Detailed description page of Selected OV_ID


OV_5675 details
Primary information
OV_IDOV_5675
Virus Name Herpes simplex virus
StrainHSV-G47-delta
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutatnt for Gamma 34.5, ICP6 and ICP47 gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with IL-18
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismA/J mice isograft for Neuro2a cell line (5 ×10⁶)
In-vivo virus concentration1 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 500mm after 17 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectInduction of IL-12 and IFn-gamma production
Clinical trialNA
PMIDUS7655459