more detail	Fungi(Yeast)	NA	NA	Glucan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2696	Zymosan Click for more detail	Fungi(Yeast)	NA	NA	Glucan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2701	CBLB502 Click for more detail	NA	NA	NA	NA	Synthetic	alleviate bone marrow and intestinal injuries	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	NA	NA	29364499	2018	Pubchem_assay
PRRID_2701	CBLB502 Click for more detail	NA	NA	NA	NA	Synthetic	alleviate bone marrow and intestinal injuries	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	NA	NA	29364499	2018	Pubchem_assay
PRRID_2737	Œ≤-galactosides Click for more detail	Leishmania major (others)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	cutaneous and visceral leishmaniasis	Gal-3	Pattern recognition receptor (PRR)	Mice	lymph nodes and higher parasite load in the footpads	carbohydrate recognition domain	Q9JHE4 .fasta	Q9JHE4	423	via modulation of the Notch signaling pathway	NA	28986248	2018	Pubchem_assay
PRRID_2737	Œ≤-galactosides Click for more detail	Leishmania major (others)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	cutaneous and visceral leishmaniasis	Gal-3	Pattern recognition receptor (PRR)	Mice	lymph nodes and higher parasite load in the footpads	carbohydrate recognition domain	Q9JHE4 .fasta	Q9JHE4	423	via modulation of the Notch signaling pathway	NA	28986248	2018	Pubchem_assay

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