The Total number of records shown on this page is 12. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_5544	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft subcutaneous for U86 (3.0E+6)	5.0E+6 pfu	NA	Tumor size was significantly smaller in treated mice compared to control	Intravenously	NA	NA	NA	US6770274
OV_5545	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft subrenal for U86 (3.0E+6)	5.0E+6 pfu	NA	Tumor size was significantly smaller in treated mice compared to control	Intravenously	NA	NA	NA	US6770274
OV_5546	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft intracerebral for U86 (1.6E+5)	1.0E+3 pfu	NA	Three of seven mice survived after 7 week	Intravenously	NA	NA	NA	US6770274
OV_5547	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft intracerebral for U86 (1.6E+5)	1.0E+5 pfu	NA	Four of seven mice survived after 7 week	Intravenously	NA	NA	NA	US6770274
OV_5548	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft intracerebral for U86 (1.6E+5)	1.0E+3 pfu	NA	All mice was dead after week 14	Intravenously	NA	NA	NA	US6770274
OV_5549	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human malignant cell line	U87	NA	NA	NA	NA	NA	Fisher male mice xenograft intracerebral for U86 (1.6E+5)	1.0E+5 pfu	NA	Two of seven mice survived after 14 week	Intravenously	NA	NA	NA	US6770274
OV_5674	Herpes simplex virus	HSV-G47-delta	DNA	Herpesviridae	Deletion mutatnt for Gamma 34.5, ICP6 and ICP47 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	A/J mice isograft for Neuro2a cell line (5.0E+6)	1.0E+6 pfu	NA	Reduction in tumor volume to 2500mm after 17 days	Intratumoral	NA	Induction of IL-12 and IFn-gamma production	NA	US7655459
OV_5675	Herpes simplex virus	HSV-G47-delta	DNA	Herpesviridae	Deletion mutatnt for Gamma 34.5, ICP6 and ICP47 gene	No	Virus in combination with IL-18	No	NA	NA	NA	NA	NA	NA	NA	NA	A/J mice isograft for Neuro2a cell line (5.0E+6)	1.0E+6 pfu	NA	Reduction in tumor volume below 500mm after 17 days	Intratumoral	NA	Induction of IL-12 and IFn-gamma production	NA	US7655459
OV_5676	Herpes simplex virus	HSV-G47-delta	DNA	Herpesviridae	Deletion mutatnt for Gamma 34.5, ICP6 and ICP47 gene	No	Virus in combination with IL-18 (1microgram/day)	No	NA	NA	NA	NA	NA	NA	NA	NA	A/J mice isograft for Neuro2a cell line (5.0E+6)	2.0E+6 pfu	NA	Reduction in tumor volume to 700mm after 15 days compared to control 2200mm	Intratumoral	NA	Induction of IL-12 and IFn-gamma production	NA	US7655459
OV_5677	Herpes simplex virus	HSV-R8306	DNA	Herpesviridae	Deletion mutant for Gamma 34.5 gene and addition of IL-4 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	C57BL/6 mice xenograft for GL-261 (1.0E+5)	1.0E+6 pfu	NA	Increase in survival of mice up to 28 day	Intratumoral	NA	NA	NA	US7744899
OV_5678	Herpes simplex virus	HSV-R8306	DNA	Herpesviridae	Deletion mutant for Gamma 34.5 gene and addition of IL-10 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	C57BL/6 mice xenograft for GL-261 (1.0E+5)	1.0E+6 pfu	NA	Increase in survival of mice up to 26 day	Intratumoral	NA	NA	NA	US7744899
OV_5882	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5 gene	Yes	No	Virus expressing vasculostatin peptide	ATCC	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for U87DeltaEGFR	1.0E+5 pfu	NA	Survival time increased	Intratumoral	NA	NA	NA	US8450106