Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1683Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1683Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1685Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1685Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1693CpG-ODN 1826

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NA5’-tccatgacgttcctgacgtt-3’20Nucleic AcidSyntheticTLR9 stimulation induces apoptosis of neurons via SARM1 signalling pathwayToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MicePrimary cortical neuronsNAQ9NR96.fastaQ9NR961032It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.MTT assay264231492015Pubchem_assay
PRRID_1693CpG-ODN 1826

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NA5’-tccatgacgttcctgacgtt-3’20Nucleic AcidSyntheticTLR9 stimulation induces apoptosis of neurons via SARM1 signalling pathwayToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MicePrimary cortical neuronsNAQ9NR96.fastaQ9NR961032It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.MTT assay264231492015Pubchem_assay
PRRID_1696Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticTLR7 stimulation induces apoptosis of neurons via SARM1 signalling pathwayToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MicePrimary cortical neuronsNAP58681.fastaP586811050It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.MTT assay264231492015Pubchem_assay
PRRID_1696Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticTLR7 stimulation induces apoptosis of neurons via SARM1 signalling pathwayToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MicePrimary cortical neuronsNAP58681.fastaP586811050It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.MTT assay264231492015Pubchem_assay
PRRID_1702Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_1702Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_1708Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalimmunostimulantToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)Mice (Murine)NANANANANAControversial (induce or inhibit)NA271202222016NA
PRRID_1708Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalimmunostimulantToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)Mice (Murine)NANANANANAControversial (induce or inhibit)NA271202222016NA
PRRID_1709Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Controversial (induce or inhibit)NA271202222016Pubchem_assay
PRRID_1709Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Controversial (induce or inhibit)NA271202222016Pubchem_assay
PRRID_1710Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)Mice (Murine)NANANANANAattenuates asthmaNA271202222016NA
PRRID_1710Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)Mice (Murine)NANANANANAattenuates asthmaNA271202222016NA
PRRID_1711Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)Mice (Murine)NANANANANAAttenuate or inhibitNA271202222016NA
PRRID_1711Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)Mice (Murine)NANANANANAAttenuate or inhibitNA271202222016NA
PRRID_1712Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalimmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NANAQ9NR96.fastaQ9NR961032Attenuate or inhibitNA271202222016Pubchem_assay
PRRID_1712Agonist

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NANANAPattern-associated molecular patterns (PAMPs)NaturalimmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NANAQ9NR96.fastaQ9NR961032Attenuate or inhibitNA271202222016Pubchem_assay
PRRID_1713Agonist

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalControversial (induce or inhibit)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)Mice (Murine)NANANANANAExpansion of Tregs in OVA-induced asthma modelNA271202222016NA
PRRID_1713Agonist

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalControversial (induce or inhibit)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)Mice (Murine)NANANANANAExpansion of Tregs in OVA-induced asthma modelNA271202222016NA
PRRID_1714Agonist

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905NFκB↑NA271202222016Pubchem_assay
PRRID_1714Agonist

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905NFκB↑NA271202222016Pubchem_assay
PRRID_1717Bacterial 23S ribosomal RNA

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BacteriaGGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA2905Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5N8.fastaQ6R5N8991Activate NF-KBNA277566042016Pubchem_assay
PRRID_1717Bacterial 23S ribosomal RNA

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BacteriaGGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA2905Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5N8.fastaQ6R5N8991Activate NF-KBNA277566042016Pubchem_assay
PRRID_1718BpA

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Activation of caspase1NA271202222016Pubchem_assay
PRRID_1718BpA

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Activation of caspase1NA271202222016Pubchem_assay
PRRID_1719BpA

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Brugia pahangi(others)TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG140Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micelymphatic vesselsNAQ9QUK6.fastaQ9QUK6835Activation of caspaseÔòªNA271202222016Pubchem_assay
PRRID_1719BpA

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Brugia pahangi(others)TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG140Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micelymphatic vesselsNAQ9QUK6.fastaQ9QUK6835Activation of caspaseÔòªNA271202222016Pubchem_assay
PRRID_1721cathepsin cysteine

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S. mansoni (others)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Activate STAT1NA271202222016Pubchem_assay
PRRID_1721cathepsin cysteine

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S. mansoni (others)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Activate STAT1NA271202222016Pubchem_assay
PRRID_1722cathepsin cysteine

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Schistosoma mansoni, Fasciola hepatica (Bacteria)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1722cathepsin cysteine

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Schistosoma mansoni, Fasciola hepatica (Bacteria)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1729dsDNA

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S. mansoni (others)NANANucleic AcidNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of TregsNA271202222016Pubchem_assay
PRRID_1729dsDNA

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S. mansoni (others)NANANucleic AcidNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of TregsNA271202222016Pubchem_assay
PRRID_1730dsDNA

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S. mansoni (others)NANANucleic AcidNaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905TLR2-dependent induction of Tregs Activate STATÔõúNA271202222016Pubchem_assay
PRRID_1730dsDNA

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S. mansoni (others)NANANucleic AcidNaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905TLR2-dependent induction of Tregs Activate STATÔõúNA271202222016Pubchem_assay
PRRID_1731ES-62

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835ERK‚Üë, P38 or JNKNA271202222016Pubchem_assay
PRRID_1731ES-62

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835ERK‚Üë, P38 or JNKNA271202222016Pubchem_assay
PRRID_1732ES-62

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceAcanthocheilonema viteae/lymphatic tissueNAQ9QUK6.fastaQ9QUK6835ERK↑, P38 or JNK MAP↓, Transient NFκB, Block mast cell degranulationNA271202222016Pubchem_assay
PRRID_1732ES-62

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceAcanthocheilonema viteae/lymphatic tissueNAQ9QUK6.fastaQ9QUK6835ERK↑, P38 or JNK MAP↓, Transient NFκB, Block mast cell degranulationNA271202222016Pubchem_assay
PRRID_1734Fag

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Setaria Digitata (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceabdominal cavityNAQ9QUK6.fastaQ9QUK6835Inhibits LPS mediated classical activationNA271202222016Pubchem_assay
PRRID_1734Fag

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Setaria Digitata (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceabdominal cavityNAQ9QUK6.fastaQ9QUK6835Inhibits LPS mediated classical activationNA271202222016Pubchem_assay
PRRID_1736FhHDM-1

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceFasciola hepatica/LiverNAQ9QUK6.fastaQ9QUK6835Binding to LPS and inhibits signalingNA271202222016Pubchem_assay
PRRID_1736FhHDM-1

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceFasciola hepatica/LiverNAQ9QUK6.fastaQ9QUK6835Binding to LPS and inhibits signalingNA271202222016Pubchem_assay
PRRID_1737Flagellin

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Salmonella (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1737Flagellin

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Salmonella (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1738Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9JLF7.fastaQ9JLF7859nuclear factor NF- κB mobilization and the stimulation and secretion of cytokines.NA277566042016Pubchem_assay
PRRID_1738Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9JLF7.fastaQ9JLF7859nuclear factor NF- κB mobilization and the stimulation and secretion of cytokines.NA277566042016Pubchem_assay
PRRID_1740Flagellin

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NAMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)NANAQ9JLF7.fastaQ9JLF7859induce asthmaNA271202222016Pubchem_assay
PRRID_1740Flagellin

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NAMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)NANAQ9JLF7.fastaQ9JLF7859induce asthmaNA271202222016Pubchem_assay
PRRID_1749HDM

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Helminths (others)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1749HDM

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Helminths (others)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1750HDM

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Schistosoma mansoni, Fasciola hepatica (Bacteria)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1750HDM

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Schistosoma mansoni, Fasciola hepatica (Bacteria)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1751Heat shock protein

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O. tsutsugamushi (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF572Pattern-associated molecular patterns (PAMPs)NaturalCause Scrub typhus, immunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceHEK293 cellsTIR domainQ9QUN7.fastaQ9QUN7784secretion of TNF-α and IL-6 by dendritic cellsELISA276207202016Pubchem_assay
PRRID_1751Heat shock protein

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O. tsutsugamushi (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF572Pattern-associated molecular patterns (PAMPs)NaturalCause Scrub typhus, immunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceHEK293 cellsTIR domainQ9QUN7.fastaQ9QUN7784secretion of TNF-α and IL-6 by dendritic cellsELISA276207202016Pubchem_assay
PRRID_1760lipophosphoglycans (LPG)

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Leishmania infantum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses visceral and cutaneous leishmaniasis, immunomodulatoryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activate MAPKs and the NF-κB inhibitor p-IκBα,NA275089302016Pubchem_assay
PRRID_1760lipophosphoglycans (LPG)

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Leishmania infantum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses visceral and cutaneous leishmaniasis, immunomodulatoryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activate MAPKs and the NF-κB inhibitor p-IκBα,NA275089302016Pubchem_assay
PRRID_1761lipophosphoglycans (LPG)

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Leishmania braziliensis (others)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses visceral and cutaneous leishmaniasis, immunomodulatoryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activate MAPKs and the NF-κB inhibitor p-IκBα,NA275089302016Pubchem_assay
PRRID_1761lipophosphoglycans (LPG)

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Leishmania braziliensis (others)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses visceral and cutaneous leishmaniasis, immunomodulatoryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activate MAPKs and the NF-κB inhibitor p-IκBα,NA275089302016Pubchem_assay
PRRID_1795LNFPlll

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)blood vessels(human and mice)NAQ9QUK6.fastaQ9QUK6835NFκB↑NA271202222016Pubchem_assay
PRRID_1795LNFPlll

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)blood vessels(human and mice)NAQ9QUK6.fastaQ9QUK6835NFκB↑NA271202222016Pubchem_assay
PRRID_1798LPS (HDM and fungal allergens)

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NACCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Controversial (induce or inhibit)NA271202222016Pubchem_assay
PRRID_1798LPS (HDM and fungal allergens)

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NACCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Controversial (induce or inhibit)NA271202222016Pubchem_assay
PRRID_1799Lyso-PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784NDNA271202222016Pubchem_assay
PRRID_1799Lyso-PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784NDNA271202222016Pubchem_assay
PRRID_1800Lyso-PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784NDNA271202222016Pubchem_assay
PRRID_1800Lyso-PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784NDNA271202222016Pubchem_assay
PRRID_1810NA

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Propionibacterium acnes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalrole in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-κB pathwayToll-like receptor 2 (TLR2)homodimersToll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainNANANAinduced NF-κB and AP-1activationELISA280249242016NA
PRRID_1810NA

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Propionibacterium acnes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalrole in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-κB pathwayToll-like receptor 2 (TLR2)homodimersToll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainNANANAinduced NF-κB and AP-1activationELISA280249242016NA
PRRID_1815NA

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Uropathogenic E.coli (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micebladder epithelial cellsextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1815NA

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Uropathogenic E.coli (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micebladder epithelial cellsextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1854Proteases

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1854Proteases

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1855PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1855PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1856PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1856PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1857PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1857PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1858PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1858PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1859pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4ÔòºNA271202222016Pubchem_assay
PRRID_1859pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4ÔòºNA271202222016Pubchem_assay
PRRID_1860pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependentNA271202222016Pubchem_assay
PRRID_1860pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependentNA271202222016Pubchem_assay
PRRID_1862rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üë Treg via TLR2 dependentNA271202222016Pubchem_assay
PRRID_1862rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üë Treg via TLR2 dependentNA271202222016Pubchem_assay
PRRID_1863rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üë Treg viaNA271202222016Pubchem_assay
PRRID_1863rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üë Treg viaNA271202222016Pubchem_assay
PRRID_1865SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1865SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1866SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4NA271202222016Pubchem_assay
PRRID_1866SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4NA271202222016Pubchem_assay
PRRID_1869SJMHEÔõú

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathway TLRÔò∫-dependentNA271202222016Pubchem_assay
PRRID_1869SJMHEÔõú

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathway TLRÔò∫-dependentNA271202222016Pubchem_assay
PRRID_1870SJMHEÔõú

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Schistosoma japonicum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathwayNA271202222016Pubchem_assay
PRRID_1870SJMHEÔõú

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Schistosoma japonicum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathwayNA271202222016Pubchem_assay