This page gives the option to the users to download the PDF files of the articles related to anticancer peptides which are available in Pubmed Central as open access.
| Title | |
|---|---|
| Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. | Download |
| Apolipoprotein E Peptide-Guided Disulfide-Cross-Linked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma. | Download |
| A dimeric thymosin beta 4 with novel bio-activity protects post-ischemic cardiac function by accelerating vascular endothelial cell proliferation. | Download |
| Pharmacological, Pharmacokinetic, Pharmacodynamic and Physicochemical Characterization of FE 205030: A Potent, Fast Acting, Injectable CGRP Receptor Antagonist for the Treatment of Acute Episodic Migraine. | Download |
| Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery. | Download |
| Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide. | Download |
| Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer. | Download |
| BPI-3016, a novel long-acting hGLP-1 analogue for the treatment of Type 2 diabetes mellitus. | Download |
| Orientational Nanoconjugation with Gold Endows Marked Antimicrobial Potential and Drugability of Ultrashort Dipeptides. | Download |
| Human Amyloid-β40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo. | Download |
| Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes. | Download |
| Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord. | Download |
| N-Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein. | Download |
| Targeting the TLR2 Receptor With a Novel Thymopentin-Derived Peptide Modulates Immune Responses. | Download |
| Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses. | Download |
| A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity. | Download |
| A Hybrid Platform Based on a Bispecific Peptide-Antibody Complex for Targeted Cancer Therapy. | Download |
| Novel mono-PEGylated dimeric GLP-1 conjugate with enhanced receptor activation and prolonged anti-diabetes efficacies. | Download |
| Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice. | Download |
| Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 after single subcutaneous administration in healthy subjects. | Download |
| Rational design of dimeric lipidated Xenopus glucagon-like peptide 1 analogues as long-acting antihyperglycaemic agents. | Download |
| Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. | Download |
| Intranasal Delivery of a Methyllanthionine-Stabilized Galanin Receptor-2-Selective Agonist Reduces Acute Food Intake. | Download |
| DR7dA, a Novel Antioxidant Peptide Analog, Demonstrates Antifibrotic Activity in Pulmonary Fibrosis | Download |
| Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | Download |
| Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab-based therapeutics. | Download |
| Pharmacokinetics, pharmacodynamics, and tolerability of an aqueous formulation of rusfertide (PTG-300), a hepcidin mimetic, in healthy volunteers: A double-blind first-in-human study. | Download |
| A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile. | Download |
| Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog. | Download |
| Molecular Imaging and Preclinical Studies of Radiolabeled Long-Term RGD Peptides in U-87 MG Tumor-Bearing Mice. | Download |
| Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer's Disease. | Download |
| IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies. | Download |
| Linker engineering in anti-TAG-72 antibody fragments optimizes biophysical properties, serum half-life, and high-specificity tumor imaging. | Download |
| Pharmacokinetics and Exposure-Response of Vosoritide in Children with Achondroplasia. | Download |
| Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. | Download |
| Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity. | Download |
| Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia. | Download |
| Fusion Peptide Improves Stability and Bioactivity of Single Chain Antibody against Rabies Virus. | Download |
| Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability. | Download |
| Annexin A1 liquid pharmaceutical composition. | Download |
| GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study. | Download |
| GsMTx4-D provides protection to the D2.mdx mouse. | Download |
| Functional polymorphisms in rhesus macaque FCGRT and β2-m. | Download |
| Long-Acting C-Terminal Peptide-Modified hGH (MOD-4023): Results of a Safety and Dose-Finding Study in GHD Children. | Download |
| Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. | Download |
| A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects. | Download |
| A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects. | Download |
| A safety and pharmacokinetic dosing study of glucagon-like peptide 2 in infants with intestinal failure. | Download |
| New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice. | Download |
| Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate. | Download |
| Antibody-Assisted Delivery of a Peptide-Drug Conjugate for Targeted Cancer Therapy. | Download |
| Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects. | Download |
| A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects. | Download |
| Establishment of an indirect ELISA for detection of the novel antifibrotic peptide M10. | Download |
| A phase I clinical trial of dTCApFs, a derivative of a novel human hormone peptide, for the treatment of advanced/metastatic solid tumors. | Download |
| Phase 1 Safety, Pharmacokinetics, and Fluorescence Imaging Study of Tozuleristide (BLZ-100) in Adults With Newly Diagnosed or Recurrent Gliomas. | Download |
| A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life. | Download |
| Modifying the Lantibiotic Mutacin 1140 for Increased Yield, Activity, and Stability. | Download |
| Surface Immobilization of Anti-VEGF Peptide on SPIONs for Antiangiogenic and Targeted Delivery of Paclitaxel in Non-Small-Cell Lung Carcinoma. | Download |
| Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ( BRCA2) Mutation. | Download |
| Enfuvirtide-PEG conjugate: A potent HIV fusion inhibitor with improved pharmacokinetic properties. | Download |
| An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor. | Download |
| Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation. | Download |
| The Pharmacokinetics in Mice and Cell Uptake of Thymus Immunosuppressive Pentapeptide Using LC-MS/MS Analysis. | Download |
| Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues. | Download |
| Expression and bioactivity of recombinant human serum albumin and dTMP fusion proteins in CHO cells. | Download |
| Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery. | Download |
| A study of 2-component i, i + 3 peptide stapling using thioethers. | Download |
| Albumin binding Nanofitins, a new scaffold to extend half-life of biologics - a case study with exenatide peptide. | Download |
| Design and evaluation of novel natriuretic peptide derivatives with improved pharmacokinetic and pharmacodynamic properties. | Download |
| Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability. | Download |
| Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles. | Download |
| Anchor, Spacer, and Ligand-Modified Engineered Exosomes for Trackable Targeted Therapy. | Download |
| Optimizing CSP1 analogs for modulating quorum sensing in Streptococcus pneumoniae with bulky, hydrophobic nonproteogenic amino acid substitutions. | Download |
| Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased | Download |
| Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression. | Download |
| The antimicrobial peptide ZY4 combats multidrug-resistant | Download |
| Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial. | Download |
| The unique C-mannosylated hypertrehalosemic hormone of Carausius morosus: Identity, release, and biological activity. | Download |
| A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of a First-in-Human Engineered Cationic Peptide, PLG0206, Intravenously Administered in Healthy Subjects. | Download |
| A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides. | Download |
| C-terminal site-specific PEGylated Exendin-4 analog: A long-acting glucagon like Peptide-1 receptor agonist, on glycemic control and beta cell function in diabetic db/db mice. | Download |
| A Drug Carrier for Sustained Zero-Order Release of Peptide Therapeutics. | Download |
| UniCAR-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells. | Download |
| Biased agonists with less glucagon-like peptide-1 receptor-mediated endocytosis prolong hypoglycaemic effects. | Download |
| Hyaluronic acid-endostatin2-alft1 (HA-ES2-AF) nanoparticle-like conjugate for the target treatment of diseases. | Download |
| Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide. | Download |
| Site-Specific Lipidation of a Small-Sized Protein Binder Enhances the Antitumor Activity through Extended Blood Half-Life. | Download |
| PEGylated leuprolide with improved pharmacokinetic properties. | Download |
| Safety, biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 99m Tc-maraciclatide in healthy volunteers. | Download |
| LC-MS/MS assay for the determination of a novel D-peptide antagonist of CXCR4 in rat plasma and its application to a preclinical pharmacokinetic study. | Download |
| Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action. | Download |
| Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein. | Download |
| An approach for half-life extension and activity preservation of an anti-diabetic peptide drug based on genetic fusion with an albumin-binding aptide. | Download |
| Improvement of in vitro stability and pharmacokinetics of hIFN-α by fusing the carboxyl-terminal peptide of hCG β-subunit. | Download |
| Comparative Study of Chemical Stability of a PK20 Opioid-Neurotensin Hybrid Peptide and Its Analogue [Ile9] PK20-The Effect of Isomerism of a Single Amino Acid. | Download |
| Production of active Exendin-4 in Nicotiana benthamiana and its application in treatment of type-2 diabetics. | Download |
| Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model. | Download |
| Half-life extension of porcine interferon-α by fusion to the IgG-binding domain of streptococcal G protein. | Download |
| Determination of the Peptide AWRK6 in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and Its Application to Pharmacokinetics. | Download |
| Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment. | Download |
| The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs. | Download |
| Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions. | Download |
| Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis. | Download |
| Optimisation of a Microfluidic Method for the Delivery of a Small Peptide. | Download |
| A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein. | Download |
| Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study. | Download |
| In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans. | Download |
| Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents. | Download |
| EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer. | Download |
| Discovery of lixisenatide analogues as long-acting hypoglycemic agents using novel peptide half-life extension technology based on mycophenolic acid. | Download |
| Enhancing the circulating half-life and the antitumor effects of a tumor-selective cytotoxic peptide by exploiting endogenous serum albumin as a drug carrier. | Download |
| Increasing the bioactive space of peptide macrocycles by thioamide substitution. | Download |
| CPProtectides: Rapid uptake of well-folded β-hairpin peptides with enhanced resistance to intracellular degradation. | Download |
| Clinical Pharmacokinetics of Oral Semaglutide: Analyses of Data from Clinical Pharmacology Trials. | Download |
| Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein. | Download |
| Site-specific fatty chain-modified exenatide analogs with balanced glucoregulatory activity and prolonged in vivo activity. | Download |
| Population pharmacokinetics and exposure-response analyses of teduglutide in adult and pediatric patients with short bowel syndrome. | Download |
| Degradation of thymic humoral factor γ2 in human, rat and mouse blood: An experimental and theoretical study. | Download |
| Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors. | Download |
| Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells. | Download |
| Polyethylene Glycol 40-Modified Peptide with High Therapeutic Efficacy in Simian-Human Immunodeficiency Virus-Acutely Infected Rhesus Monkeys. | Download |
| Pharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus. | Download |
| Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update. | Download |
| In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone. | Download |
| Human Relaxin-2 Fusion Protein Treatment Prevents and Reverses Isoproterenol-Induced Hypertrophy and Fibrosis in Mouse Heart. | Download |
| Augmented antitumor immune responses of HER2-targeted pyroptotic induction by long-lasting recombinant immunopyroptotins. | Download |
| MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics, and Preliminary Imaging of | Download |
| Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review. | Download |
| Pharmacokinetics of Glepaglutide, A Long-Acting Glucagon-Like Peptide-2 Analogue: A Study in Healthy Subjects. | Download |
| The dual effects of a novel peptibody on angiogenesis inhibition and M2 macrophage polarization on sarcoma. | Download |
| Human cell-expressed tag-free rhMFG-E8 as an effective radiation mitigator. | Download |
| In vitro and in vivo characterization of an interleukin-15 antagonist peptide by metabolic stability, | Download |
| Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model. | Download |
| Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP. | Download |
| Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NT | Download |
| Sitagliptin Decreases Visceral Fat and Blood Glucose in Women With Polycystic Ovarian Syndrome. | Download |
| Purification and Activity Evaluation of a Novel Thrombopoietin Mimetic Peptide. | Download |
| Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable. | Download |
| In vivo characterisation of a therapeutically relevant self-assembling | Download |
| PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology. | Download |
| Long-Acting Human Interleukin 2 Bioconjugate Modified with Fatty Acids by Sortase A. | Download |
| Fluorescent peptide highlights micronodules in murine hepatocellular carcinoma models and humans in vitro. | Download |
| [(WR)8WKβA]-Doxorubicin Conjugate: A Delivery System to Overcome Multi-Drug Resistance against Doxorubicin. | Download |
| Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells. | Download |
| Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum. | Download |
| COMPOSITIONS AND METHODS RELATED TO TUMOR ACTIVATED ANTIBODIES TARGETING TROP2 AND EFFECTOR CELL ANTIGENS. | Download |
| Clearance kinetics of the VGF-derived neuropeptide TLQP-21. | Download |
| Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding. | Download |
| Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization. | Download |
| A once-monthly GLP-1 receptor agonist for treatment of diabetic cats. | Download |
| All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance. | Download |
| Development and biological activity of long-acting recombinant human interferon-α2b. | Download |
| Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide. | Download |
| Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema. | Download |
| Novel glucagon- and OXM-based peptides acting through glucagon and GLP-1 receptors with body weight reduction and anti-diabetic properties. | Download |
| An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides. | Download |
| Cellular studies of the two main isoforms of human d-aspartate oxidase. | Download |
| An Effective and Safe Enkephalin Analog for Antinociception. | Download |
| Biochemical and biophysical combined study of bicarinalin, an ant venom antimicrobial peptide. | Download |
| Assessment of the Pharmacokinetics, Disposition, and Duration of Action of the Tumour-Targeting Peptide CEND-1. | Download |
| Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB. | Download |
| Albumin-binding domain extends half-life of glucagon-like peptide-1. | Download |
| Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(ε-caprolactone) micelles. | Download |
| A Novel Peptide Ameliorates LPS-Induced Intestinal Inflammation and Mucosal Barrier Damage via Its Antioxidant and Antiendotoxin Effects. | Download |
| Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment. | Download |
| TNF SUPERFAMILY COLLECTIN FUSION PROTEINS. | Download |
| Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation. | Download |
| Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain. | Download |
| The generation and biological activity of a long-lasting recombinant human interferon-λ1. | Download |
| Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via | Download |
| Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds. | Download |
| An Investigation into the Gastrointestinal Stability of Exenatide in the Presence of Pure Enzymes, Everted Intestinal Rings and Intestinal Homogenates. | Download |
| Decoding the human serum interactome of snake-derived antimicrobial peptide Ctn[15-34]: Toward an explanation for unusually long half-life. | Download |
| Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene. | Download |
| DR10601, a novel recombinant long-acting dual glucagon-like peptide-1 and glucagon receptor agonist for the treatment of obesity and type 2 diabetes mellitus. | Download |
| Aspergillus nidulans thermostable arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity. | Download |
| APJ as Promising Therapeutic Target of Peptide Analogues in Myocardial Infarction- and Hypertension-Induced Heart Failure. | Download |
| Transnasal Delivery of the Peptide Agonist Specific to Neuromedin-U Receptor 2 to the Brain for the Treatment of Obesity. | Download |
| Improved pharmacokinetics and bone tissue accumulation of Angiotensin-(1-7) peptide through bisphosphonate conjugation. | Download |
| C-terminal tails mimicking bioactive intermediates cause different plasma degradation patterns and kinetics in neuropeptides γ-MSH, α-MSH, and neurotensin. | Download |
| Design of novel lipidated peptidomimetic conjugates for targeting EGFR heterodimerization in HER2 + cancer. | Download |
| Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice. | Download |
| A novel peptide shows excellent anti-HIV-1 potency as a gp41 fusion inhibitor. | Download |
| Preparation and evaluation of a 68Ga-labeled RGD-containing octapeptide for noninvasive imaging of angiogenesis: biodistribution in non-human primate. | Download |
| A novel fibrinolytic serine metalloprotease from the marine Serratia marcescens subsp. sakuensis: Purification and characterization. | Download |
| A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment. | Download |
| The Influence of Dimerization on the Pharmacokinetics and Activity of an Antibacterial Enzyme Lysostaphin. | Download |
| ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. | Download |
| Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases. | Download |
| A Randomized Trial Investigating the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Semaglutide Once-Weekly in Healthy Male Japanese and Caucasian Subjects. | Download |
| Molecular and Biological Characterization of a Prepared Recombinant Human Interferon Alpha 2b Isoform. | Download |
| Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs. | Download |
| Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction. | Download |
| Pharmacological Evaluation of a Pegylated Urocortin-1 Peptide in Experimental Autoimmune Disease Models. | Download |
| Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens. | Download |
| 68Ga-NOTA-Functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry, and First-in-Human PET/CT Imaging of Infections. | Download |
| Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV-1 Fusion Inhibitor Peptide. | Download |
| Targeted thrombolysis by using c-RGD-modified N,N,N-Trimethyl Chitosan nanoparticles loaded with lumbrokinase. | Download |
| Influence of route of administration and lipidation of apolipoprotein A-I peptide on pharmacokinetics and cholesterol mobilization. | Download |
| Population pharmacokinetics of the GIP/GLP receptor agonist tirzepatide. | Download |
| Quantitative analyses for effects of neddylation on CRL2 VHL substrate ubiquitination and degradation. | Download |
| Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases. | Download |
| Palmitic Acid-Conjugated Radiopharmaceutical for Integrin α | Download |
| N-Methylation of Amino Acids in Gelatinase Biosynthesis-Activating Pheromone Identifies Key Site for Stability Enhancement with Retention of the Enterococcus faecalis fsr Quorum Sensing Circuit Response. | Download |
| Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein. | Download |
| Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. | Download |
| PEGylation improves the therapeutic potential of dimerized translationally controlled tumor protein blocking peptide in ovalbumin-induced mouse model of airway inflammation. | Download |
| Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity. | Download |
| Long-acting antibody ligand mimetics for HER4-selective agonism. | Download |
| GHRELIN AGONISTS WITH IMPROVED POTENCY. | Download |
| Alanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation. | Download |
| A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides. | Download |
| Molecular Characterization of a Copper Metallothionein Gene From a Ciliate Tetrahymena farahensis. | Download |
| Dual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii. | Download |
| Design, in silico and pharmacological evaluation of a peptide inhibitor of BACE-1. | Download |
| GLP-1 PRODRUGS AND USES HEREOF. | Download |
| Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection | Download |
| An Automated and Qualified Platform Method for Site-Specific Succinimide and Deamidation Quantitation Using Low-pH Peptide Mapping. | Download |
| ATN-161 Peptide Functionalized Reversibly Cross-Linked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice. | Download |
| Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system. | Download |
| Pharmacokinetics, Safety, and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment. | Download |
| Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. | Download |
| A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS. | Download |
| Improving the Robustness of Engineered Bacteria to Nutrient Stress Using Programmed Proteolysis. | Download |
| Studies of Thioamide Effects on Serine Protease Activity Enable Two-Site Stabilization of Cancer Imaging Peptides. | Download |
| A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity. | Download |
| Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics. | Download |
| The molecular pharmacology of glucagon agonists in diabetes and obesity. | Download |
| Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome. | Download |
| Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold. | Download |
| Preclinical Validation of Tumor-Penetrating and Interfering Peptides against Chronic Lymphocytic Leukemia. | Download |
| Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice. | Download |
| Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization. | Download |
| N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties. | Download |
| Glycosaminoglycan Conjugation for Improving the Duration of Therapeutic Action of Glucagon-Like Peptide-1. | Download |
| Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. | Download |
| Trimeric PEG-Conjugated Exendin-4 for the Treatment of Sepsis. | Download |
| Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs. | Download |
| NOVEL BINDING PROTEINS FOR PCSK9. | Download |
| Novel peptidic dual GLP-1/glucagon receptor agonist alleviates diabetes and diabetic complications in combination with low-intensity ultrasound. | Download |
| In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA. | Download |
| Preparation, Characterization and Pharmacokinetic Study of N-Terminal PEGylated D-Form Antimicrobial Peptide OM19r-8. | Download |
| Single chain antibody fragments with pH dependent binding to FcRn enabled prolonged circulation of therapeutic peptide in vivo. | Download |
| Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. | Download |
| Development of potent and proteolytically stable human neuromedin U receptor agonists. | Download |
| α/Sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged In Vivo Activity. | Download |
| d-amino acid modification protects N-Acetyl-seryl-aspartyl-lysyl-proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis. | Download |
| Polymeric Nanotubes as Drug Delivery Vectors─Comparison of Covalently and Supramolecularly Assembled Constructs. | Download |
| Designed ferritin nanocages displaying trimeric TRAIL and tumor-targeting peptides confer superior anti-tumor efficacy. | Download |
| Molecular Imaging of Mesothelin-Expressing Ovarian Cancer with a Human and Mouse Cross-Reactive Nanobody. | Download |
| An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications. | Download |
| Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia. | Download |
| Kinetics of neuropeptide Y, catecholamines, and physiological responses during moderate and heavy intensity exercises. | Download |
| Design, screening and biological evaluation of novel fatty acid chain-modified oxyntomodulin-based derivatives with prolonged glucose-lowering ability and potent anti-obesity effects. | Download |
| Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice. | Download |
| Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models. | Download |
| Impact of C- and N-terminal protection on the stability, metal chelation and antimicrobial properties of calcitermin. | Download |
| Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy. | Download |
| Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality. | Download |
| Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing. | Download |
| FCRN/HSA BINDING MOLECULES AND METHODS OF USE. | Download |
| A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study. | Download |
| Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis. | Download |
| A Dual Alkylated Peptide-ligand Enhances Affinity to Human Serum Albumin. | Download |
| Bifunctional GM-CSF-derived peptides as tools for O-glycoengineering and protein tagging. | Download |
| Conjugates for use in peptide therapeutics: A systematic review and meta-analysis. | Download |
| A minimally-invasive serial cerebrospinal fluid sampling model in conscious Göttingen minipigs. | Download |
| A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life. | Download |
| Evaluation of Physicochemical Properties, Pharmacokinetics, Biodistribution, Toxicity, and Contrast-Enhanced Cancer MRI of a Cancer-Targeting Contrast Agent, MT218. | Download |
| Exendin 4-Hapten Conjugate Capable of Binding with Endogenous Antibodies for Peptide Half-life Extension and Exerting Long-Acting Hypoglycemic Activity. | Download |
| Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents. | Download |
| Therapeutic effects of different doses of polyethylene glycosylated porcine glucagon-like peptide-2 on ulcerative colitis in male rats. | Download |
| PGLP-1, a novel long-acting dual-function GLP-1 analog, ameliorates streptozotocin-induced hyperglycemia and inhibits body weight loss. | Download |
| RECOMBINANT FUSION PROTEINS COMPRISING INTERLEUKIN-18-BINDING PROTEIN AND ANTIGEN BINDING FRAGMENT TO SERUM ALBUMIN, AND COMPOSITIONS AND USES THEREOF | Download |
| Synthetic CXCR4 Antagonistic Peptide Assembling with Nanoscaled Micelles Combat Acute Myeloid Leukemia. | Download |
| A kidney-selective biopolymer for targeted drug delivery. | Download |
| Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding. | Download |
| PROTEIN Z VARIANTS BINDING THYMIC STROMAL LYMPHOPOIETIN AND THEIR MEDICAL USE. | Download |
| A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis. | Download |
| First-in-Humans Study of the SSTR Antagonist 177Lu-DOTA-LM3 for Peptide Receptor Radionuclide Therapy in Patients with Metastatic Neuroendocrine Neoplasms: Dosimetry, Safety, and Efficacy. | Download |
| Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin. | Download |
| Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model. | Download |
| Phenylbutazone, a New Long-Acting Agent that can Improve the Peptide Pharmacokinetic Based on Serum Albumin as a Drug Carrier. | Download |
| Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications. | Download |
| Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers. | Download |
| Systemic administration of enzyme-responsive growth factor nanocapsules for promoting bone repair. | Download |
| Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system. | Download |
| Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Agonist, GLP-1-IgG2σ-Fc. | Download |
| NOVEL INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF. | Download |
| Triazolopeptides Inhibiting the Interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165. | Download |
| Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology. | Download |
| Self-assembled nanoparticles comprising aptide-SN38 conjugates for use in targeted cancer therapy. | Download |
| A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs. | Download |
| Linking (Pyr) 1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents. | Download |
| An Albumin-Binding Domain Peptide Confers Enhanced Immunoprotection Against Viral Myocarditis by CVB3 VP1 Vaccine. | Download |
| Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage. | Download |
| Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control. | Download |
| Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway. | Download |
| Ferritin nanocage with intrinsically disordered proteins and affibody: A platform for tumor targeting with extended pharmacokinetics. | Download |
| Research Advances in Fusion Protein-Based Drugs for Diabetes Treatment. | Download |
| Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects with Renal Impairment. | Download |
| Safety, tolerability, pharmacokinetics, and pharmacodynamics of TG103 injection in participants who are overweight or obese: a randomized, double-blind, placebo-controlled, multiple-dose phase 1b study. | Download |
| Optimized functional and structural design of dual-target LMRAP, a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment. | Download |
| Rapid Prediction of Deamidation Rates of Proteins to Assess Their Long-Term Stability Using Hydrogen Exchange-Mass Spectrometry. | Download |
| Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic. | Download |
| Acetylation and Amination Protect Angiotensin 1-7 from Physiological Hydrolyzation and Therefore Increases Its Antitumor Effects on Lung Cancer. | Download |
| Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy. | Download |
| In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. | Download |
| Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice. | Download |
| A Novel Homodimer Peptide-Drug Conjugate Improves the Efficacy of HER2-Positive Breast Cancer Therapy. | Download |
| Comparison of the Tissue Distribution of a Long-Circulating Glucagon-like Peptide-1 Agonist Determined by Positron Emission Tomography and Quantitative Whole-Body Autoradiography. | Download |
| Long-Acting Release Microspheres Containing Novel GLP-1 Analog as an Antidiabetic System. | Download |
| In Vitro Properties and Pharmacokinetics of Temporarily PEGylated Onc72 Prodrugs. | Download |
| Tuning the Cross-Linking Density and Cross-Linker in Core Cross-Linked Polymeric Micelles and Its Effects on the Particle Stability in Human Blood Plasma and Mice. | Download |
| CONJUGATES COMPRISING AN GLP-1/GLUCAGON DUAL AGONIST, A LINKER AND HYALURONIC ACID. | Download |
| Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4. | Download |
| The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans. | Download |
| Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice. | Download |
| De Novo Design of an Androgen Receptor DNA Binding Domain-Targeted peptide PROTAC for Prostate Cancer Therapy. | Download |
| Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life. | Download |
| Rhesus θ-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. | Download |
| Construction, Purification, and Characterization of a Homodimeric Granulocyte Colony-Stimulating Factor. | Download |
| Exploring a novel long-acting glucagon-like peptide-1 receptor agonist built on the albumin-binding domain and XTEN scaffolds. | Download |
| Long-Acting Release Formulation of Exendin-4 Based on Biomimetic Mineralization for Type 2 Diabetes Therapy. | Download |
| DSPE-PEG Modification of α-Conotoxin TxID. | Download |
| SPION-Decorated Exosome Delivered BAY55-9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response. | Download |
| Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin. | Download |
| Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals. | Download |
| Characterization of therapeutic protein AvidinOX by an integrated analytical approach. | Download |
| Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mice. | Download |
| Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. | Download |
| The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis. | Download |
| Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides. | Download |
| Genetically Encoding a Lipidated Amino Acid for Extension of Protein Half-Life in vivo. | Download |
| A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS. | Download |
| ANNEXIN AI LIQUID PHARMACEUTICAL COMPOSITION. | Download |
| Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Trial of Synthetic Preimplantation Factor in Autoimmune Hepatitis. | Download |
| The discovery of potent and stable short peptide FGFR1 antagonist for cancer therapy. | Download |
| A DPP-IV-resistant glucagon-like peptide-2 dimer with enhanced activity against radiation-induced intestinal injury. | Download |
| Clinical Pharmacokinetics of Semaglutide: A Systematic Review. | Download |
| Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation. | Download |
| Effect of Loading Method on a Peptide Substrate Reporter in Intact Cells. | Download |
| Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential. | Download |
| Pharmacokinetic study based on a matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight imaging mass microscope combined with a novel relative exposure approach: A case of octreotide in mouse target tissues. | Download |
| Assessment of individual and standardized glucagon kinetics in healthy humans. | Download |
| Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment. | Download |
| Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure. | Download |
| Binding and biologic characterization of recombinant human serum albumin-eTGFBR2 fusion protein expressed in CHO cells. | Download |
| High-level expression and purification of a molluskan endoglucanase from Ampullaria crossean in Pichia pastoris. | Download |
| Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. | Download |
| Mono-PEGylates of exenatide in branched and dimeric structures can improve in vivo stability and hypoglycemic bioactivity. | Download |
| Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity. | Download |
| Fc-Elabela fusion protein attenuates lipopolysaccharide-induced kidney injury in mice. | Download |
| Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer. | Download |
| Lymphatic uptake of the lipidated and non-lipidated GLP-1 agonists liraglutide and exenatide is similar in rats. | Download |
| Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery. | Download |
| Near-Infrared Imaging of Colonic Adenomas In Vivo Using Orthotopic Human Organoids for Early Cancer Detection. | Download |
| In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy. | Download |
| In-vivo half-life and hypoglycemic bioactivity of a fusion protein of exenatide and elastin-based polypeptide from recombinant Saccharomyces cerevisiae. | Download |
| Preventive Effects of Thermosensitive Biopolymer-Conjugated C-Peptide against High Glucose-Induced Endothelial Cell Dysfunction. | Download |
| Comparative study of the neuroprotective and nootropic activities of the carboxylate and amide forms of the HLDF-6 peptide in animal models of Alzheimer's disease. | Download |
| LC-MS/MS assay for the determination of tat-K13, a novel interfering peptide for the treatment of ischemic stroke, in human plasma and its application to a pharmacokinetics study. | Download |
| Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice. | Download |
| A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist. | Download |
| Novel mono-lipidated dimeric glucagon-like peptide-1 receptor agonist with improved long-acting and hypoglycemic activity. | Download |
| Purification and characterization of a long-acting ciliary neurotrophic factor via genetically fused with an albumin-binding domain. | Download |
| Facile and Efficient Chemoenzymatic Semisynthesis of Fc-Fusion Compounds for Half-Life Extension of Pharmaceutical Components. | Download |
| A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function. | Download |
| Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor. | Download |
| Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy. | Download |
| In vitro characterization of MOD-5014, a novel long-acting carboxy-terminal peptide (CTP)-modified activated FVII. | Download |
| Engineering an Automaturing Transglutaminase with Enhanced Thermostability by Genetic Code Expansion with Two Codon Reassignments. | Download |
| Enhancing the Accumulation of Polymer Micelles by Selectively Dilating Tumor Blood Vessels with NO for Highly Effective Cancer Treatment. | Download |
| Intratumoral distribution of YSNSG cyclopeptide in a mouse melanoma model using microdialysis. | Download |
| MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study. | Download |
| HM15912, a Novel Long-Acting Glucagon-Like Peptide-2 Analog, Improves Intestinal Growth and Absorption Capacity in a Male Rat Model of Short Bowel Syndrome. | Download |
| Conjugation of sulpiride with a cell penetrating peptide to augment the antidepressant efficacy and reduce serum prolactin levels. | Download |
| Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and Diabetes. | Download |
| DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels. | Download |
| High-Affinity Antibody Detection with a Bivalent Circularized Peptide Containing Antibody-Binding Domains. | Download |
| PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE. | Download |
| Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy. | Download |
| Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy. | Download |
| CAR, a Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil. | Download |
| Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. | Download |
| Pharmacokinetics of gemcitabine and its amino acid ester prodrug following intravenous and oral administrations in mice. | Download |
| A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies. | Download |
| An enhanced broad-spectrum peptide inhibits Omicron variants in vivo. | Download |
| PROPHYLACTIC USES OF THETA DEFENSINS. | Download |
| Clinical Pharmacokinetics of Dulaglutide in Patients with Type 2 Diabetes: Analyses of Data from Clinical Trials. | Download |
| N-Terminal Modification of the Tetrapeptide Arg-Leu-Tyr-Glu, a Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Antagonist, Improves Antitumor Activity by Increasing its Stability against Serum Peptidases. | Download |
| AAZTA-Like Ligands Bearing Phenolate Arms as Efficient Chelators for 68 Ga Labelling in vitro and in vivo. | Download |
| First-in-human safety, tolerability, and pharmacokinetics of SY-007, a prolonged action neuroprotective drug for ischemic stroke, in healthy Chinese subjects. | Download |
| RGD-decorated redox-responsive d-α-tocopherol polyethylene glycol succinate-poly(lactide) nanoparticles for targeted drug delivery. | Download |
| Diagnosis of LVAD Thrombus using a High-Avidity Fibrin-Specific 99mTc Probe. | Download |
| MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY | Download |
| The Exonization and Functionalization of an Alu-J Element in the Protein Coding Region of Glycoprotein Hormone Alpha Gene Represent a Novel Mechanism to the Evolution of Hemochorial Placentation in Primates. | Download |
| A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction. | Download |
| Prolonged half-life of small-sized therapeutic protein using serum albumin-specific protein binder. | Download |
| Delivery of a TNF-α-derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis. | Download |
| Novel stable analogues of the neurotensin C-terminal hexapeptide containing unnatural amino acids. | Download |
| Tuning protein half-life in mouse using sequence defined biopolymers functionalized with lipids. | Download |
| 18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of neuroendocrine tumors (NETs). | Download |
| Novel fatty acid chain modified GLP-1 derivatives with prolonged in vivo glucose-lowering ability and balanced glucoregulatory activity. | Download |
| Direct delivery of plasmin using clot-anchoring thrombin-responsive nanoparticles for targeted fibrinolytic therapy. | Download |
| Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's disease. | Download |
| Human FcRn Tissue Expression Profile and Half-Life in PBMCs. | Download |
| INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF | Download |
| A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy. | Download |
| Characterization of a Multimodular Endo-β-1,4-Glucanase (Cel9K) from Paenibacillus sp. X4 with a Potential Additive for Saccharification. | Download |
| Gemcitabine and Chlorotoxin Conjugated Iron Oxide Nanoparticles for Glioblastoma Therapy. | Download |
| Effect of Synthetic High Density Lipoproteins Modification with Polyethylene Glycol on Pharmacokinetics and Pharmacodynamics. | Download |
| Pharmacokinetic Study of SKL-18287, a Novel Long-Acting Glucagon-Like Peptide-1 Receptor Agonist, in Rats, Monkeys and Mini-Pigs. | Download |
| Fc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in mice. | Download |
| Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling. | Download |
| N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. | Download |
| Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. | Download |
| Effects of Hepatic Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide. | Download |
| Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates. | Download |
| GLP-1 analogue CJC-1131 prevents amyloid β protein-induced impirments of spatial memory and synaptic plasticity in rats. | Download |
| Identification of the effect of N-glycan modification and its sialylation on proteolytic stability and glucose-stabilizing activity of glucagon-like peptide 1 by site-directed enzymatic glycosylation. | Download |
| Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects. | Download |
| Adrenomedullin 2.0: Adjusting Key Levers for Metabolic Stability. | Download |
| Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery. | Download |
| Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches. | Download |
| Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. | Download |
| BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors. | Download |
| High-density lipoprotein-mimicking nanodiscs carrying peptide for enhanced therapeutic angiogenesis in diabetic hindlimb ischemia. | Download |
| Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1. | Download |
| Real-time near-infrared fluorescence imaging using cRGD-ZW800-1 for intraoperative visualization of multiple cancer types. | Download |
| Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives. | Download |
| Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor. | Download |
| Structure-Activity Relationships and Characterization of Highly Selective, Long-Acting, Peptide-Based Cholecystokinin 1 Receptor Agonists. | Download |
| Development of Long-Acting Human Adrenomedullin Fc-Fusion Proteins. | Download |
| Effect of C-terminus Conjugation via Different Conjugation Chemistries on In Vivo Activity of Albumin-Conjugated Recombinant GLP-1. | Download |
| An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug. | Download |
| A long-acting C-natriuretic peptide for achondroplasia. | Download |
| Novel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight. | Download |
| [MeArg1, NLe10]-apelin-12: Optimization of solid-phase synthesis and evaluation of biological properties in vitro and in vivo. | Download |
| Metabolism of peptide YY 3-36 in Göttingen mini-pig and rhesus monkey. | Download |
| DR10627, a Novel Dual Glucagon‑like Peptide‑1 and Gastric Inhibitory Polypeptide Receptor Agonist for the Treatment of Obesity and Type 2 Diabetes Mellitus. | Download |
| Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers. | Download |
| Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity. | Download |
| Phospholipid Component Defines Pharmacokinetic and Pharmacodynamic Properties of Synthetic High-Density Lipoproteins. | Download |
| In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs. | Download |
| DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer. | Download |
| New peptides as potent and selective GIP Receptor agonists. | Download |